Objective: To observe the value of CT-guided localization of small pulmonary nodule with new pulmonary nodule locating needle before thoracoscopic surgery. Methods: Totally 50 patients with 53 small pulmonary nodules (diameter 5.0-15.0 mm) were retrospectively analyzed. All patients underwent video-assisted thoracoscopic surgery (VATS) after CT-guided localization. The positioning effect and complications were observed. Results: The anchor positioning needle was successfully implanted in 53 lesions of 50 patients, and the positioning success rate was 100% (53/53). During the puncture process, minor bleeding occurred near puncture needle passage in 9 cases (9/50, 18.00%), while mild pneumothorax and pleural reaction were noticed during the localization operation in 14 cases (14/50, 28.00%) and 1 case (1/50, 2.00%), respectively. VATS was performed on the day of positioning in 8 cases and on the next day of positioning in 42 cases. All 53 nodules were successfully found and removed according to the guidance of positioning needle. Conclusion: CT-guided localization of small pulmonary nodule with new pulmonary nodule locating needle before VATS was effective and safe.

The incidence of blood tumors is getting higher and higher. In addition to traditional chemoradiotherapy, in recent years, with the development of nuclear medicine technology and nuclide, nuclide therapy is playing an increasingly important role in the treatment of blood tumors. At present, the main research on the treatment of blood tumors focuses on acute myeloid leukemia (AML), but progress has also been made in other blood tumors. 213Bi and 225Ac-labeled monoclonal antibodies have achieved good results in blood tumors. 225Ac has overcome the short half-life of 213Bi and the problems of transportation and preservation. However, there are still many problems to be solved in the clinical use of α particles. This article reviews the progress of α-particle therapy in blood system, in order to provide a broader idea for the treatment of blood tumors.