1.Evaluation of the reliability of three different hepatitis E diagnosis reagents on the clinical acute hepatitis E.
Ying-jie ZHENG ; Qing-wu JIANG ; Jun ZHANG ; Qi ZHAO ; Sheng-xiang GE ; Mei-yang GAO ; Jian LIN ; Shang-hai OU ; Ning-shao XIA
Chinese Journal of Hepatology 2004;12(1):16-17
OBJECTIVETo evaluate the reliability of different hepatitis E diagnosis reagent tests on the acute hepatitis E.
METHODSThree acute hepatitis E diagnosis tests, E2-IgM (Wantai, China), GL-IgM and GL-IgG (Genelabs, Singapore) were compared for their reliability in a sera panel composed by 273 healthy individuals and 525 hepatitis.
RESULTSThe specificity of E2-IgM on the diagnosis of acute hepatitis E was 100.0%, it was significantly higher than GL-IgM (96.7%) and GL-IgG (85.4%). The sensitivity of E2-IgM and GL-IgG were 97.9% and 93.8% respectively, both significantly higher than GL-IgM (72.9%). Among 65 acute hepatitis cases being positive on GL-IgM test but negative on E2-IgM, 58 (89.2%) cases were found to be positive with anti-hepatitis A virus IgM, it indicated that the GL-IgM test might be interfered by other IgM antibodies on serum.
CONCLUSIONE2-IgM is a good test for the diagnosis of acute hepatitis E.
Acute Disease ; Hepatitis Antibodies ; blood ; Hepatitis E ; diagnosis ; Humans ; Immunoglobulin G ; blood ; Immunoglobulin M ; blood ; Reagent Kits, Diagnostic ; Sensitivity and Specificity
Result Analysis
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