Objective To investigate the application value of contrast-enhanced ultrasound in the diagnosis of ovarian masses.Methods Ninety-four patients with ovarian masses were observed and undetermined by conventional ultrasound examinations who were underwent contrast-enhanced ultrasound examinations and were made the time-intensity curve.By analyzing the perfusion characteristics and the quantitative parameters of time-intensity curve,we compared the difference of different masses.Results The perfusion characteristics and the quantitative parameters of the time-intensity curve were different.The arrival time and the time to peak intensity of benign masses were later than those of malignant tumors.The peak iniensity of benign masses was lower than that of malignant tumors.There was a significant difference between the two groups.The arrival time and the time to peak intensity of benign tumors were later than those of malignant tumors.The peak intensity of benign tumors was lower than that of malignant tumors.There was a significant difference between the two groups.The time to peak intensity of non-tumorous lesions was later than that of malignant tumors.The peak intensity of non-tumorous lesions was lower than that of malignant tumors.There was a significant difference between the two groups.The arrival time of non-tumorous lesions was earlier than that of benign tumors.There was a significant difference between the two groups.Conclusion The perfusion characteristics and the quantitative parameters that draw from the time-intensity curve of different masses are different.Contrast-enhanced ultrasound is contributive to the diagnosis and the differential diagnosis of different masses.Contrast-enhanced ultrasound also has great clinical values to those ovarian masses whose ultrasonic appearance is complex and difficult to diagnose qualitatively.

Recent reports have indicated that Statins could remarkably improve the prognosis of patients suffered from coronary artery disease.And this effect is not only due to Statin's lipid-regulating function,but also correlated to its non-lipid-regulating action.Atorvastatin is the latest kind of statins.In this article,we specified the non-lipid-regulating effect of Atorvastatin in the prevention and therapy to coronary artery disease.Furthermore,we summarized its corresponding clinical evaluation or security.

Objective To investigate the expression and distribution of sialyl Lewis X in colorectal carcinoma and its relationship with carcinogenesis, progression and metastatic proclivity.Methods Microwave LSAB immunohistochemical technique was used to detect the expression of sialyl Lewis X in colorectal carcinoma and in normal mucosa. Immunoelectromicroscopic localization of sialyl Lewis X labelled by colloidal gold was also observed.Results The positive rate of sialyl Lewis X expression in primary colorectal cancer was 92 2%(83/90), and 16 7%(5/30) in normal mucosa. The positive rate was 100% in patients with lymphatic nodes metastasis, compared with that of negative nodes of 82 1% ( P

Objective To investigate the influence of Jianpi Bufei Huatan Recipe (JBHR), a Chinese herbal compound with the actions of strengthening spleen, tonifying lung and resolving phlegm, on the pulmonary function of childhood bronchial asthma at remission stage, and to explore the possible therapeutic mechanism. Methods Sixty bronchial asthma children at remission stage were divided into treatment group and control group, 30 cases in each group. Both groups were treated with inhalation of fluticasone propionate, and additionally, the treatment group was given oral use of JBHR(mainly composed of Radix Astragali, Radix Pseudostellariae, fried Rhizoma Atrctylodis Macrocephalae, Radix Saposhnikoviae, Poria, Pericarpium Citri Reticulatae, Rhizoma Pinelliae, prepared Radix Glycyrrhizae, calcined Os Draconis, calcined Concha Ostreae, and Semen Lepidii seu Descurainiae). The therapeutic effect of the two groups was evaluated after treatment, and the changes of peak expiratory flow(PEF), peak expiratory flow variation(PEFv) were also observed after treatment for 1, 2, 3, 6, 9, a nd 12 month(s). Results (1)The total effective rate of the treatment group was 93.33%, and that of the control group was 83.33%, the difference being significant(P<0.05). (2) During the treatment, PEF was higher and PEFv was lower in the treatment group than those in the control group(P<0.05). Conclusion JBHR could relieve the clinical symptoms, improve the pulmonary function and decrease the hyperactivity of airway of pediatric bronchial asthma at remission stage with lung-spleen qi deficiency.

Ankle brachial index(ABI),as a non-invasive and simple detection method,can be used to accurately assess and diagnose the severities and prognosis of the diabetic lower extremity arterial disease,cardiovascular and cerebral vascular diseases.

Objective　To investigate the level of cell adhesion molecule sialyl-LeX expression in colorectal carcinoma and its relation with carcinogenesis, differentiation, metastasis and prognosis. Methods　Sialyl-LeX expression and its optical density in colorectal carcinoma (n=90) and remote normal mucosa (n=30) were quantitatively studied with microwave-LSAB immunohistochemical method combined with image analysis technique. Fifty-three patients were followed up. Results　 The weaker staining in remote normal colorectal mucosa was observed in very limited parts of some deep crypts. Positive rate of sialyl-LeX expression was only 16.7%(5/30). The positive expression of sialyl-LeX was observed in 83 of 90 patients with colorectal carcinoma(92.2%). The apical cytoplasma of cancer tubules, the luminal contents, and the cytoplasma of the cancer cells were strongly stained. The mean integral optical density of sialyl-LeX positive cell in poorly differentiated adenocarcinoma was significantly higher than that in highly differentiated and mucinous ones (P<0.01). It was markedly higher in patients with positive lymphatic nodes than that in negative ones (P<0.01). With followed-up for longer than 5 years, it was much lower in the alive cases than that in the dead (P<0.01). Conclusion　These findings indicate that changes of sialyl-LeX expression and its optical density is related to carcinogenesis, differentiation, invasion and metastasis of colorectal carcinoma. It may be a good predicter for the prognosis of patients with colorectal carcinoma.

