Objective To design and develop a quadrature demodulation circuit for detection of ampli-tude and phase information in EIT measurement. Methods A model structure file was built in matlab/simulink using the elements in Ahera DSP Builder and verified by simulated stimulation. Then the model file was convert-ed to VHDL file via Signal Compiler, and the synthesis, adaptation, simulation and hardware implementation were accomplished. Results The simulation and testing results show that the circuit can extract the real and imagi-nary information of the measured signal and it also meets the EIT measuring requirement, with acceptable mea-sure error. Conclusion The demodulation circuit based on DSP Builder can precisely give real and imaginary information of EIT and provides technological support for full-information complex impedance measurement.

Objective To investigate the effect of atorvastatin calcium with different doses on inflammatory cytokine and carotid atherosclerotic plaque of patients with cerebral infarction.Methods One hundred and seventy-eight patients with cerebral infarction admitted into our hospital from January 2014 to June 2015 were divided into low dose (LD) group and high dose (HD) group.Ninety patients in LD group were treated with atorvastatin calcium in a dose of 10 mg/d,and eighty-seven patients in HD group were treated with atorvastatin calcium in a dose of 20 mg/d.The serum levels of lipid including TC,TG,LDL-C,HDL-C,inflammatory cytokine including hs-CRP,IL-6,TNF-α,and carotid atherosclerotic plaque of both groups were analyzed and compared before and after treatment.Results After six months of treatment,the serum levels and inflammatory cytokine of patients in both groups showed remarkable improvement (P ＜ 0.05),and those in HD group were significantly better than those of LD group (P ＜ 0.05).Additionally,compared with those before treatment,changes in carotid atherosclerotic plaque of patients in LD group were not obvious,while those in HD group markedly decreased,and which were significantly lower than those of LD group (P ＜ 0.05).Conclusion Atorvastatin calcium with HD of 20 mg/d showed a better capability on improving serum levels of lipid,inflammatory cytokine,and carotid atherosclerotic plaque of patients with cerebral infarction than those with LD of 10 mg/d.

Objective To investigate the values of recombinant tissue type plasminogen activator (rt-PA)) in the treatment of acute cerebral infarction complicated with atrial fibrillation.Methods Used the prospective research methods,74 patients of acerebral infarction complicated with atrial fibrillation in Xi'an XD Group Hospital from February 2015 to August 2016 were selected and were equally divided into the observation group and the control group accorded to the principle of random envelope drawing.The control group was treated with urokinase intravenous thrombolytic therapy,the observation group was treated with rt-PA intravenous thrombolytic therapy,and the prognosis of the two groups were observed.Results There were no significant differences in gender,age,time window,disease,systolic blood pressure and diastolic blood pressure compared between the two groups.The treatment efficiency in the observation group and control group were 94.6％ and 75.7％,the observation group was significantly higher than that of the control group (P ＜ 0.05).After treatment,the mRS scores in the observation group and the control group were (5.22± 1.83) points and (7.29± 1.45) points,were significantly lower than those before treatment of (10.24± 1.31) points and (10.19 ± 1.52) points (P ＜ 0.05),and the observation group was significantly lower than the control group (P ＜ 0.05).In the observation group,the symptomatic intracerebral hemorrhage and non symptomatic cerebral hemorrhage were 5.4％ and 2.7％ respectively,so that were 18.9％ and 16.2％ in the control group that the observation group were significantly lower than those of the control group (P ＜ 0.05).Conclusion Intravenous thrombolysis with recombinant tissue type plasminogen activator of patients with acute cerebral infarction combined with atrial fibrillation is safe and effective,it can promote the improvement of neurological function,and has good application value.

