OBJECTIVE: To evaluate the relationship between human papilloma virus (HPV) infection and the occurrence, recurrence and malignant transformation of nasal inverted papilloma (NIP). METHOD: With comprehensive retrieval of related literature that had been published in databases included Pubmed (1990--2011), Cochrane Library, CNKI (1979-2011), VIP (1989-2011), CBM (1990-2011) and WANFANG Meta-analysis software Rev-Man 5.0 was used to analyze the raw data and to calculate the value of combined odd ratio (OR) and 95% confidence interval (CI). RESULT: According to Meta-analysis, the occurrence group between HPV and NIP, the OR was 34.44 and 95% CI was 12.96-91.56; the recurrence group, the OR was 3.66 and 95% CI was 1.77-7.56, to the high-risk HPV, the OR was 1.94 and 95% CI was 0.30-12.58; the malignant transformation group, the OR was 1.79 and 95% CI was 0.94-3.40 to the high-risk HPV, the OR was 49.35 and 95% (CI was 0.45-11.23. CONCLUSION HPV may play an important role in the occurrence and recurrence of NIP and high-risk HPV was closely related to the progress of NIP.
DNA, Viral ; Humans ; Nose Neoplasms ; virology ; Papilloma, Inverted ; virology ; Papillomaviridae ; Papillomavirus Infections ; pathology

Objective To understand the status quo of knowledge , attitude and behavior on fall prevention among stroke patients , so as to provide the basis for targeted prevention education .Methods Totals of 96 stroke patients were recruited and investigated with self-designed questionnaire on their knowledge , attitude and behavior for falls prevention .Results Ninety-six questionnaires were issued and all were returned with a effective responsive rate of 100%.The score of fall prevention attitude and confidence was ( 4.11 ±0.73 ) , which was higher than the score of falls prevention knowledge ( 3.70 ±0.71 ) and behavior ( 3.07 ±0.74 ) . Knowledge and behavior scores of female patients were significantly higher than that of male patients [ ( 4.24 ± 0.68) vs (3.05 ±0.24), (3.37 ±0.58) vs (2.16 ±0.31), t=7.961,6.984, respectively;P<0.01].The knowledge, attitude and behavior scores of stroke patients with less than 70 years old respectively were (3.94 ± 0.32),(3.67 ±0.35)and(1.93 ±0.57), and that of stroke patients with over 70 years old were (3.04 ± 0.81 ) , ( 4.35 ±0.73 ) , and ( 3.89 ±0.67 ) , and the differences were statistically significant ( t =2.478 , 2.146 ,4.951;P<0.05 ) .The knowledge , attitude and behavior scores of patients without bachelor's degrees respectively were (3.77 ±0.43),(3.99 ±0.33) and (3.46 ±0.62), and that of patients with bachelor's degrees respectively were (4.23 ±0.43),(3.45 ±0.32) and (2.78 ±0.56), and significantly differences were found between them ( t =2.783 , 1.721 , 2.432;P <0.05 ) .Conclusions Development of targeted education on falls prevention is necessary for stroke patients , and different education degree and situation of patients should be considered .

