Objective To explore clinical characteristics and the perinatal effects of multiple systems in pre-pregnancy obesity patients with early-onset preeclampsia. Methods A total of 111 cases with early-onset preeclampsia in our Inpatient Obstetric Department were reviewed in this study. According to pre-pregnancy body mass index (BMI), patients were divided into normal before pregnancy group (BMI<28 kg/m2, n=56) and obese before pregnancy group (BMI≥28 kg/m2, n=55) . The body weight, BMI, weight gain during pregnancy, risk factors, clinical features, and clinical features of neonatal index were compared between two groups. The correlation between maternal and neonatal indexes and glucose and lipid indexes were compared. Results Obese before pregnancy was more prone to blood concentration and disorders of lipid metabolism. The serum levels of lipid, glycosylated hemoglobin (HbA1c), hematocrit, platelet and fibrinogen were significantly higher in obese before pregnancy group than than those of normal group. The induced neonatal acidosis and other organ damage, newborn Apgar score, pH, glucose were significantly lower in obese before pregnancy group than those of normal group. The residual alkali (BE), lactic acid (LAC), creatine kinase (CK) and creatine kinase (CKMB) were higher in obese before pregnancy group than those of normal before pregnancy group. Correlation analysis showed that maternal low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), three acyl glycerol (TG) and HbA 1c were negatively correlated with neonatal Apgar score and pH, and which were positively correlated with neonatal LAC and CKMB. Both differences were significant (P<0.05 or P<0.01). Conclusion The dyslipidaemia in early onset preeclampsia in obesity patients before pregnancy is closely related with maternal and perinatal outcomes.

Objectie:To study the protective effects and mechanism of Huoxuetongmailing(HXTML) on experimental myocardial ischemic rats by zhuodu.Methods 50 healthy male Wister rats were randomly divided into groups namely blank group,model group,Cedocard group,HXTMLmax and HXTMLmin group,10 rats in each group.Each rat had been recordⅡelectroca rdiographic(ECG) before the experiment.Hyperlipemic forage was feeded and ISO was subcutaneously injected into rats except Blank group to cause myocardial ischemia.Blank group and model group,respectively,the volume of normal saline irrigation,etc.,and the rest of the group were irrigated isosorbide dinitrate,HXTMLmax and HXTMLmin dose treatment.After treatment,the myocardium zymogram(CK,CK-MB and LDH) and inflammatory factor were detected by modern medical method.Results:HXTMLmax and HXTMLmin dose could signifi cantly reduce the levels of serum enzymes(P

OBJECTIVE:To study the bioequiavailability of sodium/calcium folinate for injections in healthy volunteers.METHODS:By a randomized crossover design,trichloracetic acid was used to precipitate the protein in serum sample.Serum concentration of folinate was determined by RP-HPLC.The pharmacokinetic parameters and relative bioavailability of sodium folinate for injection vs.calcium folinate for injection were computed and analyzed statistically.RESULTS:The pharmacokinetic parameters of single dose of sodium folinate for injection(trial formulation)vs.calcium folinate for injection(reference formulation)were as follows:tmax(0.292?0.096)h vs.(0.25?0)h;Cmax(31.973?4.337)?g?mL-1 vs.(33.332?3.312)?g?mL-1;AUC0～24(139.670?13.859)?g?h?mL-1 vs.(144.401?13.574)?g?h?mL-1;AUC0～∞(154.246?16.481)?g?h?mL-1 vs.(161.306?17.871)?g?h?mL-1;MRT0～24(6.795?0.73)h vs.(6.963?0.713)h;t1/2(7.183?1.469)vs.(7.316?2.045).The mean relative bioavailability of the sodium folinate for injection was(98.2?37.1)%.CONCLUSION:The two formulations are proved to be bioequivalent.

