Objective To investigate the quality of life (QOL) of dysphagic patients after stroke and the factors related to it. Methods One hundred patients with dysphagia after stroke from January, 2014 to February, 2015 were investigated with the Swallowing Disorder Pa-tients Quality of Life Scale (SWAL-QOL). The general and special data of the patients were collected, and were analyzed with univariate analysis and Ordinal regression. Results With univariate analysis, there was significant difference in scores of SWAL-QOL among the pa-tients of various ages, courses, education levels, complications, treatment time, ways of eating, grades of drinking water test and swallowing function scores (P<0.01). Ordinal regression analysis showed that the high scores of SWAL-QOL was more probable in the patients aged 50-59 years old, with higher education level, no complication and less grade of drinking water test. Conclusion Intervention targeted to the risk factors may improve the QOL of patients with dysphagia after stroke.

Objective: To optimize the formulation and prepration of tranexamic acid (TA) transfersomes by central composite design-response surface method. Methods: The transfersomes were prepared using the reverse rotary evaporation method. The effects of phosphatidylcholine (SPC)-cholesterol (CH) ratio, SPC-drug ratio, and the concentration of sodium deoxycholic acid on the entrapment efficiency (EE) were investigated, the results were fitted with binomial equation, and the optimal formulation was predicted by response surface method. Results: The preparation conditions were optimized as SPC-CH (2:1), SPC-drug (6:1), and the concentration of sodium deoxycholic acid 20 mg. Under these conditions, the evaluated EE, drug-loading, average partical size, and Zeta potential of TA transfersomes were (81.28 ± 1.06)%, (4.67 ± 0.28)%, (105.3 ± 7.2) nm, and (-38.5 ± 2.3) mV. The deviation of measured and predicated values was smaller. Conclusion: The central composite design-response surface method is applicable for the optimization of TA transfersomes and the resulting optimal preparation technique is stable and feasible.

The structure and characteristics of the soluble exopolysaccharide(PS-238) produced by Alcaligenes sp.NX-3 were studied.The analytic sample was prepared by ethanol precipitation then proteins were removed by the Sevag method.The components of polysaccharide were identified by TLC、 GC and chemical method after acid hydrolysis as: glucose,mannose,rhamnose and glucuronic acid.By means of IR and periodate oxidation,it showed that the polysaccharide was mainly consisting of(1→3)and(1→4) glucosidic linkages.The relation between viscosity and shear rate、concentration、temperature、pH and salts was investigated.The results showed that the solution of PS-238 is a typical pseudoplastic liquid,having high viscosity at low concentrations.The viscosity of 1%PS-238 water solution could reach 3300cp at 25℃.It has the excellent stability towards pH2~13,also has outstanding property of viscosity retention even at temperatures up to 150℃.Some kinds of salts were cooperated with PS-238 as a thickening agent.

Objective To summarize the clinical features,efficacy and prognosis of 42 children patients with severe viral myocarditis(VM).Methods To retrospecitivly analyze the clinical data about 42 children patients with severe VM.Results There were the lack of typical clinical features and ancillary inspection targets on diagnosis,and no effects on clinical treatment,so that it was being concealed in the basis of disease symptoms and delayed treatment.Amidst this group patients(42 cases)of children with severe viral myocarditis,there was 76.2% patients with the heart symptoms and 47.6% patients with serious cardiac complications(such as acute heart failure,cardiogenic shock,fatal arrhythmia).Therapeutic result:total effective rate 78.6%,morality 11.9%,14.3% to chronic.Conclusion To diagnose Viral myocarditis in children it hould be combined with the history of palpitations,chest tightness,and other clinical symptoms and objective indicators of myocardial damage.Because of no specific means of treatment,we should be focus on comprehensive treatment and timely care and rescue critically ill patients.The majority of children patients with severe VM are favorable prognosis and a very small number to chronic.

