Objective:To explore the efficacy of local drainage in the treatment of paronychia caused by onyxis.Methods:From December 201 1 to December 2012,62 patients with paronychia caused by onyxis were treated by local drainage on onyxis.Re-sults:Patients were followed up for 6 months to 2 years.Among the 62 patients,58 patients were cured by once local drainage with 93.5% cure rate,and the other 4 patients were cured by secondary surgical treatment.There was no recurrence during the follow-up by June 2014.Conclusions:Local drainage on the onyxis for patients with paronychia caused by onyxis may achieve satisfactory efficacy.Meanwhile,adverse events as trauma and toenail deformation,which are caused by too large scope of operation or surgical methods which destroy nail bed or nail matrix,could be avoided.

Objective To investigate the effects of interleukin-18 ( IL-18 ) on M cells of intestinal mucosa in acute pancreatitis (AP) in rats. Methods Seventy SD rats were divided into seven groups: AP 6 hour group, 12 hour group, 24 hour group, IL-18 6 hour group, 12 hour group, 24 hour group, and control group at random. The models of AP were established. Serum, pancreatic tissue, and ileal mucosa were harvested. Serum amylase, glutamate pyruvate transaminse, total bilirubin, endotoxin, IL-27, and TNF-α were detected. Pathologic changes of pancreatic tissue and ileal mucosa were observed. The protein with reverse transcription-polymease chain reaction (RT-PCR). Results The level of serum TNF-α increased obviously in IL-18 6 hour group, 12 hour group, and AP group. The level of serum IL-27 increased in IL-18 6 hour group and AP group and back to normal in IL-18 24 hour group. The in IL-18 group than AP group (P < 0. 05 ). Conclusions IL-18 may affect M cells function and play important roles in intestinal barrier in acute pancreatitis.