1.Influencial Factors of Early Treatment on Patients with Acute Stroke
Chinese Journal of Rehabilitation Theory and Practice 2007;13(2):125-127
ObjectiveTo investigate the factors influencing early treatment of patients with acute stroke.Methods300 patients with acute stroke were investigated with questionnaire which including 28 factors influencing patients receiving early treatment.Results41.5% of patients were admitted within 6 hours after onset. The responses after onset, the time to the special hospital after stroke, and whether being able to describe symptoms and style of stroke correctly were independent influencing factors. Other factors such as age, sex and stroke severity had not obvious influence to admission delay.ConclusionEffective public health programs and establishment of effective emergent medical service system are measures to minimize the admission delay.
2.A case of milk protein allergy-induced eosinophilic gastritis.
Chinese Journal of Pediatrics 2010;48(8):634-635
Eosinophils
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immunology
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Food Hypersensitivity
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etiology
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Gastritis
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etiology
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Humans
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Infant
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Male
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Milk Hypersensitivity
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complications
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immunology
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Milk Proteins
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immunology
3.The relationship between homocysteine, polymorphism of its enzymes and cerebral thrombosis
Yan SHAO ; Chengguo ZHANG ; Jinhuan CUI
Chinese Journal of Rehabilitation Theory and Practice 2005;11(8):601-604
ObjectiveTo explore the relationship between plasma homocysteine (Hcy), polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR) and cystathionine-β-synthase (CBS), and cerebral thrombosis.Methods87 subjects with first-ever acute cerebral thrombosis and 80 controls were studied. The plasma Hcy levels were measured using high-performance liquid chromatography-fluorescence detection (HPLC-FD). The polymorphism in MTHFR was determined by a polymerase chain reaction (PCR) assay and subsequent restriction enzyme digestion and that in CBS was determined by amplification refractory mutation system (ARMS).ResultsThe fast plasma Hcy level in the patient group was (15.28±4.33)μmol/L significantly higher than that ( 11.32 ±3.86)μmol/L in the control group (P<0.001). Different genotype had different influence on the plasma Hcy levels. There were no differences in genotype frequencies or allele frequencies between the patient group and control group (P>0.05).ConclusionCommon mutations in MTHFR, CBS G919A and CBS T833C lead to hyperhomocysteinemia. Hyperhomocysteinemia, but not common mutations in MTHFR and CBS is associated with the increased incidence of cerebral thrombosis.
4.Perioperative nursing of abdominal surgery in patients over 80 years old
Huifang ZHANG ; Baocun LING ; Yan SHAO
Chinese Journal of Primary Medicine and Pharmacy 2009;16(1):85-86
Objective To analyze the handling measure in period of ambo-operation and postoperative care of patients with abdominal surgery in advanced age over 80 years. Methods A retrospective analysis of 102 integrity data of patients with abdominal surgery in advanced age over 80 years was done. Results 100 patients recovery and discharged. The incidence of postoperative complications was 55.9% (55/102). Postoperative death was oberserved in two patients. Conclusion In patients over 80 years old,handling measure in period of ambo-operation is very impor-tant. Degeneration of organ function and more comorbidities made operation more dangerous. A well preoperative prep-aration and postoperative care, an intensive treatment of comorbiditius, the prevention of apoplexia and reducing the chance of emergency operation, will make operation more effective.
5.Relationship of plasma homocysteine, polymorphism in its enzymes genes and cerebral infarction in the elderly
Yan SHAO ; Chengguo ZHANG ; Xueqiang HU
Journal of Clinical Neurology 1992;0(01):-
Objective To study the relationship of plasma homocysteine (Hcy), polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR) and cystathionine-?-synthase (CBS) genes, and cerebral infarction in the elderly. Methods 61 elderly patients with first-ever acute cerebral infarction and 57 controls were studied. The plasma Hcy levels were measured using high-performance liquid chromatography-fluorescence detection (HPLC-FD). The polymorphism in MTHFR was determined by a polymerase chain reaction (PCR) assay and subsequent restriction enzyme digestion.CBS was determined by amplification refractory mutation system (ARMS). Results The fast plasma Hcy levels were higher in the patient group compared with those in the control group [(13.07?3.96)?mol/L vs (11.51?3.90)?mol/L, P 0.05). There were no differences in the plasma Hcy levels among the different genotypes. Conclusions The MTHFR, CBS gene mutations cannot lead to hyperhomocysteinemia in the elderly patients with acute cerebral infarction. Hyperhomocysteinemia is associated with the independent risk of cerebral infarction, however, mutations only in MTHFR and CBS cannot be ascertained to be independent risk of cerebral infarction in the elderly.
