Along with contemporary development of life support technology in perinatology and neo-natal intensive care,mortality of preterm infants has been reduced.However,the problems caused by the brain damage have been attracting more and more attention.The long-term outcome of prematures depends on their nervous system sequelae among the total complications.Preterm infants'brain damage mainly includes intravent-ricular hemorrhage(IVH)and periventricular leukomalacia(PVL).IVH and its complications are the main causes of early death,mental and physical developmental disorder of neonatals.Thus,the early diagnosis of brain dam-age,especially PVL,has become a serious problem that we are going to face.The scholars in or aboard hao payed close attention to these markers,such as MBP、S100B、ACT A、NF-L、NGB、MMP、IL-6、IL-10、IL-1 1 、NSE.The paper reviews these biological markers.

Objective By analyzing academic publications written by young doctors in a University Affiliated Hospital during 2013-2015,todescribe the characteristics and rules,and analyze the influencing factors,and to build a basis for providing better service and making effective incentive policies.Methods Materials were collected from questionnaire survey and administrative departments,SPSS software was used to analyze the relationship between factors and the numbers of academic papers.Results 214 young doctors published 486 papers in 2013-2015.Results show that people with senior titles and supervise the graduate students,as the PIs of research projects,as a research team PI,fixed time for research,belonging to mature science research team,interdisciplinary cooperation,cooperation with other units,would be able to have more publications.Conclusions Management staffs should know that research fund is important to young doctors to start and follow-up their research work;they Should help the research team to develop and mature,should help young doctors to find and integrate into the research team;ensure young doctors have fixed research time by making policy,should help young doctors to form the good habit of research;Strengthen cross disciplinary construction,help young doctors to carry out inter unit and inter professional collaboration.

OBJECTIVETo observe the effects of Rubiae Radix et Rhizoma (RRR) and carbonized Rubiae Radix et Rhizoma (CRRR) on the acute blood stasis rat model, and reveal their differences in efficacy.

METHODThe acute blood stasis model was induced by subcutaneously injecting adrenaline hydrochloride and soaking in ice water. Yunnan Baiyao was used as the positive control drug, and administered for consecutively seven days. This model was adopted to observe the effect of high, middle and low dose RRR and CRRR groups on hemorheology, thrombin activity, and blood platelet system.

RESULTRRR could significantly reduce the wholeblood viscosity and plasma viscosity of blood stasis rats under different shear rates, and showed certain two-way regulating function in hemostasis. It also showed certain effect on ADP-induced platelet aggregation rate, but which was lower than CRRR. CRRR achieved the main hemostatic mechanism by stimulating intrinsic and extrinsic blood coagulation and fibrinogen, and could significantly enhance the platelet aggregation rate of rats in the acute blood stasis model (P <0. 01).

CONCLUSIONRRR had the effect of removing blood stasis and hemostasis, while CRRR mainly has the hemostatic effect. This further demonstrates the traditional processing theory of "promoting blood circulation with crude herbs and stopping bleeding with processed herbs".

6-Ketoprostaglandin F1 alpha ; blood ; Animals ; Blood Coagulation ; drug effects ; Carbon ; chemistry ; Chemistry, Pharmaceutical ; methods ; Disease Models, Animal ; Drugs, Chinese Herbal ; chemistry ; pharmacology ; Female ; Hemodynamics ; drug effects ; Male ; Medicine, Chinese Traditional ; methods ; Rats ; Rats, Sprague-Dawley ; Rubia ; chemistry ; Thromboxane B2 ; blood

Objective To understand the change of hydrological regime in the Yangtze River and schistosomiasis endemic situation after the implementation of Three Gorges Project in Hubei Province. Methods The data of hydrological regime of the Yangtze River,schistosomiasis epidemic situation,and Oncomelania hupensis snail status were collected and analyzed in Hu-bei Province from 2002 to 2012. Results After the implementation of the Three Gorges Project in 2003,the water level of the Yangtze River slightly rose from January to March,the average water level in May and August both reduced compared with that in 2002,and the time of water withdrawal was moved up. The endemic situation of schistosomiasis showed a decline tendency in areas along the Yangtze River in Hubei Province. The positive rate of serological tests in the residents and the Schistosoma ja-ponicum infection rate in bovine decreased by 2.97%and 92.64%respectively. The numbers of human and bovine infected with S. japonicum decreased by 48.35%and 94.48%,respectively. Conclusion After the implementation of the Three Gorges Proj-ect,the schistosomiasis endemic situation shows a decline tendency in the areas along the Yangtze River in Hubei Province ,but the long-term monitoring still need to be carried out.

Objective To study the endemic trend of schistosomiasis japonica in Hubei Province,so as to provide the theo?retical basis for surveillance and forecasting of schistosomiasis. Methods The time?series auto regression integrated moving av?erage(ARIMA)model was applied to fit the infection rate of residents of Hubei Province from 1987 to 2013,and to predict the shot?term trend of infection rate. Results The actual values of infection rate of residents were all in the 95%confidence inter?nals of value predicted by the ARIMA model. The prediction showed that the infection rate of residents of Hubei Province would continue to decrease slowly. Conclusion The time?series ARIMA model has good prediction accuracy,and could be used for the short?term forecasting of schistosomiasis.

