Objective To evaluate the effect of propofol,sevoflurane,and dexmedetomidine on respiratory complications in children undergoing fiberoptic bronchoscopy(FOB).Methods This double-blind randomized clinical trial was conducted among 120 children aged 1 month to 3 years undergoing FOB.The patients were randomized into 3 groups(n=40)for anesthesia induction with sevoflurane inhalation,1 mg/kg propofol,or 1 μg/kg dexmedetomidine before bronchoscopy,and the changes in hemodynamic parameters,sedation level,and respiratory complications during and after the procedure were assessed.Results The patients'heart rate during bronchoscopy was significantly lower and the mean arterial blood pressure significantly higher in dexmedetomidine group than in sevoflurane and propofol groups(P<0.05).Cough during bronchoscopy did not occur in any of the cases in propofol group,while the highest frequency of cough was recorded in dexmedetomidine group.The incidence of laryngospasm in the propofol group(12.5%)was significantly lower than those in sevoflurane and dexmedetomidine groups(30%and 32.5%,respectively)(P<0.05).Conclusion Sevoflurane and propofol are safe and suitable for anesthesia induction in children below 3 years of age undergoing diagnostic FOB and can achieve better sedative effect and lower the incidences of cough and respiratory complications as compared with dexmedetomidine.

Objective To evaluate the effect of propofol,sevoflurane,and dexmedetomidine on respiratory complications in children undergoing fiberoptic bronchoscopy(FOB).Methods This double-blind randomized clinical trial was conducted among 120 children aged 1 month to 3 years undergoing FOB.The patients were randomized into 3 groups(n=40)for anesthesia induction with sevoflurane inhalation,1 mg/kg propofol,or 1 μg/kg dexmedetomidine before bronchoscopy,and the changes in hemodynamic parameters,sedation level,and respiratory complications during and after the procedure were assessed.Results The patients'heart rate during bronchoscopy was significantly lower and the mean arterial blood pressure significantly higher in dexmedetomidine group than in sevoflurane and propofol groups(P<0.05).Cough during bronchoscopy did not occur in any of the cases in propofol group,while the highest frequency of cough was recorded in dexmedetomidine group.The incidence of laryngospasm in the propofol group(12.5%)was significantly lower than those in sevoflurane and dexmedetomidine groups(30%and 32.5%,respectively)(P<0.05).Conclusion Sevoflurane and propofol are safe and suitable for anesthesia induction in children below 3 years of age undergoing diagnostic FOB and can achieve better sedative effect and lower the incidences of cough and respiratory complications as compared with dexmedetomidine.

Background: Precise assessment of preoperative mental health and psychological determinants may be useful in identifying patients at risk for poor postoperative outcomes of total knee arthroplasty (TKA). The aim of this study was to investigate the influence of psychological status and physical and mental health on the outcome of patients undergoing TKA. Methods: Fifty-two patients undergoing unilateral TKA were assessed preoperatively with Oxford Happiness Inventory, Eysenck Personality Inventory, 12-item short form health survey (SF-12), and Knee Injury and Osteoarthritis Outcome Score (KOOS) for evaluating depression, personality traits, physical and mental health, and function, respectively. At 1 year after surgery, health-related quality of life (HRQL) and function were assessed using the SF-12 and KOOS. Results: HRQL and function of all personality traits increased significantly after TKA, without significant difference among them. Extroversion and neuroticism did not have significant correlation with subjective well-being, HRQL, and function before and after surgery. Subjective well-being and the baseline physical and mental health scores were correlated strongly and directly with postoperative physical component summary, mental component summary, and KOOS scores and their improvement. Among many factors that significantly affected the outcomes of TKA, the only independent predictor of physical, mental, and functional outcome was depression. Conclusions Outcomes of surgery were not significantly different among diverse personality traits. Patients with less depressive symptoms and higher baseline mental and physical scores had significantly greater improvement in HRQL after surgery. The only independent factor affecting the physical, mental, and functional outcome was depression.