1.A COMPARATIVE STUDY OF PSS AND TROXERUTIN IN THE TREATMENT OF PSEUDOBULBAR PARALYSIS
Chinese Journal of Marine Drugs 1994;0(04):-
152 patients with pseudobulbar paralysis resulting from ischemic cerebral infarction were treated with polysaccharide sulphate (PSS) or Troxerutin (TR) and their clinical curative effect and laboratory parameters were studied. 76 patients (M46,F30,mean ages 62+6 y),were treated with PSS:PSS 150 mg in 5% Glocose Solution 500 mL iv. drip. qd,for 14 days as a course. The other 76 patients (M46,F30,mean age 63 + 7 y) were treated with (TR);TR 600 mg in hydroxyethyi-starch 500 mL iv. drip ,qd .for 14 days as a course. The results showed that the total effective rates of the two groups were 94. 74% and 77. 63% .respectively. Moreover the plasma levels of cholesteral and triglyceride were decreased significantly ( P
2.Clinical progress of bendamustine in the treatment of lymphoma and leukemia
Journal of Leukemia & Lymphoma 2013;22(8):456-461,465
Bendamustine is a kind of nitrogen mustard derivatives consisting of a 2-chloroethylamine alkylating group and a benzimidazole ring.This special structure grants its anti-cancer mechanism different from other common alkylating agents with double function.Since approved,bendanustine has been widely used to treat henatologic malignancies and solid tumors such as breast cancer.In 2008,the FDA approved bendamustine injection for the treatment of chronic lymphocytic leukemia and indolent B cell non-Hodgkin's lymphoma.In recent years,scholars in China and abroad have carried out a series of clinical researches on single bendamustine and bendamsutine combinational chemotherapy,especially in hematologic malignancies,which obtained certain clinical efficacy.In this paper,the pharmacological actions,pharmacokinetics and clinical progress of bendamustine in lymphoma and leukemia are reviewed.
3.Application of extracorporeal membrane oxygenation on organ donation after cardiac death
Feng HUO ; Peng LI ; Shaoping WANG
Chinese Journal of Digestive Surgery 2013;12(9):648-651
The donated organ after cardiac death would undergo warn ischemia injury inevitably,and the incidences of primary non-function of donated organs,transplanted organ loss and ischemic-type biliary lesions were increased.It is a paramount research dilemma to devise how to avert,lessen and recover the warm ischemia organs after donation of cardiac death (DCD).Since February 2009,the Liver Transplantation Center of Guangzhou General Hospital of Guangzhou Military Command of PLA has applied the extracorporeal membrane oxygenation (ECMO) to protect the organs of DCD.The mechanism of recovering the donors from warm ishemia by ECMO has good prospects in the field of international organ donation,and it is an important method to solve the problem of donor shortage in China.Spreading the application range of ECMO in DCD and establishing the standard procedures and techniques in China is of great importance.
4.Minimally invasive managements for non-anastomotic biliary stricture after orthotopic liver transplantation
Shaoping WANG ; Yujian ZHENG ; Feng HUO
Chinese Journal of Digestive Endoscopy 2014;31(12):695-698
Objective To evaluate the clinical value of minimally invasive methods for non-anastomotic biliary stricture (NABS) after orthotopic liver transplantation.Methods The clinical data of 403 patients who underwent liver transplantation during recent 10 years in Liver Transplantation Center at General Hospital of Guangzhou Military Commanmol were analyzed retrospectively,and 13 patients with NABS were selected.The outcomes of 3 types of NABS patients treated by endoscopic retrograde cholangiopancreatography(ERCP) or percutaneous transhepatic cholangial drainage(PTCD) were compared and the indication for re-transplantation was identified.Results PTCD treatments of 4 patients were proved ineffective.The shortterm curative rate of minimally invasive treatments was 8/13.Five patients eventually required surgical treatments (re-transplantation in 4,Roux-en-Y anastomosis in 1).According to cholangiography results,NABS were divided into 3 types,namely hepatic bile duct strictures (n =4,type Ⅰ),multiple extra-hepatic and intrahepatic biliary strictures (n =7,type Ⅱ),intrahepatic biliary strictures (n =2,type Ⅲ).The success rates of minimally invasive treatment in 3 types of NABS were 3/4,4/7 and 1/2,respectively.Nearly half of type Ⅱ and type Ⅲ patients needed re-transplantation,which was more likely for those patients with hepatic artery stenosis (2/3).Conclusion NABS treated with minimally invasive methods are preferred.Based on the appearance of biliary stricture,type Ⅰ patients had the best prognosis.For those type Ⅱ and type Ⅲ patients who failed minimally invasive treatment,especially combined with hepatic arterial stenosis,surgical treatment should be timely,so as not to lose a chance for re-transplantation.
