Cerebral small vessel disease is a group of diseases mainly affecting intracranial small artery and arteriole.The main characteristic changes of cerebral small vessel disease on MRI are diffuse white matter hyperintensities,lacunar infarcts,cerebral microbleeds,and enlarged perivascular spaces.These changes may be correlated with cognitive impairment.At present,many scales are available and can be used to evaluate cerebral small vessel disease caused cognitive inpairment.

Newborn screening plays an important role in the 3-tiered system of prevention and control for birth defects in China.With the rapid development of newborn screening and diagnosis,quality control system including internal quality control and external quality assessment should be optimized and improved,and attention should be paid to pre-experimental quality control and management of positive patients as well.Widespread application of tandem mass spectrometry in newborn screening and diagnosis for inherited metabolic diseases greatly enhanced the detection capability and efficiency.The rapid development of molecular diagnosis techniques will confront new challenges and troubles.

OBJECTIVEResearch for establishing a risk monitoring theoretical model of high risk medical equipment at applying site.

METHODSRegard the applying site as a system which contains some sub-systems. Every sub-system consists of some risk estimating indicators. After quantizing of each indicator, the quantized values are multiplied with corresponding weight and then the products are accumulated. Hence, the risk estimating value of each subsystem is attained. Follow the calculating method, the risk estimating values of each sub-system are multiplied with corresponding weights and then the product is accumulated. The cumulative sum is the status indicator of the high risk medical equipment at applying site. The status indicator reflects the applying risk of the medical equipment at applying site.

RESULTEstablish a risk monitoring theoretical model of high risk medical equipment at applying site.

CONCLUSIONThe model can monitor the applying risk of high risk medical equipment at applying site dynamically and specially.

Medical equipment quality control is the core content of hospital management. It runs through the whole process of medical management, including the purchase, the installation and acceptance, the use and maintenance, the abandonment. The contents and measurements of the medical equipment quality control are introduced in the four processes. It can help hospitals carry out dynamic management for medical equipment quality control and set up a scientific and perfect quality control system.

Objective:Give a method for tracing boundary of inner-medium membrane in the ultrasonic image of common carotid artery.Methods: Giving a cost function before the programme begins to search the pixel point set whose cost function have the minimum value. The searching process starts from an initial anchor point given by the precedent programme. The calculation of cost function on each pixel point column on both sides of the initial anchor point will not stop until the terminal conditions are fulfilled. The programme will record the coordinates and pixel values of all the points with the minimum cost function value obtained from the calculation.Results: It can trace the boundary of inner-medium membrane in the CCA image from a clinical exam and can export the processed image with highlighted area. There is a daemon that records the coordinates and pixel values of the point set.Conclusion: This method can trace the boundary of inner-medium membrane in the CCA ultrasonic image when the CCA image is distinct.

OBJECTIVE: To study the pharmacokinetics and bioavailability of Ibuprofen Sustained Release Tablets in healthy volunteers.METHODS: A total of 18 male healthy volunteers were randomly divided into two groups.They were assigned to receive Ibuprofen Sustained Release Tablets(trial preparation) and Ibuprofen Sustained Release Capsules(reference preparation) respectively.The concentrations of ibuprofen in plasma were determined by RP-HPLC.The main pharmacokinetic parameters were obtained using 3p97 program.RESULTS: The Cmax of the two preparations were(25.43?0.78) ?g?mL-1 and(26.87?0.66)?g?mL-1 respectively;tmax were(3.67?0.52) h and(3.83?0.75) h;AUC0～24 were(181.20?5.12)?g?h?mL-1 and(187.58?5.29)?g?h?mL-1;AUC0～∞ were(184.34?5.35)、(191.19?4.87)?g?h?mL-1;MRT were(6.51?0.73)h and(6.80?0.48) h,respectively.The relative bioavailability of the sustained-release tablets was 103.7%.CONCLUSION: The ibuprofen sustained release tablets have remarkable sustained release efficacy.

Objective To explore the clinical characteristics,pathogens,inflammatory biomarkers,therapeutic methods and prognosis of necrotizing pneumonia (NP) in children.Methods The clinical data of children with NP who were admitted to the Department of Pediatrics of Shengjing Hospital of China Medical University from October 2010 to October 2015 were collected.The data included demographic data,laboratory test results,intrapulmonary complications,therapeutic methods and so on were analyzed,retrospectively.Results Forty-nine pediatric patients with NP were enrolled,31 cases were boys,18 cases were girls;the average age of the patients were 2.5 years (4 months-13 years).The average febrile time were (15.08 ± 5.92) d,and the hospital stay was (21.19 ± 10.83) d,respectively.The median value of peripheral blood leukocyte count was 17.7 × 109/L,the average of neutrophils ratio was (67.62 ± 18.52)％,and the median value of C-reactive protein (CRP) and procalcitonin (PCT) was 97.9 mg/L and 0.54 μg/L,respectively.Nineteen cases had Mycoplasma pneumoniae (MP) infection,16 cases with pneumonia chlamydia infection,9 cases complicated with MP and chlamydia pneumoniae infection,and 8 cases with positive bacterial culture,and 10 cases suffered from the intrapulmonary complications.Forty-seven cases got better prognosis with the treatment of antibiotics,glucocorticoids,intravenous immunoglobulin and other comprehensive therapeutic methods such as bronchoalveolar lavage with fiber bronchoscope and closed thoracic drainage.Conclusions NP is a severe complication of community-acquired pneumonia in children,and the occurrence of NP should be alerted in the children who have persistent high fever,higher inflammatory index and pleural effusion,but the great majority of patients do recover fully after comprehensive treatment.

0.05).However,the sex distribution was different between the two groups(P

OBJECTIVE:To improve the safety and effectiveness of total parenteral nutrition(TPN),and to provide reference for clinical rational use. METHODS:1400 TPN prescriptions in PIVAS from Jan. to Jun. 2013 were analyzed statistically in re-spects of rationality and stability. RESULTS:Among 1400 TPN prescriptions,there were 433 prescriptions of unreasonable glu-cose-lipid ratio(30.93%),782 prescriptions of unreasonable hot-nitrogen ratio(55.86%),443 prescriptions of unreasonable liquid amount(31.64%),1 261 prescriptions of unreasonable total calorie(90.07%)and 383 prescriptions of unreasonable treatment du-ration (27.36%). CONCLUSIONS:TPN prescription design is reasonable,but there are still some problems as low calorie,too high or too low hot nitrogen ratio,improper electrolyte dosage,improper duration of nutrition support. Clinicians should accurately assess the nutritional status of patients to design the prescriptions rationally and improve clinical safety and effectiveness of TPN. Pharmacists should further ensure the reasonableness of the prescription by prescription checking.

PurposeTo investigate the relationship between the TCD higher blood flow velocity and the pathology of internal cranial arteries,so as to improve the veracity of diagnosing cerebrovasculer diseases by TCD. MethodsComparing the blood flow velocity of 84 patients,whose cerebral blood flow are abnormal higher in one or above vessels detected by TCD,with the results of magnetic resonance angiography (MRA). ResultsCerebrovascular stricture,closeness and other diseases are discovered at different parts and to some extent in 80 of above 84 cases according to their detecting results of MRA. ConclusionIt is reliable to diagnose stricture,closeness and other diseases of internal cranial large arteries by TCD higher blood folw velocity.