Objective To understand the dynamic schistosomiasis situation in Hubei Province so as to provide the evidence for formulating the effective control strategy. Methods According to the Scheme of Schistosomiasis Surveillance in Hubei Province the 2009 edition 207 endemic villages were selected and investigated for the schistosome infections of residents and livestock and the distribution of Oncomelania hupensis snails. Results The average infection rates of residents and cattle were 0.35% and 0.15% respectively and the endemic situation of fishermen and farmers were relatively serious 0.44% and 0.42% respectively . The density of living snails was 0.30 snail/0.1m2 but no infected snails were found. Conclusion The en-demic situation of schistosomiasis in Hubei Province was stable in 2013 but the efforts for the infectious source control still should be strengthened.

Objective To evaluate the value of serum E2 levels during COH in predicting IVF-ET outcome. Method Data from 311 IVF-ET cycles received long protocol were collected and analyzed according to E 2 levels 5 days after stimulation:Group A (E2≤500 pmol/L), Group B (500 2 000 pmol/L). Results In groups with E2>1 000 pmol/L, the conditions of oocyte and embryo are higher than E2<1 000 pmol/L. With the increase of E2 levels, period cancellation rate increases. When E2> 2 000 pmol/L, the pregnancy rate become lowest. Conclusion E2 levels among 1 000~1 500 pmol/L during early COH predicts a better pregnancy outcome.

Objective To analyze the surveillance results of schistosomiasis and understand the transmission situation in Hu?bei Province in 2014. Methods According to the Scheme of Schistosomiasis Surveillance in Hubei Province(the 2009 edi?tion),207 endemic sites were selected,where the schistosome infections of residents and livestock,and the distribution of On?comelania hupensis snails were investigated. Results In the 207 sites,there were 27 sites without positive results of the blood tests and 129 sites without positive results of the stool tests. The infection rates of residents and cattle were 0.17%and 0,respec?tively. The density of living snails was 0.339 3 snails/0.1m2,the rate of living snails was 10.12%,and the infection rate of snails was 0. The infection rate of residents in the inner embankment type was 0.22%,higher than the rates in the other types. In differ?ent age groups,the infection rate in the 50-59 years age group was higher than the rates in other age groups. The infection rates of residents in farmer and fisherman were higher than those in the other occupation groups. The infection rate of floating people was 0,and no acute schistosomiasis patients were found. Conclusion The endemic situation of schistosomiasis has decreased obviously in Hubei Province,and the whole province has achieved the criteria for transmission control of schistosomiasis.

Objective To grasp the distribution and epidemiology of confirmed cases of schistosomiasis in Hubei Province, so as to provide the evidence for promoting the prevention and control work. Methods The confirmed cases of schistosomiasis in Hubei Province from 2010 to 2014 were epidemiologically investigated,and the prevalence characteristics and main influenc?ing factors were analyzed. Results A total of 10 102 confirmed cases from 2010 to 2014 were surveyed. There were 1 062 local infected patients,accounting for 10.51%and including 354 repeated infections and 17 newly infected. There were 290 foreign?infected patients,accounting for 2.87%,with 206 repeated infection cases and 84 newly infected. There were 8 750 historical patients,including 2 229 patients who leaked the former schistosomiasis investigations,accounting for 22.06%;570 patients missed treatment,accounting for 5.64%;3 640 patients were treated with non?standard therapy,accounting for 36.03%;2 311 patients were treated with poor medication efficacy,accounting for 22.88%. The multivariate non?conditional Logistic regres?sion,targeting at confirmed cases in 2014,showed that,for the leaking investigations,the potential risk factors included the age,educational level,and latrine renovation(b>0,OR>1),the protective factors were the times of previous treatment,cat?tle feeding in villager team,and Oncomelania hupensis snails in surroundings(b<0,OR<1);for the treatment?missing,the age,educational level,snails in the surroundings of residence were risk factors(b<0,OR<1);for the substandard treat?ment,the risk factors included the occupation and snails in the surroundings of residence(b>0,OR>1),and the educational level and snails in the own field were protective factors(b<0,OR<1). Conclusion The epidemiological investigation on the confirmed cases of schistosomiasis could grasp the epidemic factors so as to improve the management and carry out the scientific control.

Objective To investigate the expression of Foxp3~+ lymphocytes in breast carcinoma tissues and their correlation with other pathological factors,and to investigate the mechanism of action of Treg cells.Methods The expression of Foxp3~+ lymphocytes in the breast cancer tissue and non-cancerous tissue was detected by flow cytometry (FCM) in 30 breast carcinoma patients, and its correlation with other pathological factors was statistically analyzed by multiple linear regression analysis.The expression of TGF-β and IL-10 in the lymphocytes infiltrated in breast cancer tissue and non-cancerous tissue was measured by immunohistochemistry, and their correlation with the expression of Foxp3~+ lymphocytes was statistically analyzed by linear correlation dependability analysis. Results There was significant difference in the expression of Foxp3~+ lymphocytes between the malignant and non-cancerous breast tissues(P<0.05),and it was positively correlated with the clinical stage,blood vessel invasion and the matter of axillary lymph node metastasis(P<0.05). The expression of IL-10 in the tumor infiltrating lymphocytes was positively correlated with the expression of Foxp3~+ lymphocytes(P<0.05).Conclusion The expression level of Foxp3~+ lymphocytes is correlated with invasion and metastasis of breast carcinoma, and the IL-10 secreted by Foxp3~+ lymphocytes may be involved in this effect.Foxp3~+ lymphocytes can be used as an assistant marker for prediction and new therpeutic target of breast cancer.