Objective To investigate the safety,feasibility and effectivity of laparoscopic left hemihepatectomy for left hepatolithiasis.Methods From Jan.2005 to Dec.2013,36 patients with left hepatolithiasis underwent laparoscopic left hemihepatectomy (group LH),in comparison with 39 other patients who underwent conventional open left hemihepatectomy (group OH).The blood supply to left liver was dissected and cut off first.The liver parenchyma was transected and the left hepatic vein was dissected and clamped.Intraoperative choledochoscopy was carried out through the stump of left bile duct,laparoscopic choledocholithotomy and T-tube drainage were carried out when stones were found in the common or right bile duct.Blood loss,rate of residual stone,complication rate between the two groups were compared.Results The success rate of operation was 100％.Compared with group OH,group LH had shorter postoperative hospitalization,less incision infection and fewer analgesia needed(t =3.75,x2 =4.11,x2 =22.12,P ＜0.05).There was no statistical difference for blood loss,rate of transfusion,and postoperative complications such as bile leakage,pleural effusion,ascites,residual stones (t =0.66,x2 =0.70,x2 =0.01,x2 =0.52,x2 =0.01,x2 =0.28,x2 =0.01,P ＞ 0.05).Conclusions Laparoscopic left hemihepatectomy is safe,feasible,and effective for hepatolithiasis of the left liver lobe.

Objective To investigate the mental health and the affecting factors on children cochlear implants and to provide the reference of comprehensive rehabilitation for them.Methods We used the Psychological Ques-tionnaire for 3~6 Years Children to evaluate the mental health status of 1 6 6 children of 3~4 years old with cochlear implants,and compare those with the standard values of children with normal hearing.We studied the affecting fac-tors on their psychological development.Results The pass rates in action,emotion and will,cognitive ability,sociali-ty,living habits and speech ability of children with cochlear implants decreased as their age increased.The scores of action,emotion and will,cognitive ability,sociality,living habits and speech ability of children with cochlear im-plants increased as the use time increased.The affecting factors on the psychological development of children with cochlear implants were the time length of usage and their residences before operation.Conclusion There were differ-ences between the children with cochlear implants and normal hearing in psychological development.We should fo-cus on their development of hearing and speech ability,and the psychological development.

Objective To analyse the mental health of adolescents with cochlear implants and provide the ref‐erence for programming the personalize rehabilitation schedule of audio - speech -psychological .Methods The mental health test(MHT) was used to evaluate the mental health status of 60 adolescent with cochlear implants ,and compared with those of adolescent with normal hearing .Results The incidence of psychological problems was 3 .33% in adolescent with cochlear implants .The hypersusceptilility scores of the group of cochlear implants (5 .63 ± 2 .22) was higher than that of in normal hearing group(4 .05) in ,which was significantly different(P<0 .01) . The body syndrome scores in the cochlear implants group (4 .03 ± 2 .72) was lower than that of in normal hearing group(4 .99) ,which was significantly different(P<0 .01) .The phobic tendency scores in cochlear implants group (1 .95 ± 2 .01)was significantly lower than that of in normal hearing group (3 .06)(P<0 .01) .Conclusion The over‐all mental health of adolescent with cochlear implants is good .Cochlear implants can help them improve hearing and speech function ,and improve quality of life ,but they still need parents ,teachers and the community to pay more at‐tention and care to help them get through adolescence ,and return to mainstream society .

OBJECTIVE: To assess the evaluation on auditory rehabilitation effect for 42 deaf children with GJB2 gene mutation after cochlear implantation to provide a reference for the cochlear implant effect evaluation of such patients. METHOD: To conduct the detection on common genetic deafness gene mutation hotspots of hearing impaired children with cochlear implantation. To conduct auditory rehabilitation effect evaluation on 42 cases of patients with GJB2 genetic deafness after 3 months, 6 months and 12 months of the operation respectively. The single factor repeated measure ANOVA was applied to analyze whether there were significant difference among the results of initial consonant of a Chinese syllable recognition at 3 different stages after the operation, the results of vowel of a Chinese syllable recognition at 3 different stages after the operation, and the results of two-syllable recognition at 3 different stages after the operation. RESULT: 235delC is the high-incidence mutational site in 42 cases of patients with GJB2 genetic deafness, the total detection rate is up to 90.48%. There were significant differences in the initial consonant of a Chinese syllable recognition rate, the vowel of a Chinese syllable recognition rate, the two-syllable recognition rate as well as the vowel of a Chinese syllable recognition rate after 3 months, 6 months and 12 months of the operation (P < 0.01). CONCLUSION Cochlear implantation is a safe and effective measure for auditory reconstruction, it can help patients with GJB2 hereditary severe sensorineural deafness to improve auditory speech recognition.
Asian Continental Ancestry Group ; Child ; Cochlear Implantation ; Connexin 26 ; Connexins ; genetics ; Deafness ; genetics ; rehabilitation ; Hearing Loss, Sensorineural ; genetics ; rehabilitation ; Humans ; Language ; Mutation

