Particular difficulties were presented when diagnosis of asthma in children under 5 was made. Diagnosis of asthma in early childhood is a big challenge and has been based largely on clinical justification and assessment of symptoms and physical signs. The PRACTALL consensus report focus exclusively on pediatric asthma, such as natural history and pathophysiology of pediatric asthma, different patterns of recurrent wheeze in pediatric patients, different phenotypes of asthma in children, and provides recommendations for diagnosis, practical management and monitoring. More factors should be considered for diagnosis of asthma in children under 5, including the patterns of recurrent wheeze, history of atopy, risk factor of asthma, long-term follow-up, extensive differential diagnoses, response to bronchodilator and/or anti-inflammatory treatment and so on.

This article is trying to find out the historical and realistic reasons of the restriction of the process of modernization of traditional Chinese medicine (TCM) from the history of TCM theory and practice of TCM institutional setup and related policies and many other aspects.Then it points out that the TCM in the background of the development of science and technology today is already has the necessary conditions of modernization,but the process can not be succeed overnight,it ought to be a systematic engineering.

Objective To study the effect of cooperative network on in-job training of nurses. Methods 80 randomly selected nurses with length of service from 1 to 5 years participated the written examination with alternation of the network test monthly. Self- designed questionnaires were sent out to survey the nurses about the recognition of the two testing modes. Department of Nursing compared and analyzed the exam results. Results The network test was popular among nurses, besides, it was economical, convenient, could save human resources, contribute to remarkable learning effect. Conclusions Application of cooperative network test in in-service training of nurses is convenient and practical, and can improve collaboration and team spirit of nurses.

Objective To study the impact of symptom score ,gastric emptying test and gastric accommodation of compound az-intamide(CA) combined with mosapride(MSP) drugs in patients with functional dyspepsia(FD) .Methods From February 2012 to March 2013 ,112 cases of hospital patients with FD were divided into the observation group (56 cases) and the control group (56 cases) .The control group was given MSP for treatment ,while the observation group was given MSP and CA .The curative effect , symptom scores and gastric accommodation ,as well as gastric emptying test results condition before and after treatment of two groups were Compared .Results The effective rate and the total effective rate of observation group were 51 .79% ,80 .36% ,which were significantly higher than the control group(32 .14% ,51 .79% )(P<0 .05) ;the improvement rate of the observation group was 8 .93% ,which was significantly lower than the control group 25 .00% (P<0 .05) .After treatment ,the observation group′s symp-tom score was (8 .7 ± 6 .3)points ,which was significantly lower than before treatment (22 .4 ± 7 .9)points ,and the control group af-ter treatment (12 .7 ± 3 .6) points ;the maximum amount of drinking water was (387 .1 ± 105 .8)mL ,which was significantly higher than the pre-treatment of (320 .8 ± 90 .9)mL ,and the control group after treatment of (351 .3 ± 77 .7)mL ;After treatment ,2 h full gastric emptying rate was 66 .07% (37/56) ,5 h full gastric emptying rate was 94 .64% (53/56) ,which were significantly higher than before treatment of 10 .71% (6/56) ,23 .21% (13/56) ,and the control group after treatment of 44 .64% (25/56) ,73 .21% (41/56) ,the differences were statistically significant (P<0 .05) .Conclusion CA combined MSP treat FD can significantly improve pa-tient symptoms ,promote gastric emptying ,and increase patients′gastric accommodation .The effect is significant and is worthy of recommendation .

Objective: To explore the therapeutic effect of Qishen Capsule (Radix Astragali, Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Notoginseng, Hirudo, etc.) for angina pectoris. Methods: 126 patients definitely diagnosed as suffering from angina pectoris were divided into two groups at random. The treatment group was given Qishen Capsules, 5 capsules each time, three times a day. The contol group was given Danshen Drop pills, 10 drop pills each time, three times a day. Both of the two groups went through one treatment course of 6 weeks. Results: In improving the clinical synptoms and myocardial ischemia, Qishen Capsule has the same effect as compared with Compoumd Danshen Drop pills but has better effect in lowering blood fat, blood viscosity and fibrinogen. Conclusion: Qishen Capsule is one of the effective medicines in treating againa pectoris

Objective To investigate the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and unexplained embryo arrest relationship.Methods By the method of gene chip analysis of MTHFR gene C677T polymorphism;select August 2014 and September 2015 in Zhoukou City Center Hospital infertility clinic unexplained Embryo arrest was more than or equal to 2 349 times pregnant women as the case group,and 421 without abortion history of health by women as the control group.The genotype and allele frequency distribution of embryo arrest and C677T MTHFR were compared between the experimental and control groups.Results MTHFR C677T genotype C/C in experimental and control groups were distributed with significant difference [P ＜ 0.001,x2 =70.484,OR =0.267,95％ CI (0.195 ～ 0.366)].Genotype C/T in experimental and control groups was distributed without significant difference [P =0.714,x2 =0.156,OR =1.06,95％ CI (0.795 ～ 1.412)].T/T genotype in experimental and control groups was distributed with significant difference [P ＜ 0.001,x2 =98.812,OR =7.961,95％ CI (5.055 ～ 12.537)].C allele in experimental and control groups was distributed with significant difference [P ＜0.001,x2 =13.287,OR =0.291,95％ CI (0.236 ～0.361)].Allele t in experimental and control group was distributed with significant difference [P ＜0.001,x2 =13.287,OR =3.431,95％ CI (2.772 ～4.246)].Conclusions Embryo arrest was not associated with C677T gene mutations in MTHFR gene,and the high expression of T/T gene might be a risk factor for women of childbearing age.