5.A prospective study of the HEART scores' value in diagnosing acute coronary syndrome in the chest pain center
Xu WANG ; Shaoping NIE ; Zhechun ZENG
Chinese Journal of Emergency Medicine 2015;24(7):725-728
Objective To study the value of HEART scores in predicting the risk of getting acute coronary syndrome in patients with chest pain and assessing the prognosis in order to elucidate the validity of the HEART scores.Methods A total of 1 200 patients with chest pain were continuously observed and followed up,and their HEART scores were calculated.The survival rates were calculated with Kaplan-Meier method and AUROC (area under ROC curve) was used to determine the accuracy of this methods.The HEART scores were compared with TIMI and GRACE scores.Results Low HEART scores (0-3) were found in 34.5% of the patients and MACE (major adverse cardiac event) occurred in 1.4% of them.The patients with intermediate HEART scores (4-6) accounted for 50.7% patients,and MACE was diagnosed in 22.2% of them.High HEART scores (7-10) were found in 14.85% patients,and MACE occurred in 60.7% of them.There was significant difference among these three groups (Log rank P < 0.01).The AUROC of HEART score was 0.83 (95% CI:0.80-0.85,P <0.01),being significantly higher than the GRACE scores (0.76) and TIMI scores (0.72).Conclusions The HEART score is applicable for predicting the risk of getting acute coronary syndrome of chest pain patients in emergency department and the prognosis.
6.Diagnosis and treatment of latent perforation of peptic ulcer during laparoscopic cholecystectomy
Shilin ZHAN ; Jianxiong CHEN ; Shaoping WANG
Chinese Journal of Minimally Invasive Surgery 2001;0(01):-
Objective To investigate the diagnosis and treatment of latent perforation of peptic ulcer (LPPU) during laparoscopic cholecystectomy (LC). Methods A retrospective analysis was made on clinical data of 13 cases of LPPU diagnosed during LC from January 1994 to November 2005. Results All the 13 cases were misdiagnosed before the LC and clarified as having LPPU during the LC. Three cases of anterior duodenal bulbar perforation (0.4~0.5 cm in size) were laparoscopically repaired, whereas conversions to open repair were performed in 5 cases of duodenal perforation (0.5~1 cm in size) and 5 cases of gastric perforation (0.6~1 cm in size) because of severe adhesion or difficult performance. No surgical complications occurred. Twelve cases were followed for 6~36 months (mean, 27 months). The symptoms disappeared and gastroscopy showed healed ulcer. No recurrence of perforation was found. Conclusions Underestimation of LPPU leads to misdiagnosis, and preoperative gastrosopy can prevent it. For small perforation, laparoscopic repair and abdominal drainage can be employed. But in most cases, a conversion to open surgery is required. It is necessary to give regular internal medicine for peptic ulcer after operation.