6.A study of the relationship between plasma homocysteine level and cerebral infarction
Chengguo ZHANG ; Yan SHAO ; Xueqiang HU
Journal of Clinical Neurology 1995;0(04):-
Objective To explore the relationship between plasma homocysteine(Hcy) levels and cerebral infarction.Methods 87 patients with acute cerebral infarction and 80 controls were enrolled in the study. Plasma Hcy levels were measured by high-performance liquid chromatography-fluorescence detection(HPLC-FD) technology using Baseling 810 type high-performance liquid chromatograph.Results Fast plasma Hcy levels were higher in the patient group[(15.28?4.33)?mol/L] compared with those in the control group[(11.32?3.86) ?mol/L]( P
7.The advantages and research progress of T cells of the chimeric antigen receptor in the treatment of primary tumors
Wei ZHANG ; Dandan YAN ; Li GAO ; Mingliang SHAO ; Huimin YAN
Tianjin Medical Journal 2016;44(2):253-256
Chimeric antigen receptor (Car) T cells, not only have the characteristics of strong specific recognition of tu-mor antigens, but also have destruction and high affinity advantages, thus receiving more attention. Although it has played a lot of advantages in anti-tumor, it still has some shortcomings, which needs to be further optimized to improve the safety of its clinical application. In this study, The cell structure and biological function, treatment process, application development and application risk of Car T cells are reviewed, which provide references for further clinical immunotherapy of Car T.
8.Rifaximin in Treating Acute Infectious Diarrhea:A Clinical Study
Suwen WANG ; Boxin ZHANG ; Shuhong ZHANG ; Lei SHAO ; Xin YAN
Chinese Journal of Nosocomiology 2005;0(11):-
OBJECTIVE To evaluate the clinical curative effect and safety of rifaximin in treating acute infectious(diarrhea).METHODS A multi-center randomized trial with double-blind double-analogue and parallel(-control) with positive drug was used.All the 240 chosen patients were classified into two groups.There were 120 cases in the trial group.On the first day,the patients received rifaximin 300mg tid.From the 2nd to 5th day,the patients(received) rifaximin 400 mg tid.There were 120 cases in the control group,on the first day,the patients received levofloxacin 100 mg tid;from 2nd to 5th day,they received levofloxacin 100 mg tid.The total therapeutic course was 3 to 5 days.RESULTS After 3-5 day treatment,symptoms such as ache in abdomen and diarrhea were(alleviated) or disappeared and stool examination was turned better or normally.To the trial group,the cure rate was 84.68%,the dominant effecive rate was 15.31%,and the total(effective) rate was 100.00%.The bacteria clearance rate was 100.00% in the trial group.There was no significant difference between two groups.There were no severe side effect in the two groups.CONCLUSIONS Rifaximin is an effective and safe drug for acute(infectious) diarrhea for adults.
9.Determination of Five Pesticides in Fishpond by SPE-GC/MS
Dawei LIN ; Yan ZHANG ; Honglei SUN ; Wenhai LI ; Kai SHAO
Journal of Forensic Medicine 2015;(1):41-43
Objective To establish the solid phase extraction (SPE) with GC/MS technology for fish poi-soning cases to determine five pesticides in fishpond. Methods By three solid phase extraction column including Oasis HLB cartridge, Bond Elut C18 and SampliQ C18, the recovery rate was compared to ex-tract and purify five pesticides in fishpond. The effects of different kinds and dosages of eluents on ex-tract rate were also reviewed. Results Using Bond Elut C18 as solid phase extraction column and 3 mL benzene as eluent, the linear range of mass concentration of five pesticides in fishpond was 1-50 μg/mL, and the correlation coefficient was 0.996 2-0.999 6. The limit of detection was 3.4-26 μg/L and the re-covery was 61.49%-102.48%. The relative standard deviations was less than or equal to 3.01%. Conclu-sion With high sensitivity, good accuracy and precision, SPE -GC/MS has simple and quick operation and less solvent. It can be applied to determination of five pesticides in fishpond.
10.Clinical Manifestations and Pathology of Progressive Myoclonus Epilepsy
Yan WANG ; Xiaoqiu SHAO ; Chengyun DING ; Zaiqiang ZHANG
Chinese Journal of Rehabilitation Theory and Practice 2010;16(8):768-770
Objective To explore the various types of progressive myoclonus epilepsy seizure characteristics, diagnostic strategies, and pathological features.Methods12 cases of progressive myoclonus epilepsy were analyzed with the clinical characteristics, the routine laboratory examinations, the pathological examination by light and electron microscopy to extra cranial.Results12 cases carried out routine examinations, neural electrophysiological examinations and physical examinations. The result showed that there 5 patients diagnosed with Neuronal Ceroid Lipofuscinoses, 5 patients with MERRF, 1 patient with Lafora Disease, 1 patient with Unverricht-Lundborg disease.ConclusionProgressive myoclonus epilepsy is a group of rare myoclonus epilepsy syndrome. It can be early diagnosed and properly classified with detailed medical history, characteristics of the EEG, and physical examination of extra cranial tissue, especially electron microscopy examination.