Objective To explore the best time of initiating enteral nutrition for patients after thoracoscopic resection of esophageal cancer and impacted on Prognosis. Methods A total of 202 esophageal cancer patients were treated in Department of Thoracic Surgery Fujian Medical University Union Hospital, who were divided into experimental group ( n =88 ) and control group ( n =114 ) by random number table and received enteral nutrition 8-12 h and 24-48 h respectively after operation. At 1 d before operation, 5 d, 8 d after operation, we compared the main nutrition indexes of blood chemistry, and observed the effects of clinical nutrition support and incidence of complications. Results Five days after operation, the total protein and albumin of experimental group were (57. 44 ± 4. 61), (29. 53 ± 3. 05) g/L higher than (53. 58 ± 5. 22), (27. 13 ± 3. 27)g/L of the control group (t=5. 48, 5. 33;P<0. 01); they were (63. 30 ± 4. 80),(32. 33 ± 3. 88)g/L in the experimental group higher than (57. 42 ± 5. 73), (29. 75 ± 3. 66) g/L in the control group (t=7. 75, 3. 35;P<0. 01). The incidence rate of complication in two groups had no statistical significance (P>0. 05). There were 24 cases complications in the control group and 16 cases in the experimental group (χ2 =0. 26,P=0. 612). The discomfort patients of gastrointestinal tract was 26 in the control group while it was 21 persons in the experimental group (χ2 =0. 03,P=0. 860). Conclusions The best time of enteral nutrition after operation is 8-12 hours, which can improve the nutritional status of patients and decrease postoperative complications with the clinical feasibility.

Objective To investigate the correlation between the level of circulating placental growth factor(PLGF)and the severity of preeclampsia(PE),maternal and infant outcomes and placental pathology.Methods A total of 159 PE patients were selected as the study subjects and divided into the PE1 group(62 PE patients with termination of pregnancy<34 weeks)and the PE2 group(97 PE patients with termination of pregnancy≥34 weeks)according to the gestational age of pregnancy termination.A total of 107 non-PE patients who gave birth during the same period were selected as the control group.Patients were divided into two groups according to the gestational age of termination:the non-PE1 group(41 non-PE patients with termination of pregnancy at<34 weeks)and the non-PE2 group(66 non-PE patients with termination of pregnancy at≥34 weeks).General data were collected in each group of pregnant women,including age,body mass index(BMI),admission systolic blood pressure,diastolic blood pressure,24 h urinary protein quantity,gestational times,presence of FGR and fetal embarrassment.General information of newborns during the operation were collected,for example,whether there was fecal contamination of amniotic fluid,neonatal asphyxia,and days of newborn stayed in NICU.PLGF in venous blood of pregnant women was detected on the day of delivery.The placenta was pathologically detected and scored.After delivery,blood gas of umbilical artery was analyzed,and PH(pH),base surplus(BE),lactic acid(LAC)were recorded.Results There were no significant differences in age,gestational times and delivery times between the PE1 group and the PE2 group and the corresponding the non-PE1 group and the non-PE2 group.BMI was higher in the PE1 group and the PE2 group than that in the non-PE1 group and the non-PE2 group.PLGF was lower in the PE1 group and the PE2 group than that in the non-PE1 group and the non-PE2 group,respectively,and PLGF was lower in the PE1 group than that in the PE2 group(P＜0.05).The 24 h urinary protein quantity,systolic blood pressure,diastolic blood pressure and pathological changes of placenta were higher in the PE1 group than those in the PE2 group(P＜0.05).There were no significant differences in fecal staining of amniotic fluid,fetal embarrassed condition and pH value of umbilical artery blood gas during delivery between the PE1 group and the PE2 group.Compared with the PE2 group,the proportion of neonatal asphyxia and FGR,the umbilical artery blood gas LAC were increased,the BE value was decreased,and the time of staying in NICU was prolonged in the PE1 group(P＜0.05).Conclusion The level of circulating PLGF is decreased in patients with preeclampsia.PLGF has certain value in evaluating PE and predicting adverse pregnancy outcome.