Objective To study the distribution and antimicrobial activity of marine actinomycetes from Jiaozhou Bay and to estimate its application potentials.Methods The strains were isolated using gradient dilution and streak plate techniques and the activity was determined by Oxford cup method and paper disk method.Results 516 strains of marine actinomycetes were isolated from various places along Jiaozhou Bay;The rates of active strains determined by both methods were 22.3% and 50.0%,respectively.Conclusion The estuary was rich in marine actinomycetes resources; paper disk method was a better method in screening active strains of marine actinomycetes.The results from both determination methods showed a good exploitability of the marine actinomycets from Jiaozhou Bay.

Objective:In order to detect blood oxygen saturation timely,accurately,and conveniently,a wireless blood oxygen saturation detection module has been developed.Methods:Based on wearable monitoring technology and ZigBee wireless communication technology,we designed a blood oxygen saturation module of finger cuff type.This system is composed of photoplethysmography detection micromodule,ZigBee access terminal,and data analysis program,which realize the functions of waveform display,SpO2 calculation,wireless date transmission and so on.Results:The results show that detection accuracy of photoplethysmography is 98%,and calculating error of SpO2 is less than 8.8% satisfying the performance index of blood oxygen saturation detection.Furthermore,ZigBee wireless communication technology and light source regulator can reduce energy expenditure effectively.Conclusion:With the characters of wireless,low power consumption,miniaturization,and high performance,it can truly reflect physiological condition of patients,and remove lines on them,which make it possible for mobile monitor.

Phonocardiogram contains a lot of information on the physiological and pathological cardiac function, so it can improve the diagnosis and treatment of cardiovascular disease to effectively diagnose cardiac sounds. This paper presents the design of a computer-based measurement and real-time analysis system of heart sounds. Applying computers to the analysis and auxiliary diagnosis of cardiac sounds, the system is real-time and intelligent.

OBJECTIVE:To provide the support for pharmacists in their clinical pharmaceutical care.METHODS:The hospital pharmaceutical care system was set up by employing Visual FoxPro6.0and developing series of database according to the characteristics of clinical pharmacy.RESULTS&CONCLUSION:This system has the characteristics of convenience,flexibility,and fastness,which can result in more scientific and accurate pharmaceutical care.

Objective To investigate the rituximab plus bendamustine (R-Benda) therapeutic effect for relapsed extragastric mucosa-associated lymphoid tissue (MALT) lymphoma.Methods Ten patients (three females and seven males) with relapsed extragastric MALT lymphoma undergoing therapy with R-Benda were defined.Bendamustine was given at a dose of 90 mg/m2 on days 2 and 3 in nine patients and at 70 mg/m2 in one patient, while all received 375 mg/m2 rituximab on day 1.Results Nine patients received six courses of therapy,while one patient discontinued therapy after five courses for personal reasons, while one elderly patient had progressive disease after three courses.Tolerance of therapy was excellent, and all except one patient responded.Eight patients achieved the complete remission, one achieved the partial remission, and one patient progressed.Toxicities were mild and mainly hematological.After a median follow-up of 24 months (range, 5-43 months), 9 patients were alive.Conclusion R-Benda regime has high activity and good tolerance for patients with relapsed extragastric MALT lymphoma.

Objective To: analyze the operator learning curve of prostatic artery embolization (PAE) in treatment of prostatic hyperplasia (PH). Methods: Data of the first to 60th PH patients treated with PAE by the same operator having more than 5 years' experiences of peripheral vascular interventional therapy were retrospectively analyzed. The patients were divided into groups A, B and C according to the treatment order (each n=20). PAE operation time, intraoperative X-ray exposure time and post-operation hospitalization were compared among groups. International prostate symptom score (IPSS) and quality of life score (QOL), prostate volume, maximum flow rate (Qmax) and post void residual (PVR) before and after operation were analyzed. Results: There was no statistical difference of prostate volume, IPSS score, QOL score, Qmax nor PVR among three groups before PAE (all P>0.05).There were significantly statistical differences of operation time and intraoperative X-ray exposure time (F=32.74, 13.57, both P<0.01) among 3 groups. Pairwise comparison showed the operation time and intraoperative X-ray exposure time in group A were significantly longer than those in group B (both P<0.01) and group C (both P<0.01), while the differences between group B and C were not statistical (P=0.22, 0.30). No statistical difference of post-operation hospitalization was found among 3 groups (F=0.17, P=0.84). Three months after PAE, IPSS score (t=14.66, 11.74, 29.02), QOL score (t=8.51, 8.19, 7.99), PVR (t=11.68, 12.71, 16.80) and prostate volume (t=14.75, 17.45, 27.42) decreased compared with those before operation in all 3 groups (all P<0.01), and Qmax (t=-11.72, -10.80, -7.74) also statistically increased (all P<0.01). Conclusion: PAE is effective for PH in short-term. After accumulating 20 cases of PAE operation experience, the operation time and X-ray exposure are significantly shortened, and the learning curve turn to the plateau stage.

Motion artifact is a significant source of noise in ambulatory physiologic signals and can affect the diagnoses seriously. To cope with this problem, we adopted certain methods for removing motion artifact from ECG signals via synchronous acquisition of the elector/skin impedance as the reference signal of adaptive filter. The results demonstrated that 3rd order RLS adaptive filter can remove the baseline shift effectively with an exciting current of 120 Hz and 50 microA. Such system was implemented to investigate the utility of ambulatory heart rate monitoring, which provides convenient and reliable monitoring services for patients.
Algorithms ; Artifacts ; Electric Impedance ; Electrocardiography ; methods ; Humans ; Signal Processing, Computer-Assisted

ObjectiveTo investigate the clinical application of ultrasound-guided mammotome surgery in breast tumor.Methods579 breast tumors from 273 patients underwent minimally invasive surgery by ultrasoundguided mammotome system.ResultsThrough 0.5cm incisal opening,all tumors were exactly,completely resected and no infaust surgery complication happened.ConclusionThe way of minimally invasive surgery of breast tumor by ultrasound-guided mammotome system was simple,precise,safe,minimally invasive and was accurate diagnosis.So popularizing this minimally invasive techniques was deserved.

Objective To study the changes of endothelin,nitric oxide and vascular endothelial growth factor level in patients with type 2 diabetic retinopathy (DR). Methods Eighty diabetes patients (53 with diabetic retinopathy and 27 without). Another 30 healthy volunteers were recruited as control. Plasma ET and VEGF levels were measured by enzyme-linked immunosorbent assay. NO levels were measured by nitrate reductase method. Results Plasma levels of ET were higher in patients with type 2 diabetes with DR (DR)(80. 68 ± 13.57) mg/L than (65. 33 ± 11.24) mg/L, (45.25 ±9. 06) mg/L, in control and in type 2 diabetes patients without DR (NDR) (Ps ＜ 0, 01 ). Plasna levels of NO in DR group (69. 82 ± 14. 89) μmol/L were higher than (37. 85 ±-9. 11 ) μmol'L, in control group,but lower than (77.52 ±± 18.56) μmol/L in NDR group (Ps ＜ 0. 05 ). Plasma levels of VEGF ( 110. 52 ± 25.65 ) μg/L in DR were significantly increased compared with control (82.42 ± 18. 47 ) μg/L, and NDR(97.55 ±25.61)μg/L, (Ps ＜0.05).Conclusion ET, NO and VEGF may be involved in the pathogenesis of type 2 diabetic retinopathy.