Tribbles homolog 3(TRIB3,also named TRB3,NIPK,and SKIP3)belongs to the tribbles family of pseudokinases,that were first identified in Drosophila to regulate cell division and migration.TRIB3 expression is upregulated by endoplasmic reticulum stress,hypoxia,and nutrient starvation.Previous studies showed that TRIB3 expression was closely related to the progression of type 2 diabetes mellitus,and that TRIB3 mediated apoptosis in islet beta cells,as well as insulin resistance.Recent studies suggested that TRIB3 is a potential oncogene,as evidenced by its elevated expression in colorectal cancer,breast cancer,liver cancer and other cancer tissues.

Apoptosis is the autonomous death of cells,which is controlled by the genes and to maintain the homeostasis of the body.Apoptosis is the important mechanism in the cell's growth and development.Recent studies have found that apoptosis can affect the neighboring cells physiological process in microenvironment through directly contact or release a series of regulatory factor,which plays an important roles in the construction of tumor microenvironment.Therefore,understanding the roles of apoptosis in the normal and tumor microenvironment has great significance for further study the pathogenesis,prevention and treatment of tumor.

Objective To explore the effect of intermittent fasting combined with diversified man-agement mode on weight loss of overweight and obese people.Methods A total of 120 overweight and obese patients were selected as research objects,and randomly divided into control group(n=60)and experimental group(n=60).The control group was given intermittent fasting,and the experimental group was given diversified management mode on the basis of the control group.Waist circumference,body mass,body mass index(BMI),waist-to-hip ratio and blood lipid level were compared between the two groups;the scores of hunger,satiety,satisfaction and the incidence of adverse reactions were compared between the two groups.Results After intervention,waist circumference,body mass,BMI,waist-to-hip ratio,total cholesterol(TC),triglyceride(TG)and low-density lipoprotein choles-terol(LDL-C)in the experimental group were significantly lower,and high-density lipoprotein choles-terol(HDL-C)was significantly higher than that in the control group(P＜0.05).After intervention,the hunger score of the experimental group was significantly lower,and the satiety score and satisfac-tion score were significantly higher than those of the control group(P＜0.05).The total incidence of adverse reactions in the experimental group was 6.67％,which was significantly lower than 20.00％in the control group(P＜0.05).Conclusion The application of intermittent fasting combined with diversified management mode in overweight and obese people is better,which can improve the relevant clinical indicators and blood lipid levels,and has high safety.

Objective To explore the effect of intermittent fasting combined with diversified man-agement mode on weight loss of overweight and obese people.Methods A total of 120 overweight and obese patients were selected as research objects,and randomly divided into control group(n=60)and experimental group(n=60).The control group was given intermittent fasting,and the experimental group was given diversified management mode on the basis of the control group.Waist circumference,body mass,body mass index(BMI),waist-to-hip ratio and blood lipid level were compared between the two groups;the scores of hunger,satiety,satisfaction and the incidence of adverse reactions were compared between the two groups.Results After intervention,waist circumference,body mass,BMI,waist-to-hip ratio,total cholesterol(TC),triglyceride(TG)and low-density lipoprotein choles-terol(LDL-C)in the experimental group were significantly lower,and high-density lipoprotein choles-terol(HDL-C)was significantly higher than that in the control group(P＜0.05).After intervention,the hunger score of the experimental group was significantly lower,and the satiety score and satisfac-tion score were significantly higher than those of the control group(P＜0.05).The total incidence of adverse reactions in the experimental group was 6.67％,which was significantly lower than 20.00％in the control group(P＜0.05).Conclusion The application of intermittent fasting combined with diversified management mode in overweight and obese people is better,which can improve the relevant clinical indicators and blood lipid levels,and has high safety.