Objective:To explore the application effect of patient mutual assistance model guided by the hierarchy of needs theory in patients with acute myocardial infarction.Methods:Using the convenient sampling method, 40 patients with acute myocardial infarction in the Fourth People's Hospital of Haikou from September 2018 to October 2019 were selected as the control group and 40 patients with acute myocardial infarction from November 2019 to January 2021 were selected as the intervention group. The control group implemented the conventional nursing model, and the intervention group implemented the patient mutual assistance model guided by the hierarchy of needs theory on this basis. Perceived Stress Scale (PSS) , SDS and Herth Hope Scale (HHI) were used to evaluate the effect of intervention.Results:After the intervention, the total scores of PSS of patients in the two groups were lower than those before the intervention, and the difference was statistically significant ( P<0.01) . And the total PSS score of the intervention group was lower than that of the control group, and the difference was statistically significant ( P<0.01) . After the intervention, the total SDS score of patients of the two groups was lower than that before the intervention, and the difference was statistically significant ( P<0.01) . And the total SDS score of the intervention group was lower than that of the control group, and the difference was statistically significant ( P<0.01) . After intervention, the scores of HHI dimensions and total scores in two groups were higher than before intervention, and the differences were statistically significant ( P<0.01) . The scores of HHI dimensions and the total score of the intervention group were higher than those in the control group, and the differences were statistically significant ( P<0.01) . Conclusions:The patient mutual assistance model guided by the hierarchy of needs theory can effectively reduce the self-perceived pressure of patients with acute myocardial infarction after PCI, improve their depression and increase the level of hope.