Background and purpose:Resistance to anticarcinogen is one of the key factors that affect the treatment efficiency in lung cancer. The purpose of this study was to investigate the clinical significance of the multidurg resistance-related proteins P-gp, multidrug resistance-related proteins(MRP),lung resistance associated protien(LRP) and GST-?by detecting their expression in lung cancer and to investigate the mechanism of resistance to anticarcinogen. Methods:S-P immunohistochemistry was used to examine the expression level of proteins P-gp, MRP, LRP and GST- ?in 226 samples of lung cancer and 23 samples of normal lung tissues. Results:The positive rates of P-gp, MRP, LRP and GST-? in lung cancers were 46.0%, 42.0%, 54.4%, 62.4% respectively. Significant difference existed between tumorous tissue and normal lung tissue (17.4%, 13.0%, 17.4%, 21.7%). The positive rates of P-gp, MRP, LRP and GST-? in poorly differentiated-type of NSCLC were 33.3%, 22.8%, 33.3%, 47.4%, compared with differentiated-type of NSCLC (59.7%, 58.1%, 73.6%, 79.1%) (P

The physiological function of postoperative patients had not returned to normal, coupled with surgical trauma, residual effects of anesthesia and analgesic drugs and potential risk factors, so postoperative patients need to be transferred to the post-anesthesia care unit for observation, until the vital signs were stable before being transferred to the general ward. This paper summarized the importance, safety management status, influencing factors and intervention measures of patient handover between operating room and post-anesthesia care unit, to provide guidance for clinical patient handover and improve the safety of patient handover.

This article reviews the current status, assessment tools, influencing factors, and intervention measures of self-management behavior of intestinal symptoms in patients with rectal cancer undergoing anal preservation surgery, in order to provide reference for further research and nursing practice on self-management of intestinal symptoms after rectal cancer anal preservation.