Objective To investigate follow-up willingness of patients and their families after discharge.Method A follow-up willingness questionnaire for cancer patients and their families was designed,the items covering follow-up willingness,follow-up methods, follow-up time,follow-up demand for content etc.Results Ninety-three point nine percent of patients and 96.9%of families were willing to accept follow-ups;84.8%of patients and 81.3%of families were willing to accept follow-ups by phone calls;42.4%of patients and 43.8%of families were willing to take follow-ups at any time,33.4%of patients and 40.7%of families would like the follow-up in the afternoon or evening.69.7%of patients and 62.4%of families would like the follow-ups of 5 to 10 minutes. 97.0%of patients and 93.8%of families were willing to take the phone call follow-ups by physicians and 33.3%of the patients,31.2%of their families by nurses.In terms of contents,the patients and families were willing to have the medication instructions,re-examination reminder,appointments for hospitalization,dietary guidance,health counseling,exercise guidance,psychological counseling and nursing on complications and PICC.There was a high consistence on follow-up contents after discharge in cancer patients and their families(all P>0.05).Conclusion The hospitalized cancer patients and their families are willing to take telephone follow-up after discharge by the hospital staff,but most choose to have follow-ups by a doctor.The follow-up contents are multifaceted.

Objective To observe the clinical efficacy of acupuncture at phenomaxillary ganglia in treating dry eye syndrome (DES). Methods Totally 148 DES patients were randomized into a treatment group of 72 cases and a control group of 76 cases. The treatment group was intervened by acupuncture at phenomaxillary ganglia plus Jingming (BL 1), Sibai (ST 2), and Taiyang (EX-HN 5), while the control group was by using eye drops of artificial tears. The DES symptoms score and Visual Analogue Scale (VAS) were observed before and after intervention, and the clinical efficacies were compared. Results The total effective rate was 90.3%in the treatment group versus 68.4%in the control group, and the difference was statistically significant (P<0.01). The DES and VAS scores were significantly changed after intervention in both groups (P<0.01). The changes of DES and VAS scores in the treatment group after intervention were significantly different from those in the control group (P<0.05). Conclusions Acupuncture at phenomaxillary ganglia can go deep and directly reach the affected area, and thus is an effective method in treating DES.

Objective To study the frequency of CYP2C19 genotype and allele mutation of cytochrome P450 in the southeast part of Henan province,and to understand the effect of sex,age,body mass index (BMI)on the genetic polymorphism of CYP2C19.Methods Genetic polymorphism analysis of CYP2C19 gene in 161 healthy people in Henan province,using gene chip method,87 male,74 female,aged 26 -82 years old,and BMI 17 -31. Results The experiment,a total of CYP2C19 six different gene mutation type,CYP2C19 1 of (40.4%),CYP2C19*1 /*2 (39.1%),CYP2C19 *2 /*2 (14.9%),CYP2C19 *1 /*3 (3.1%),CYP2C19 *2 /*3 (2.5%), CYP2C19*3 /*3 (0%);allelomorph CYP2C19 * 2 (35.7%),follow (2.8%).87 male wild type homozygous for CYP2C19 1 of (39.1%),allelomorph CYP2C19 * 2 (39.1%),follow (3.1%),74 female wild type homozygous for CYP2C19 1 of (41.9%),and other allelomorph CYP2C19 * 2 (32.3%),follow (2.5%).103 cases were more than or equal to 58 years old wild type homozygous for CYP2C19 1 of (47.6%),allelomorph CYP2C19 * 2 (39.8%),follow (3.7%),58 <58 years old wild type homozygous for CYP2C19 1 of (27.6%),and other allelo-morph CYP2C19 * 2 (31.7%),follow (1.9%).BMI >25 groups of wild -type homozygous for CYP2C19 1 of (37.7%),allelomorph CYP2C19 * 2 (32.9%),follow (1.2%),BMI <25 groups of wild -type homozygous for CYP2C19 1 of (42.4%),and other allelomorph CYP2C19 * 2 (38.5%),follow (4.3%).Conclusion There was no significant difference in the genotype of CYP2C19*2 between the BMI and *3 in the southeast part of Henan province.

Invasion aud metastasis are the major biological characteristics of malignant tumors.The studies in past decades showed that lymphangiogenesis was closely related to cancer metastasis.The metastasis of tumor is a complex pathological process which involved in multiple genes and protein factors.This review discussed the structure and physiological characteristics of the lymphatic system,elaborated the factors in lymphangiogenesis,the relationship of metastasis and lymphangiogenesis,and major mechanism of tumor metastasis through lymphatic vessels.