Tribbles homolog 3(TRIB3,also named TRB3,NIPK,and SKIP3)belongs to the tribbles family of pseudokinases,that were first identified in Drosophila to regulate cell division and migration.TRIB3 expression is upregulated by endoplasmic reticulum stress,hypoxia,and nutrient starvation.Previous studies showed that TRIB3 expression was closely related to the progression of type 2 diabetes mellitus,and that TRIB3 mediated apoptosis in islet beta cells,as well as insulin resistance.Recent studies suggested that TRIB3 is a potential oncogene,as evidenced by its elevated expression in colorectal cancer,breast cancer,liver cancer and other cancer tissues.

Apoptosis is the autonomous death of cells,which is controlled by the genes and to maintain the homeostasis of the body.Apoptosis is the important mechanism in the cell's growth and development.Recent studies have found that apoptosis can affect the neighboring cells physiological process in microenvironment through directly contact or release a series of regulatory factor,which plays an important roles in the construction of tumor microenvironment.Therefore,understanding the roles of apoptosis in the normal and tumor microenvironment has great significance for further study the pathogenesis,prevention and treatment of tumor.