Objective To evaluate the clinical effect of treating intractable rotavirus enteritis with Wenpi Yiyang Decoction. Methods Sixty cases with intractable rotavirus enteritis were recruited in this study and divided into a treatment group and a control group randomly.Traditional Chinese drugs of warming spleen and invigorating yang were adopted in the treatment group(30 cases).Results The total effective rate was 93% in the treatment group and 49% in the control group.There was no significant statistical difference between two groups(P＜0.05).Conclusion There was good clinical effect of treating intractable rotavirus enteritis with Wenpi Yiyang Decoction.