Objective To study effects of hydrated rate on compressed deformation properties of natural articular cartilage.Methods The mass losses of pure cartilage,subchondral bone and cartilage sample were measured under different volatilization time with constant vacuum temperature container of 40 ℃,and confined compressed deformation of different hydrated rates was measured using UMT-2 multi-specimen test system.Combined with cartilage structural equation originated by Mow,the aggregated modulus and permeability of cartilage tissue were obtained.Results The mass losses of pure cartilage,subchondral bone and cartilage sample functioned with a non-linear ascending relation with volatilization time in the environmental temperature of 40 ℃.The volatilization time for different hydrated rates of 75%,50%,25%and 0% was 17 min,35 min,54 min and 100 min,respectively.Higher hydrated rate produced more compressed deformation,lower aggregated modulus and higher permeability.Conclusion The viscoelastic mechanisms of flow-dependence and flow-independence are manifested by compressed deformations while the aggregated modulus and permeability could quantitatively depict the mutual relation between hydrated rate and compressed deformation.

Objective:To investigate the correlation between stress hyperglycemia ratio (SHR) and poor outcome of successful recanalization after endovascular treatment in patients with acute ischemic stroke.Methods:From January 2019 to October 2022, patients with acute ischemic stroke received endovascular treatment and successful recanalization in the Second People’s Hospital of Lianyungang were included retrospectively. SHR was defined as the fasting blood sugar and glycosylated hemoglobin ratio. At 90 d after procedure, the outcome of patients was evaluated using the modified Rankin Scale score. 0-3 was defined as good outcome, and >3 was defined as poor outcome. Multivariate logistic regression analysis was used to determine the independent risk factor for poor outcome. Receiver operating characteristic (ROC) curve was used to evaluate the predictive value of SHR for 90 d poor outcome in patients with successful recanalization after endovascular treatment.Results:A total of 159 patients were enrolled, including 98 males (61.6%), aged 69.8±8.9 years old. The baseline National Institutes of Health Stroke Scale (NIHSS) score was 12.6±4.3, and SHR was 1.17±0.46. One hundred and five patients (66.0%) had good outcome, while 54 (34.0%) had poor outcome. There were statistically significant differences in SHR, fasting blood glucose, glycosylated hemoglobin, baseline NIHSS score and the proportion of patients with poor collateral circulation and symptomatic intracranial hemorrhage between the poor outcome group and the good outcome group (all P<0.05). Multivariate logistic regression analysis showed that SHR was an independent predictor of poor outcome (odds ratio 2.254, 95% confidence interval 1.136-4.278; P<0.001). The ROC curve analysis showed that the area under the curve of SHR for predicting poor outcome was 0.726 (95% confidence interval 0.648-0.804; P<0.001), which was higher than fasting blood glucose and glycosylated hemoglobin. The optimal cutoff value for SHR was 1.21, and the sensitivity and specificity for predicting poor outcomes were 66.23% and 75.82%, respectively. Conclusion:SHR is associated with the poor outcome of successful recanalization after endovascular treatment in patients with acute ischemic stroke and can be used as a potential predictor.