Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Neoplastic Stem Cells ; Pyrazoles ; Pyrimidines

Antineoplastic Agents ; pharmacology ; therapeutic use ; Benzamides ; Clinical Trials, Phase II as Topic ; Drug Resistance, Neoplasm ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; drug therapy ; Piperazines ; pharmacology ; therapeutic use ; Pyrimidines ; pharmacology ; therapeutic use

Molecular Epidemiology ; trends

?AlM:To explore the use of rigid gas permeable ( RGP ) contact lens, and its clinical effect and safety in the treatment of adult high and special type ametropia.
? METHODS: Totally 110 cases ( 185 eyes ) of Ophthalmology Center fitting of RGP from January 2010 to December 2012 were retrospective analyzed. According to the refractive error types, patients were divided into high myopia astigmatism group( 49 cases, 92 eyes), 36 cases (64 eyes) of keratoconus group, special ametropia group (25 cases, 29 eyes). Corrected visual acuity differences, adverse reactions of different temporal acuity and conventional frame in the three group were observed after wearing RGP.
?RESULTS:After wearred RGP, corrected visual acuity of high myopic astigmatism group was 4. 94 ± 0. 16, keratoconus group was 4. 98±0. 15, and special ametropia group was 4. 87±0. 19; they were significantly better than wearing frame mirror 4. 86±0. 23, 4. 79±0. 22, 4. 61±0. 27 and the differences were statistically significant (P<0. 05). After 3 and 6mo of wearing RGP, patients eyesight after RGP was better than that of wearing frame glasses ( P<0. 05 ) . As the astigmatism group, keratoconus group, special ametropia group wearing RGP, visual acuity after distribution were obviously better than the case when wearing frame glasses(P<0. 05).
?CONCLUSlON: Wearring RGP can correct adult high and special type ametropia than ordinary frame glasses, which avoid the occurence of dry eye, foreign body sensation, and easy fatigue. lt is worthy of clinical application.

Objective:To observe the effect of point-toward-point needling at points on the low back regions on residual back pain after percutaneous kyphoplasty (PKP),thoracolumbar function and quality of life (QOL) in patients with osteoporotic vertebral compression fracture (OVCF).Methods:A total of 72 patients with OVCF and residual back pain after PKP were included and allocated into a treatment group (n=36) and a control group (n=36) by the random number table.Cases in the control group received salmon calcitonin injection (miacalcic),for 1 mL each time,once a day,and oral intake of calcium carbonate D3 pill,600 mg each time,once a day,whereas cases in the treatment group received point-toward-point needling at points on the low back regions and electroacupuncture (EA) for 30 min each time,once a day and 6 times a week on the basis of the treatment in the control group.Treatment in both groups lasted for 2 weeks.Therapeutic efficacy indicators including visual analog scale (VAS),Oswestry disability index (ODI) and Barthel index (BI) were evaluated before and after treatment and at follow-up visit (1 month after treatment).Results:The total effective rate was 94.4％ and 88.9％ in the treatment group after treatment and at the follow-up visit,respectively,higher than 77.8％ and 69.4％ in the control group,and the between-group differences were statistically significant (both P＜0.05).After treatment and at the follow-up visit,the VAS and ODI scores decreased,and BI scores increased in both groups,and the intra-group differences were statistically significant (all P＜0.05).After treatment and at the follow-up visit,between-group differences of VAS,ODI and BI scores were statistically significant (all P＜0.05).Conclusion:On the basis of conventional medication treatment,point-toward-point needling at points on the low back regions has a good therapeutic effect in relieving residual back pain after PKP,improving thoracolumbar function and QOL,better than conventional medication treatment alone.

