Objective:To observe the clinical effects of autologous fat transplantation combined with liposuction in buttock shaping.Methods:January 2020 to January 2021, fifty-eight female patients (aged 21-36 years) with hip depression, hip prolapse, obvious inferior plica and fat hypertrophy of buttocks were treated in the clinic of medical cosmetology of Hangzhou Tongrong Lige Medical Technology Co., Ltd., the average age is 29. There were 20 cases of waist-abdomen liposuction + hip shaping, 18 cases of thigh liposuction + hip shaping, 16 cases of thigh liposuction + hip shaping, and 4 cases of simple hip shaping. All patients were followed up for 3-12 months to observe the shape of buttocks and complications (hematoma, infection, fat liquefaction).Results:A total of 58 patients were followed up for 3-12 months. Among the 58 patiens, 45 patiens had significant effect, 11 patients had good effect, and 2 patients had poor effect. Of the 11 cases with good results, 6 cases had poor hip shape and 5 cases had slight symmetry of the lateral buttocks. The reason was that the patients′ buttocks were flat and needed 2-3 times of filling. The buttocks were filled again one year after operation, and better results were achieved. No complications such as infection, hemmatoma, fat liquefaction and uneven bump occurred.Conclusions:The patients are satisfied with the shape of the buttocks after autologous fat transplantation combined with liposuction in buttock shaping. The incidence of surgical complications is low.