1.Application and potential value of endogenous lipid mediators in liver failure
Gengjie YAN ; Yong LIN ; Huiji SU ; Hanxiao CHEN ; Shaoqun BAN ; Ailing WEI ; Dewen MAO ; Fuli LONG
Journal of Clinical Hepatology 2023;39(1):211-217
Liver failure is a common end-stage liver disease syndrome in clinical practice characterized by massive necrosis of hepatocytes leading to rapid liver failure, and it is currently believed that excessive inflammation and immune response are the core mechanisms of this disease. Endogenous lipid mediators are involved in the regulation of a variety of inflammatory processes, including initiation, maintenance, and regression, and eicosanoids and pro-decomposition lipid mediators, as well as their complex metabolic pathways and transduction signals, play a key role in the regulation of these processes. This article reviews the key role of endogenous lipid mediators in the pathophysiological mechanism of inflammation and immune dysfunction in liver failure and the potential significance and new therapeutic opportunities of lipid immune pathway in liver failure, in order to provide new ideas for the clinical diagnosis and treatment of liver failure.
2.Association between glycolysis and mitochondrial dysfunction and its potential value in liver diseases
Gengjie YAN ; Yong LIN ; Huiji SU ; Hanxiao CHEN ; Shaoqun BAN ; Ailing WEI ; Dewen MAO ; Fuli LONG
Journal of Clinical Hepatology 2022;38(8):1931-1936
Glycolysis plays an important role in the development and progression of liver diseases and shows varying degrees of enhancement in different liver diseases, and it is closely associated with mitochondrial dysfunction (oxidative phosphorylation deficiency and reactive oxygen species production), which helps to fill energy production deficiency caused by impaired oxidative phosphorylation. Therefore, it might be possible to search for potential new therapies for liver diseases through targeted regulation of the key factors in aerobic glycolysis, such as hexokinase 2, pyruvate kinase M2, and other regulatory pathways. From the perspective of the association between glycolysis and liver diseases, this article elaborates on the therapeutic significance and potential value of glycolysis in liver diseases, in order to provide new ideas for the diagnosis and treatment of liver diseases.
3.Role of macrophage polarization and its crosstalk with neighboring cells in hepatocellular carcinoma
Huiji SU ; Gengjie YAN ; Hanxiao CHEN ; Shaoqun BAN ; Ailing WEI ; Dewen MAO ; Fuli LONG
Journal of Clinical Hepatology 2023;39(5):1204-1211
Inflammation is closely associated with the development of cancer. Tumor-associated macrophages (TAM) actively participate in tumor-related inflammation and promote tumor growth and metastasis, while under certain conditions, TAM also show cytotoxicity and tumor killing activity and thus inhibit the progression of cancer. Crosstalk between TAM and neighboring cells is closely associated with the progression of hepatocellular carcinoma (HCC) and drug resistance during treatment. This article summarizes the role of macrophages in HCC and the crosstalk between macrophages and other cells, so as to provide new strategies for the clinical diagnosis and treatment of HCC.