Objective: To analyze the effect between minimally invasive percutaneous plate fixation and open reduction internal fixation on patients with Tibial shaft fracture. Methods:Chosen patients with tibial shaft fracture as research subjects, randomly divided observed groups receiving minimally invasive percutaneous plate fixation and control group receiving open reduction internal fixation, detecing surgery-related indicators, AKSS knee score and adverse conditions incidence. Results:1)After surgery, surgery time and total hospital stay of observation group patients were significantly shorter than control group patients, blood loss was significantly less than control group patients (P<0.05);2)After surgery, patients AKSS knee function scores were significantly higher than control group patients(P<0.05);3)After surgery, observation group patients’ adverse events incidence was significantly lower than control group patients (P<0.05). Conclusion:Minimally invasive percutaneous plate osteosynthesis can effectively optimize the surgical procedure to improve postoperative joint function and reduce adverse events healing is ideal tibia fracture mode of operation.

Social media,such as WeChat and microblog,have become the platform for domestic college and university libraries to popularize and provide information service for their teachers and students.The use of social media,public account,menu functions,information pushing of WeChat and running of official miroblog in domestic medical college and university libraries were investigated,which showed the problems in running of social media in medical college and university libraries.Measures for the solution of such problems were put forward.The fact that social media are expected to become the ubiquitous carrier of information service in medical college and university libraries and help medical college and university libraries to improve their core competitive power.

Objective To investigate the clinical effect and safety of elective surgery applying in obstructive colon cancer,to provide a reference for clinical surgery.Methods 70 patients with obstructive colon cancer were selected,they were divided into control group and observe group,35 cases in each group.Surgery was used right after patients were diagnosed in the control group,conservative treatment was used in the observation group before surgery. The clinical effect and safety were compared between the two groups.Results The rate of colon cancer excisionⅠperiod anastomosis in the observation group was 91.43% (32 /35 ),which was higher than the control group (54.29%),the difference was statistically significant(χ2 =9.456,P =0.001).The incidence rates of ileocolic anas-tomosis and colostomy of the observation group were 2.86%,5.71%,which were lower than those of the control group,the differences were statistically significant(χ2 =12.328,P =0.000;χ2 =7.983,P =0.003).5 patients of the observation group had 6 complications,the incidence rate of complication was 14.29%,20 patients of the control group had 25 complications,the incidence rate of complication was 57.14%,the difference was statistically significant (χ2 =8.885,P =0.002).Conclusion Elective surgical disposable eradication rate is higher applying in obstructive colon cancer patients with good safety,which could be a priority in clinical application.

Objective To explore multiple recurrence of Kawasaki disease (KD).Methods The clinical data of one child with multiple recurrent KD in two years was retrospectively analyzed.Results A four-year boy had his ifrst episode of classic KD without coronary artery abnormality at 2 years old. He had since had four episodes incomplete KD within 2 years, all of which were manifested by fever accompanied with neck lymph node swelling, bilateral conjunctival congestion, red and chap lips and strawberry-like tongue. White blood cell count, C reaction protein, and erythrocyte sedimentation rate were all increased. No purulent changes of cervical lymph nodes were detected by ultrasound. After intravenous infusion with high doses of gamma globulin, the fever was brought down, and the duration of fever was 6~8 d. The fever free intervals between 2 adjacent episode were about 2.5, 1.5, 4.5, and 13.5 months. The clinical manifestations and genetic test results were not consistent with the periodic fever, aphthous stomatitis, pharyngitis, and cervical lymphadenitis syndrome (PFAPA).Conclusion Five episodes of KD within 2 years are rare and a long-term follow-up is warranted.

With the ascending attack rate of anovulatory infertility year by year, people also began to pay attention to its treat methods. According to Doctor Ma Kun,who are engaged in clinical work about the treatment for anovulatory infertility, kidney deficiency is the basic pathogenesis and blood stasis is an important factor that has been through. Flexible use of tonifying the kidney and promoting blood circulation treatment of anovulatory infertility in clinic, has achieved remarkable curative effect. Director Ma adjusts menstruation by the different periods, and regulates both patients' negative emotions and sleep quality. Through years of clinical experience accumulation, Director Ma gradually formes special treatment of anovulatory infertility by flexibly using of tonifying the kidney and promoting blood circulation individually.
Adult ; Anovulation ; drug therapy ; physiopathology ; Blood Circulation ; drug effects ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Infertility, Female ; drug therapy ; physiopathology ; Kidney ; drug effects ; physiopathology