1.Relationship between thyroid nodule combined with Hashimoto's thyroiditis and risk of thyroid cancer
Hua DONG ; Zuncheng ZHANG ; Yongtao GUO ; Shaoshi YANG ; Ping DONG
Chinese Journal of Endocrine Surgery 2018;12(3):244-246
Objective To evaluate the relationship between thyroid nodules combined with Hashimoto's thyroiditis(HT) and the risk of thyroid cancer.Methods This retrospective study included 1212 patients undergoing thyroidectomy in the Second Hospital of Tianjin Medical University from Jan.2010 to Jul.2017.The incidence of thyroid cancer in those thyroid nodules with and without HT based on the postoperative pathological results was compared.Results Among 843 patients of thyroid benign nodules,15.3% cases were complicated with HT.Of all the patients with malignant tumors,365 cases were PTC,accounting for 96.5% of all malignant tumors,and among whom,10.8% were complicated with HT.Of the 169 cases of thyroid nodules combined with HT,23.7% patients had PTC.For patients with thyroid nodules without HT,30.3% had PTC.The difference had no statistical significance (x2=3.08,P>0.05).Conclusion Thyroid nodules complicated with HT doesn't increase the incidence of thyroid cancer.
2.Research advances in pathophysiology, diagnosis and therapy of trauma-induced coagulopathy
Zheyuan SHEN ; Shuwei TIAN ; Yu KONG ; Shaoshi GUO ; Yingying DENG ; Aqin PENG
Chinese Journal of Trauma 2018;34(4):377-384
Objective Trauma-induced coagulopathy (TIC)is an acute coagulopathy in which coagulation,fibrinolysis,and anticoagulant pathways are activated after trauma due to massive hemorrhage and tissue damage.TIC is caused by hypothermia,acidosis,blood dilution,hyperfusion,tissue injury,etc.To diagnose TIC,we mainly rely on traditional coagulation function analysis and thrombelastogram (TEG).At present,the key to treat TIC is quick hemostasis.The basic treatment procedure includes transfusion of packed red blood cells and fresh frozen plasma by appropriate proportion,and timely infusion of platelets and coagulant material so as to stabilize blood pressure and reconstruct the blood coagulation mechanism.In this paper,we reviewed recent advances in the pathophysiological and treatment of TIC in order to provide references for further research in related fields.