Objective To examine the academic emotions and its relationship with academic self-efficacy among secondary special school students. Methods 352 secondary special school students were collected as the subjects.All subjects were tested with academic emotions questionnaire and academic self-efficacy questionnaire and analyzed the result of the test by multivariate analysis of variance,correlation analysis and linear regression analysis. Results Scores on enjoyment,anxiety,anger,depression,total scores on positive-high arousal academic emotions and negative-high arousal academic emotions of secondary special school girls(27.88±3.84,24.77±5.03,18.03±3.37,18.14±3.65,59.33±7.98,57.48±10.49,respectively)were higher than those of boys(26.41±4.55,22.38±5.71,17.01±3.91,16.07±3.94,57.46±9.20,53.45±11.76,respectively),(P<0.05).The academic emotions' differences among different grades of secondary special school students were not significant(F-(1,348)=1.275,P=0.226).The interaction of gender and grade on academic emotions was not significant(F-(1,348)=1.057,P=0.397).Academic emotions and academic self-efficacy was interrelated(r=-0.513～0.685).The result of multiple regression analysis showed that each factor of academic self-efficacy played a significant predictor role on academic emotions(β=-0.631～0.462,P<0.01). Conclusion The academic emotions' differences between secondary special school boys and girls are significant. Academic self-efficacy is closely related to academic emotions.

Objective:To assess the effect and mechanism of ClassⅢ malocclusions treatment with Frankel-Ⅲ appliance and reverse Twin-block appliance. Methods:Twenty subjects of ClassⅢ malocclusion were included in this study(9 males,11 females). Among them, 10 subjects were randomly selected for treatment with reverse Twin-block appliance (T group) and 10 subjects for Frankel-Ⅲ appliance (F group). All patients were treated all the day for total of 4-11 months. The cephalometric records of these subjects were examined before and after treatment. The acquired data were processed with SPSS 10.0. Results: The results showed a mandible receded backward in both groups. Both group could accelerate the development of the maxillary bone. But the Frankel-Ⅲ was more effective. F group had significant effects of uprighting upper frontal teeth and flaring lower teeth. the average treatment time was 6.5 months in reverse twin-block appliance therapy group and 9 months in Frankel-Ⅲ appliance group. Conclusion: Both reverse Twin-block appliance and Frankel-Ⅲ appliance can treat angle classⅢ malocclusions effectively. The effects of maxillary changes of Frankel-Ⅲ appliance is better than reverse Twin-Block. Treatment period is shorter in T group than in F group.

Objective To explore the molecular targets and mechanisms that could influence the sensitivity of triple negative breast cancer (TNBC) to chemotherapy,to provide important references for the chemotherapy based on gene detection.Methods The gene expression dataset GSE43502 was downloaded from the Gene Expression Omnibus in National Center for Biotechnology Information (NCBI).Gene expression data preprocessing was conducted by R Programming.The differentially expressed genes in the TNBC patients that relapsed after chemotherapy compared with the non-relapsed ones were obtained.Besides,the Database for Annotation Visualization and Integrated analysis (DAVID) was used for functional analysis of those genes.The microRNA (miRNA) that might regulate the differentially expressed genes was obtained from the starBase database.Furthermore,Cytoscape was used for the construction of miRNA-gene regulation network.Results Three hundred and twelve differentially expressed genes were obtained.Some biological process related to cell membrane,metal ion homeostasis and pathways involved in immune and inflammatory were found to be enriched in those genes.Furthermore,171 miRNA that might regulate the differentially expressed genes were obtained and 553 miRNA-gene regulation pairs were formed.Conclusions hsa-miR-30d-5p,SIX4,etc.might influence the sensitivity of TNBC to chemotherapy through cell structure or immune system.

Desmoplastic small round cell tumor( DSRCT) is a kind of highly uncommon malignant tumor which is reported in very recent years.Since it has been firstly reported by Gerald in 1991,DSRCT has only a-round one hundred reported cases globally, and very limited cases domestically.This report illustrates the first case of DSRCT in our hospital so as to share and to discuss with clinicians.

Vitamin K deficiency is a common problem in neonates and infants,vitamin K deficiency bleeding can be life threatening.There is still a high incidence of vitamin K deficiency even if the prevention by retrospective analysis a large number of the global data.In recent years,with the increase of premature infants,incidence is higher than before,China is the same trend.There is no recognized prevention and treatment measures,and less related research data.Therefore,to carry out related investigation,to provide the basis for clinical prevention and treatment are an urgent task.

Rheumatoid arthritis (RA) is a common systemic autoimmune disease characterized by chronic inflammation of joints,bone and cartilage erosion,synovial hyperplasia,and the pathogenesis of RA is not clear.γδT cells are a new kind of phenotype and function T lymphocyte subsets,which mainly distribute in the mucosal and epithelial tissue and account for 1％-10％ of the total T cells in the peripheral blood,and bridge innate and adaptive immunity.γδT cells play an important role in the pathogenesis of RA by the functions of antigen-presenting capacity,secretion of proinflammatory cytokines,immunomodulatory effects,and auxiliary function for B cells.