Objective To observe value of 0D-1D coupling model and 3D fluid-structure interaction(FSI)model based on coronary CT angiography(CCTA)for displaying hemodynamic characteristics of coronary artery stenosis.Methods Based on CCTA data of the stenosed left anterior descending branch(LAD)in a patient with coronary heart disease,an 0D-1D coupling model and 3D FSI model were built,respectively.Then hemodynamic characteristic indexes,including the pressure,flow velocity and wall shear stress(WSS)were obtained in every 0.01 s during 1 s at 5 sampling points(i.e.sampling point 1-5)using these 2 models,respectively,and the consistencies of the results between models were evaluated with Spearman correlation coefficient rs.Results The time consuming for construction of 0D-1D coupling model and 3D FSI model was 0.033 min and 704 min,respectively.Both models showed basically distribution of the pressure,flow velocity and WSS of the stenosed LAD.For more details,the pressure at the stenosed segment of LAD and the proximal segment of stenosis were both higher,which gradually decreased at the distal segment of stenosis,and the flow velocity at the proximal segment of stenosis was in a relatively slow and uniform condition,with significantly increased flow velocity and WSS at the stenosed segment.Compared with 3D FSI model,0D-1D vascular coupling model was relatively unrefined and lack of distal flow lines when displaying blood flow velocity.For sampling point 2 at the stenosed segment of LAD,no significant consistency for pressure between 2 models was found(P=0.118),but strong consistency for the flow velocity and WSS(rs=0.730,0.807,both P＜0.05).The consistencies of pressure,flow velocity and WSS between 2 models at the proximal and distal segment of stenosis,i.e.1,3-5 sampling points were week to moderate(rs=0.237-0.669,all P＜0.05).Conclusion 0D-1D coupling model exhibited outstanding computational efficiency and might provide relatively reasonable results,while 3D FSI model showed higher accuracy for details and streamline when simulating LAD stenosis.

Objective To assess the effects of action research on preventing perioperative deep venous thrombosis ( DVT ) form in patients with intracerebral hemorrhage. Methods We selected 93 cases of intracerebral hemorrhage in Neurosurgery of our hospital from 2011 to 2014. A total of 45 cases, who hospitalized from 2011 to 2012, were selected as control group and received routine nursing and perioperative routine nursing, while 48 cases, who hospitalized from 2013 to 2014, were chosen as treatment group and received action research to intervened legs exercise with four steps including plan, action, observation and reflection based on nursing of control group. Then after four steps spiral cycle, we made the plan of lower extremities excise and implemented. The incidences of DVT and rehaemorrhagia in two groups were observed. Results The rate of DVT and rehaemorrhagia were 0 in the treatment group, which were significantly lower than 13. 33% (6/45) and 4. 44% (2/45) respectively in the control group (P<0. 05). The coagulation index changes had no significantly difference between two groups. The difference of DVT had statistical significance between two groups (P<0. 01), but the difference of rehaemorrhagia had no statistical significance between two groups (P>0. 05). Conclusions Action research method is applied for plan of perioperative lower extremities excise in patients with intracerebral hemorrhage, which can decline the incidence of DVT.

Objective:To investigate the clinical application value of peripheral blood metagenomic next-generation sequencing (mNGS) test for patients with hematological diseases accompanied by fever.Methods:The blood mNGS results and clinical data of inpatients with hematological diseases accompanied by fever treated in the Hematology Department of Tianjin Medical University General Hospital in March 2020 to June 2021were retrospectively analyzed. A total of 90 patients with 98 cases of specimens were included. The pathogen distribution characteristics and mNGS test performance were analyzed.Results:The positive rate of peripheral blood mNGS was significantly higher than that of traditional examination (68.37% vs 37.76%, P<0.001) and blood culture (68.37% vs 9.18%, P<0.001) . Viral, bacterial, and fungal infections accounted for 38.81%, 14.93%, and 2.99% in patients with single-pathogen infections, respectively. Polymicrobial infections accounted for 43.28%, in which viral and bacterial coinfections were the most common type (25.37%) . There were 55 virus-positive cases (82.09%) , 30 bacteria-positive cases (44.78%) , and 14 fungus-positive cases (20.90%) . The clinical approval rate of peripheral blood mNGS was 64.63% (63/98) . The sensitivity, specificity, positive predictive value, and negative predictive value (NPV) of peripheral blood mNGS were 75.68%, 36.07%, 41.79%, and 70.97%, respectively, and the overall consistency rate with traditional examination was 51.02%. Of the 22 pulmonary infection cases with no detectable pathogens by conventional tests, the pathogens were identified by peripheral blood mNGS in 14 cases, 10 of which were clinically approved. Conclusion:The positive rate of peripheral blood mNGS was significantly higher than that of blood culture and traditional laboratory examination. Peripheral blood mNGS had a high clinical recognition rate, sensitivity, and NPV in the detection of pathogens in patients with hematological diseases accompanied by fever.