OBJECTIVE: To study the pharmacokinetics and bioavailability of Ibuprofen Sustained Release Tablets in healthy volunteers.METHODS: A total of 18 male healthy volunteers were randomly divided into two groups.They were assigned to receive Ibuprofen Sustained Release Tablets(trial preparation) and Ibuprofen Sustained Release Capsules(reference preparation) respectively.The concentrations of ibuprofen in plasma were determined by RP-HPLC.The main pharmacokinetic parameters were obtained using 3p97 program.RESULTS: The Cmax of the two preparations were(25.43?0.78) ?g?mL-1 and(26.87?0.66)?g?mL-1 respectively;tmax were(3.67?0.52) h and(3.83?0.75) h;AUC0～24 were(181.20?5.12)?g?h?mL-1 and(187.58?5.29)?g?h?mL-1;AUC0～∞ were(184.34?5.35)、(191.19?4.87)?g?h?mL-1;MRT were(6.51?0.73)h and(6.80?0.48) h,respectively.The relative bioavailability of the sustained-release tablets was 103.7%.CONCLUSION: The ibuprofen sustained release tablets have remarkable sustained release efficacy.

OBJECTIVEResearch for establishing a risk monitoring theoretical model of high risk medical equipment at applying site.

METHODSRegard the applying site as a system which contains some sub-systems. Every sub-system consists of some risk estimating indicators. After quantizing of each indicator, the quantized values are multiplied with corresponding weight and then the products are accumulated. Hence, the risk estimating value of each subsystem is attained. Follow the calculating method, the risk estimating values of each sub-system are multiplied with corresponding weights and then the product is accumulated. The cumulative sum is the status indicator of the high risk medical equipment at applying site. The status indicator reflects the applying risk of the medical equipment at applying site.

RESULTEstablish a risk monitoring theoretical model of high risk medical equipment at applying site.

CONCLUSIONThe model can monitor the applying risk of high risk medical equipment at applying site dynamically and specially.

Medical equipment quality control is the core content of hospital management. It runs through the whole process of medical management, including the purchase, the installation and acceptance, the use and maintenance, the abandonment. The contents and measurements of the medical equipment quality control are introduced in the four processes. It can help hospitals carry out dynamic management for medical equipment quality control and set up a scientific and perfect quality control system.

Newborn screening plays an important role in the 3-tiered system of prevention and control for birth defects in China.With the rapid development of newborn screening and diagnosis,quality control system including internal quality control and external quality assessment should be optimized and improved,and attention should be paid to pre-experimental quality control and management of positive patients as well.Widespread application of tandem mass spectrometry in newborn screening and diagnosis for inherited metabolic diseases greatly enhanced the detection capability and efficiency.The rapid development of molecular diagnosis techniques will confront new challenges and troubles.

Cerebral small vessel disease is a group of diseases mainly affecting intracranial small artery and arteriole.The main characteristic changes of cerebral small vessel disease on MRI are diffuse white matter hyperintensities,lacunar infarcts,cerebral microbleeds,and enlarged perivascular spaces.These changes may be correlated with cognitive impairment.At present,many scales are available and can be used to evaluate cerebral small vessel disease caused cognitive inpairment.

Objective:Give a method for tracing boundary of inner-medium membrane in the ultrasonic image of common carotid artery.Methods: Giving a cost function before the programme begins to search the pixel point set whose cost function have the minimum value. The searching process starts from an initial anchor point given by the precedent programme. The calculation of cost function on each pixel point column on both sides of the initial anchor point will not stop until the terminal conditions are fulfilled. The programme will record the coordinates and pixel values of all the points with the minimum cost function value obtained from the calculation.Results: It can trace the boundary of inner-medium membrane in the CCA image from a clinical exam and can export the processed image with highlighted area. There is a daemon that records the coordinates and pixel values of the point set.Conclusion: This method can trace the boundary of inner-medium membrane in the CCA ultrasonic image when the CCA image is distinct.

0.05).There were obvious expression of PKC in ischemic preconditioning group,drug pretreatment+ ischemic preconditioning group and drug pretreatment group,but the rest groups not.Conclusion Shenyuandan was able to reduce the infarct size of myocardial ischemia in rats and had a pharmacological preconditioning-like myocardial protection,its mechanism may be related to PKC-mediated mechanism.

Objective To study the safety of laparoscopic cholecystectomy (LC) with low pressure pneumoperitoneum for high risk patients with gallstone. Methods 72 high risk patients with gallstones were undergone LC with low pressure pneumoperitoneum and their clinical data were analysed in our hospital during last three years. Results one of 72 patients was converted into open cholecystectomy due to bleeding, and two of them were converted due to severe adhesion. The others were performed successfully and no serious complications occurred. Conclusions LC is a safe method for high risk patients with gallstone. The key point is to use low pressure pneumoperitoneum during LC.

0.05).However,the sex distribution was different between the two groups(P

Objective Experimental study of the mechanism in esophageal restenosis after balloon dilation of benign stricture.Methods Esophageal stenosis model of the rats was created by 5ml of 50% NaOH solution burn with double balloon method, and esophageal restenosis (RS) model was developed by esophageal stenosis with dilation of PTCA balloon catheter. Quantitative and quanlitative analysis of esophageal stenosis and RS formation in the rats were observed and recorded by analytic measurements imaging and immunohistologic chemistry respectively. Results Esophageal benign stricture and RS model of 49 rats were developed. Cross section area and perimeter of esophageal mucosa layer, muscule layer and the whole layer had increased in experimental group. Comparing to control group, it had remarkable significance in statistics ( P