1.Initial clinical outcomes of proton beam radiotherapy for hepatocellular carcinoma
Jeong Il YU ; Gyu Sang YOO ; Sungkoo CHO ; Sang Hoon JUNG ; Youngyih HAN ; Seyjoon PARK ; Boram LEE ; Wonseok KANG ; Dong Hyun SINN ; Yong Han PAIK ; Geum Youn GWAK ; Moon Seok CHOI ; Joon Hyeok LEE ; Kwang Cheol KOH ; Seung Woon PAIK ; Hee Chul PARK
Radiation Oncology Journal 2018;36(1):25-34
PURPOSE: This study aimed to evaluate the initial outcomes of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) in terms of tumor response and safety. MATERIALS AND METHODS: HCC patients who were not indicated for standard curative local modalities and who were treated with PBT at Samsung Medical Center from January 2016 to February 2017 were enrolled. Toxicity was scored using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Tumor response was evaluated using modified Response Evaluation Criteria in Solid Tumors (mRECIST). RESULTS: A total of 101 HCC patients treated with PBT were included. Patients were treated with an equivalent dose of 62–92 GyE10. Liver function status was not significantly affected after PBT. Greater than 80% of patients had Child-Pugh class A and albumin-bilirubin (ALBI) grade 1 up to 3-months after PBT. Of 78 patients followed for three months after PBT, infield complete and partial responses were achieved in 54 (69.2%) and 14 (17.9%) patients, respectively. CONCLUSION: PBT treatment of HCC patients showed a favorable infield complete response rate of 69.2% with acceptable acute toxicity. An additional follow-up study of these patients will be conducted.
Carcinoma, Hepatocellular
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Follow-Up Studies
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Humans
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Liver
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Proton Therapy
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Protons
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Radiotherapy
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Response Evaluation Criteria in Solid Tumors
2.The first private-hospital based proton therapy center in Korea; status of the Proton Therapy Center at Samsung Medical Center.
Kwangzoo CHUNG ; Youngyih HAN ; Jinsung KIM ; Sung Hwan AHN ; Sang Gyu JU ; Sang Hoon JUNG ; Yoonsun CHUNG ; Sungkoo CHO ; Kwanghyun JO ; Eun Hyuk SHIN ; Chae Seon HONG ; Jung Suk SHIN ; Seyjoon PARK ; Dae Hyun KIM ; Hye Young KIM ; Boram LEE ; Gantaro SHIBAGAKI ; Hideki NONAKA ; Kenzo SASAI ; Yukio KOYABU ; Changhoon CHOI ; Seung Jae HUH ; Yong Chan AHN ; Hong Ryull PYO ; Do Hoon LIM ; Hee Chul PARK ; Won PARK ; Dong Ryul OH ; Jae Myung NOH ; Jeong Il YU ; Sanghyuk SONG ; Ji Eun LEE ; Bomi LEE ; Doo Ho CHOI
Radiation Oncology Journal 2015;33(4):337-343
PURPOSE: The purpose of this report is to describe the proton therapy system at Samsung Medical Center (SMC-PTS) including the proton beam generator, irradiation system, patient positioning system, patient position verification system, respiratory gating system, and operating and safety control system, and review the current status of the SMC-PTS. MATERIALS AND METHODS: The SMC-PTS has a cyclotron (230 MeV) and two treatment rooms: one treatment room is equipped with a multi-purpose nozzle and the other treatment room is equipped with a dedicated pencil beam scanning nozzle. The proton beam generator including the cyclotron and the energy selection system can lower the energy of protons down to 70 MeV from the maximum 230 MeV. RESULTS: The multi-purpose nozzle can deliver both wobbling proton beam and active scanning proton beam, and a multi-leaf collimator has been installed in the downstream of the nozzle. The dedicated scanning nozzle can deliver active scanning proton beam with a helium gas filled pipe minimizing unnecessary interactions with the air in the beam path. The equipment was provided by Sumitomo Heavy Industries Ltd., RayStation from RaySearch Laboratories AB is the selected treatment planning system, and data management will be handled by the MOSAIQ system from Elekta AB. CONCLUSION: The SMC-PTS located in Seoul, Korea, is scheduled to begin treating cancer patients in 2015.
Cyclotrons
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Helium
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Humans
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Korea*
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Metallurgy
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Particle Accelerators
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Patient Positioning
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Proton Therapy*
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Protons*
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Radiation Oncology
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Respiratory System
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Seoul