Objective To explore the effect of comprehensive geriatric assessment on the prevention of falls in hospitalized older patients with mental disorders.Methods A total of 150 elderly patients with mental disorders admitted into our hospital from June 2017 to May 2018 were randomly divided into the conventional group (n =75)and the comprehensive geriatric assessment group(n=75).The conventional group received routine nursing interventions based on risk evaluation via the Morse scale,and the comprehensive assessment group adopted targeted nursing interventions based on comprehensive assessment outcomes.The detection rate of risk for falls,the incidence of falls,the compliance with prevention measures and the satisfaction level of nursing services were compared between the groups.Results The detection rate of risk for falls was higher (80.0％ vs.45.3％,x2 =19.263,P=0.000),the incidence of falls was lower(1.3％ vs.9.3％,x2 =4.754,P =0.029),and the compliance with prevention measures(93.3％ vs.82.7％,x2 =4.040,P =0.044) and the satisfaction level of nursing services(96.0 ％ vs.86.7％,x2=4.127,P =0.042)were higher in the comprehensive assessment group than in the routine group.Conclusions Comprehensive geriatric assessment has a forewarning effect on falls in hospitalized older patients with mental disorders.Targeted nursing interventions can help reduce the incidence of falls and improve the satisfaction level of nursing care.