Objective To study the effect of Guipi Decoction on serum IL-1? and hippocampus IL-1RⅠ expression of depression model rats, and approach its mechanism of treating depression. Methods The depression model was established by received chronic unpredictable stress stimulus. Forty female Wistar rats were divided into four groups:control group, model group, saline group and Chinese medicine group. All rats were weighed and taken Open-field test on 0 and 22nd day, the serum IL-1? was detected with radio-immunity, and the expression of IL-1RⅠ was detected with immunohistochemical method. Result Compared with the control group, the weight, behavior points, serum IL-1?, expression of IL-1RⅠ of the model group and the saline group changed obviously while that in Chinese medicine group did not. Conclusion The anti-depressive mechanism of Guipi Decoction is related to maintaining the normal excretion of IL-1? and IL-1RⅠ expression from the chronic stress.

Objective To probe into the application of argon laser photo-coagulation (APC) in interventional endoscopic treatment of digestive diseases. Method 62 patients suffering from digestive diseases were treated with interventional endoscopic treatment with the aid of APC, including 393 cases of gastrointestinal polyps, 122 cases of gastritis verrucosa, 5 cases of Barrett's esophageal ulcer and 42 cases of hemorrhage of digestive tract. The effectiveness of the treatment was observed. Result For 350 cases of gastrointestinal polyp, in which the diameter of the polyp was less than 5 mm, the lesions were eliminated when checked by endoscopy 3 months after APC treatment, the curative ratio was 100%. For 43 cases of gastrointestinal polyps, in which the diameter of the polyp was larger than 5 mm, no residual lesions were found in 38 cases, and remarkable improvement was found in another 5 cases of Peutz-Jeghers syndrome. For 122 case of gastritis verrucosa, 116 cases recovered thoroughly, the curative ratio reached 95.1%. In 42 cases of hemorrhage of digestive tract, no hemorrhage was found in 41 cases after APC treatment. In 5 cases of Barrett′s esophageal ulcer treated with APC accompanied by PPIs, squamous cell epithelium was found to have recovered as shown by endoscopy and biopsy 3 months after the treatment, and no recurrence 12 months later. Conclusion APC can be widely used in digestive diseases including gastrointestinal polyps, hemorrhage of digestive tract, Barrett's syndrome, gastritis verrucosa, etc. APC has a special value for the treatment of gastrointestinal polyp when the diameter of the polyp was less than 5 mm, and also gastritis verrucosa.

Objective To develop a rapid and sensitive method for the determination of the percentage of blood chlormezanone by gas chromatograpy-mass spectrometry(GC/MS)for the clinical application on acute poisoning patients.Methods Chlormezanone in blood was extracted and separated with acetic ether.The acetic ether extractives from the blood were warmed with water at 80℃ and blown to dry with nitrogen gas.The dry extractives were then dissolved in 100?l of ethanol for GC/MS.To set up the linear equation for the determination of blood chlormezanone,draw the standard curve,calculate the extractive yield,detection limit and repeatability of chlormezanone.The GC was equipped with a 30m length,0.25mm I.D.,0.25?m film thickness HP-5MS(5% phenyl-methylpolysiloxane).Helium was used as the carrier gas at a constant flow rate of 1.0mL/min.The 1?l samples was injected GC/MS in split mode of 10∶1.The temperature program:160℃ for 2min,10℃/min up to 280℃ and hold for 10min.The injector,MS quadrupole rods,ion source and transfer line were kept at 250℃,150℃,230℃ and 280℃,respectively.The EI electron impact energy was 70eV.Results The extractive yield with acetic ether for blood chlormezanone was 82.1%,RSD=6.6%,implying that and acetic ether is an ideal extraction solvent.The calibration curve was y=13 852x+140 588,r=0.998 2.The detection limit was 4?g/L(SCAN m/z 30-280)and 0.1?g/L(SIM m/z 98,152,154).The RSD of precision in one day was 2.6%.The RSD of the precision between days was 4.9%.Conclusions The extraction and analysis method is suitable to the diagnosis of the acute poisoning patient of chlormezanone.

PURPOSE To investigate the effects of bcr3/abl2 anisense oligodeoxynucleotide (ASO) on chronic myeloid leukemia (CML). METHODS The effects of bcr3/abl2 ASO in 15 CML patients were evaluated by morphological observation, flow cytometer (FCM) techniques and DNA fragment measurement. RESULTS bcr3/abl2 ASO can induce apoptosis in CML. CONCLUSION Antisense techniques may provide a new way to cure CML.