According to the multi-information characteristic of pulse tracings in traditional Chinese medicine(TCM) and the dynamic analysis and identification technique of sonogram,the multi-information detection system of pulse examination was constructed by combining B-type ultrasound and flexible transducer.It made information integration of supersonic dynamic image,pressure pulse wave,photoelectric capacity pulse wave and electrocardiogram,and though the aggregate analysis of computer information processing technique,established the pulse tracings signature analysis method,formed optimized solving scheme for describing the four attributes("location,velocity,shape and potential") of pulse examination in TCM.From the multi-information data of healthy people's pulse tracings collected by this system,it can be infer that the new method of objectification of pulse examination referred in this article is feasible,and have gain the prospective effect.It provides a new method and characteristic data for the clinical study of objectification of pulse examination and teaching of TCM.

Objective The aim of this study is to evaluate word recognition abilities in 4-talker babble noise (BN) in children with normal hearing (NH), and to explore the lexical effects, age on speech recognition ability in children.Methods Children of 3~6 years old with normal hearing (N=212)were participated in this study.One hundred and twenty-four children were performed under the quiet conditions,while 88 were performed in 4-talker babble noise.The standard-Chinese version of the lexical neighborhood test was used to assess spoken word recognition performance.The speech level was 70 dB SPL, and signal to noise ratio (SNR) was chosen 4 dB in BN.Results The correct scores of the NH children in quiet for the DE, DH, ME, and MH words were 96.45%±5.17%, 88.87%±7.73%, 91.90%±7.31% and 82.38%±7.95%, while the scores in BN were 85.34%±11.23%, 66.42%±11.08%, 68.81%±15.99% and 48.58%±12.81%, respectively.The word-recognition performance in BN was significantly poorer than that in quiet.The word recognition scores showed that the lexical effects were significant in the BN (P<0.05).Children scored higher with dissyllabic words than with monosyllabic words;easy words scored higher than hard words in both quiet and noisy environments.The word-recognition performance also increased with age in each lexical category in the 3-to 6-year-old NH children.Conclusion Age and lexical characteristics of words had significant influences on the performance of Mandarin-Chinese word recognition in BN.The lexical effects were more noticeable under noise listening conditions than in quiet.The word-recognition performance in noise increased with age in NH children of 3-to 6-years old in noise and had not reached adult-like performance at 6 years of age.

Objective To study normal hearing children's speech perception in Speech Spectrum -Shaped Noise (SSN) and Babble Noise (BN) using the Mandarin lexical neighborhood test .Methods Thirty -four children with normal hearing were included in this study and randomly assigned to the SSN group and the BN group .Each child was given the 12 lists of Mandarin lexical neighborhood test ,word recognition scores were acquired at different SNRs .Results SNR50 of dissyllablic easy word lists ,dissyllablic hard word lists ,monosyllable easy word lists , monosyllable hard word lists in SSN were -3 dB ,-0 .5 dB ,-1 dB and 3 .5 dB ,respectively ;SNR50 of the four categories lists in BN were -3 dB ,2 dB ,0 .5 dB and 10 dB ,respectively .Lexical effects had a significant influence on spoken word recognition in noise .Especially ,word recognition scores of easy words were higher than those of hard words ,dissyllablic words were better than monosyllable words .Conclusion The masking effects of babble noise on spoken speech perception are stronger than speech spectrum -shaped noise for 3-6 year-old normal hearing chil‐dren .Lexical effects also affet children's speech recognition in noise .