Objective:To explore the effects of deep venous thrombosis (DVT) prevention and control project on preventing DVT in inpatients of Vascular Surgery Department.Methods:In June 2018, the DVT prevention and control team formed in Vascular Surgery Department of Beijing Hospital investigated the cognition of medical staff in Vascular Surgery Department on thrombosis by electronic questionnaire and built the thrombosis prevention and control management system. The cognition of medical staff on thrombosis and incidence of thrombosis in inpatients was compared before (January 2018 to June 2018) and after (July 2018 to December 2018) implementing the project.Results:Before and after implementing the thrombosis prevention and control project, the utilization rate of Caprini assessment scale and was 79.27% (65/82) and 100.00% (82/82) respectively with a statistical difference ( P<0.001) ; the accuracy rate of DVT prevention was 90.24% (74/82) and 98.78% (81/82) also with a statistical difference ( P=0.016) ; the incidence of DVT of inpatients was 4.88% (4/82) and 0 (0/82) with a statistical difference ( P=0.043) ; the implement rate of thrombosis education was 76.67% (23/30) and 96.67% (29/30) with a statistical difference ( P=0.023) ; the compliance of DVT prevention of patients after discharge was 91.02% (71/78) and 98.68% (75/76) with a statistical difference ( P=0.032) ; the incidence of lower limb swelling was 1.28% (1/78) and 0 (0/76) with no statistical difference ( P=0.322) . Conclusions:Implementation of the DVT prevention and control project in Vascular Surgery Department can effectively improve cognition of medical staff and patients on DVT, and can reduce the incidence of DVT of inpatients in Vascular Surgery Department.

Objective:To investigate the expression levels of serum KLK5, IL-17 and IL-18 in patients with rosacea and their clinical significance.Methods:A prospective study included 65 patients with rosacea from the Department of Dermatology, Sichuan Provincial People＇s Hospital, from May to October 2022. There were 8 males and 57 females with an average age of (30.9±9.8) years, including 47 cases of erythematotelangiectatic type and 18 cases of papulopustular type. Twenty healthy individuals from the same hospital＇s physical examination during the same period were included as control group, consisting of 3 males and 17 females with an average age of (33.8±10.0) years. Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression levels of serum KLK5, IL-17, and IL-18. Investigator＇s global assessment (IGA) score was used to assess the severity of papules and pustules, and clinical erythema assessment (CEA) score was used to assess the severity of persistent erythema. The expression levels of serum KLK5, IL-17, and IL-18 were compared between the two groups, and the correlation between the severity of the disease and the expression levels of KLK5, IL-17, and IL-18 was analyzed. Additionally, the expression levels of KLK5, IL-17, and IL-18 in different subtypes of rosacea were compared.Results:The expression levels of serum KLK5, IL-17, and IL-18 in the rosacea group were (3134.01±448.82), (154.78±37.64), (236.24±38.81) pg/ml, respectively, all of which were higher than those in the healthy control group (2421.54±340.07), (95.36±24.94), (181.61±23.88) pg/ml, with statistically significant differences (all P<0.05). The levels of serum KLK5, IL-17, and IL-18 in patients with rosacea were positively correlated with IGA scores ( r=0.534, 0.767, 0.417) and CEA scores ( r=0.852, 0.459, 0.309) (all P<0.05). There were no statistically significant differences in the expression levels of serum KLK5, IL-17, and IL-18 between the erythematotelangiectatic and papulopustular subtypes of rosacea (all P>0.05). Conclusions:The expression levels of serum KLK5, IL-17 and IL-18 in patients with rosacea are higher than those in the healthy control group and are positively correlated with the severity of rosacea.