BACKGROUND:Physical structure and inorganic composition of composite calcium phosphate bone implants are similar to human bone, and the implants have good bioabsorbable ability and biocompatibility. Studies have confirmed that Dipsacus powder can significantly improve the speed of bone defect repair.
OBJECTIVE:To study the effects of Dipsacus asperoides/composite calsium phosphate bone implant material in the repair of bone defects.
METHODS:Bone defects of 1.0 cm×0.5 cm×0.3 cm were made on the bilateral mandibular bodies. The right side was implanted with Dipsacus asperoides/composite calsium phosphate bone implant as experimental group and the left side implanted with calcium phosphate bone material served as control group. Samples were col ected at 4, 8, 12 weeks after implantation for gross observation, cone beam CT, scanning electron microscope observation and histological observation.
RESULTS AND CONCLUSION:(1) Gross observation:the osteogenic speed, degradation rate and hardness in the experimental group were higher than those in the control group. (2) Cone beam CT detection:the implant in the experimental group was more tightly integrated with the surrounding tissues than that in the control group, and the degradation speed in the experimental group was higher than that in the control group. (3) Scanning electron microscope observation:there were many fibrous connective tissues between the implants and the surrounding tissues in the two groups, which was more obvious in the experimental group than the control group. With time gone, the implants were combined with the surrounding tissues more tightly. (4) Histological observation:the osteogenic speed and activity in the experimental group were superior to those in the control group. These findings indicate that Dipsacus asperoides combined with composite calcium phosphate bone implant can accelerate bone repair.

Objective:To compare the effects of different exercise modes on inflammation, endothelium functioning and the ambulatory blood pressure (ABP) of middle-aged hypertensive patients, so as to provide a basis for optimizing rehabilitation training prescriptions.Methods:Ninety persons with hypertension were randomly divided into an aerobic exercise group, a resistance training group and a control group, each of 30. All maintained their routine daily living habits and medications. In addition, the aerobic exercise group performed aerobic exercise, while the resistance training group took resistance exercise for twelve weeks. Inflammatory response, endothelium functioning and 24-hour ABP were evaluated before and after the experiment.Results:The subjects tolerated the different exercises well. After the experiment, the daytime systolic blood pressure (SBP) and 24-hour SBP of those in both exercise groups had decreased significantly, on average. Flow-mediated dilation had increased significantly. The average plasma nitric oxide and interleukin-10 levels had increased significantly, and the average C-reactive protein, monocyte chemoattractant protein-1, vascular cell adhesion molecule-1, lectin-like oxidized LDL receptor-1, and endothelin-1 levels had decreased significantly in the aerobic exercise group, but not in the control group.Conclusions:Both regular aerobic exercise and resistance training benefit blood pressure control and reduce the risk of cardiovascular disease, at least among middle-aged persons with hypertension. Aerobic exercise tends to have the better effect.