7.AN ANALYSIS OF THE FEATURES OF PRE-HOSPITAL SUDDEN DEATH
Shaoping SU ; Hong SHEN ; Yu WANG
Medical Journal of Chinese People's Liberation Army 1981;0(04):-
In order to decrease the mortality of pre-hospital sudden death events(SDEs),their features especially those of cardiac sudden death were analyzed. 1030 pre-hospital emergent cases from 1973~1999 were analysed systematically. The total SDEs occurred in 106 cases, among the 68 cases of cardiovascular diseases, 89.7% had coronary heart diseases(CHD), AMI or OMI with re-infarction. There were two peak age stages of SDEs: the first was 46-55 years old stage(non-retaired age stage,22.6%), and the second stage was 66-75 years old(27.3%). The pre-hospital SDEs are the most emergent cases. Great attention must be paid to those with the history of cardiovascular diseases, especially those with the history of coronary cardiac events
8.The clinical significance of intrahepatic arteriovenous shunt in patients with hepatic carcinoma
Shaoping WANG ; Weidun XU ; Feng HUO
Chinese Journal of General Surgery 1993;0(02):-
Objective To investigate the clinical features of intrahepatic arteriovenous shunt(AVS) in patients with hepatic carcinoma. Method The clinical data including results of therapy of 538 hepatic carcinoma patients admitted between 1996 and 2001 were retrospectively reviewed. Results There were 71 cases of AVS altogether with 61 cases of arterio-portal shunt and 8 cases of hepatic arterio-venous shunt. Thirty out of 39 AVS cases with fistula formed between hepatic artery and main portal branch developed portal hypertension. The patients received a total of 84 sessions of transarterial chemotherapy and embolization(TACE) with a success rate of 61%(51 sessions).After TACE liver failure ensued in 3 cases. The mean survival time of these patients was 5.77 months. Conclusion Arterio-portal/venous fistula is a common complication among hepatic carcinoma patients which often predicts poor prognosis. A high percentage of AVS patients will not tolerate TACE and in which the portal hypertension will be exacerbated.
9.A comparison between ultrasound-guided interventional therapy and open or laparoscopic therapy for paraovarian cysts
Liming WANG ; Qingzhao FU ; Shaoping LIU
Chinese Journal of Minimally Invasive Surgery 2001;0(05):-
Objective To study the feasibility of ultrasound-guided interventional therapy for parovarian cysts. Methods Diagnostic characteristics of 82 patients preoperatively diagnosed as having parovarian cysts were analyzed, and their clinical parameters were compared between 27 patients receiving ultrasound-guided interventional therapy and 55 patients receiving open or laparoscopic operations. Results Ultrasound examination was the principal means of diagnosis of parovarian cysts. The diagnostic accordance rate was 95.3% (82/86). The operative time, intraoperative blood loss and hospitalization costs in patients receiving ultrasound-guided intervention significantly decreased as compared with those receiving open or laparoscopic operation ( t =-20 798, 65 356, -184 533 , respectively; P =0 000). There were no significant differences in the postoperative recurrence rate and pyrexia rate between the two groups ( ? 2 =0 000, P =1 000; ? 2 =0 373, P =1 000). Conclusions Ultrasound-guided interventional therapy for parovarian cysts is feasible and offers satisfactory effects.
10.Tianshu Capsule for treatment of migraine
Huanmin GAO ; Yaoquan LIU ; Shaoping WANG
Chinese Traditional Patent Medicine 1992;0(05):-
AIM: To compare the clinical effect of Tianshu Capsule(Rhizoma Chuanxiong,Rhizoma Gastrodiae,efc) on migraine with Flunarizine. METHODS: 82 cases of patients with migraine were divided randomly into the treatment group(40 cases),which were treated with oral Tianshu Capsule,4 capsules(1.36 g),3 times daily after meals,and the control group(42 cases),which were treated with Flunarizine(Sibelium) 5 mg quaque nocte,for 2 months.One year follow-up was carried out.The frquency and duration of migraine were analyged before and after treatment,and duration of positive results after withdraw of drugs were also recorded.The body weight,blood and urine routine,liver and kidney function as well as electrocardiograph were compared before and after treatment. RESULTS: In the treatment group the frequency and duration of migraine decreased more than that of control group.The positive results remained longer in the Tianshu Capsule group(P