Objective To compare the effect of different fracture fixation in the treatment of patients with Colles fracture.Methods 120 patients with Colles fracture were randomly divided into the study group and control group,6 0 cases in each group.The control group received the manipulative reduction and external fixation frame,while the study group was treated with open reduction and plate fixation of implementation.The fracture prognosis and the incidence of complications were recorded and compared.Results The total effective rate of the study group was 93.3％,the total effective rate of the control group was 91.7％,there was no statistically significant difference between the two groups (x2 =2.083,P ＞ 0.05).The obvious effective rate of the study group was 83.3 ％,that of the control group was 66.7％,the difference was statistically significant(x2 =5.436,P ＜ 0.05).The incidence rate of complications between the two groups had no significant difference [3.3％ (2/60) vs 8.3％ (5/60),P ＜ 0.05].Conclusion The two plans in the treatment of Colles fracture had similar clinical effect,patients who unwilling to accept operation treatment can be given manipulative reduction and external fixation,if there is comminuted fracture,the open reduction and plate fixation should be implemented.