BACKGROUND: In Asian countries, patients with a square-shaped lower face want a narrow chin as well as improvements in the mandibular angle contour, which is called a "V-line shape." Currently, various surgical techniques have been developed for mandibuloplasty. METHODS: We have developed an extended, long, curved ostectomy, which starts from the inferior mandibular margin below the lateral incisor to the angle, using reciprocating and oscillating saws. We also used a small round bur to grind the outer cortex of the chin and ramus. A total of 243 patients were included in this study from 2012 to 2014. RESULTS: To analyze aesthetic outcomes, we compared mandibular angles and gonial-gonial (G-G) distances on preoperative three-dimensional computed tomography scans with postoperative images. Mandibular measurements demonstrated significant increments in angle degrees on the right (115.2degrees+/-11.1 vs 129.3degrees+/-11.5, P<0.05) and left sides (112.2degrees+/-10.2 vs 130.4degrees+/-11.3, P<0.05). The G-G distance was reduced postoperatively from 123.7 mm+/-7.9 to 110.0 mm+/-3.5 (P<0.05). CONCLUSIONS: In this study, we demonstrate the effectiveness of our technique and assume that we can improve frontal shape and lateral contour with its use.
Asian Continental Ancestry Group ; Chin* ; Humans ; Incisor ; Mandible ; Mandibular Osteotomy ; Orthognathic Surgery ; Orthognathic Surgical Procedures

Background and Objectives: Tcfs and Lef1 are DNA-binding transcriptional factors in the canonical Wnt signaling pathway. In the absence of β-catenin, Tcfs and Lef1 generally act as transcriptional repressors with co-repressor proteins such as Groucho, CtBP, and HIC-5. However, Tcfs and Lef1 turn into transcriptional activators during the interaction with β-catenin. Therefore, the activity of Tcfs and Lef1 is regulated by β-catenin. However, the intrinsic role of Tcfs and Lef1 has yet to be examined. The purpose of this study was to determine whether Tcfs and Lef1 play differential roles in the regulation of self-renewal and differentiation of mouse ES cells. Methods: and Results: Interestingly, the expression of Tcfs and Lef1 was dynamically altered under various differentiation conditions, such as removal of LIF, EB formation and neuronal differentiation in N2B27 media, suggesting that the function of each Tcf and Lef1 may vary in ES cells. Ectopic expression of Tcf1 or the dominant negative form of Lef1 (Lef1-DN) contributes to ES cells to self-renew in the absence of leukemia inhibitory factor (LIF), whereas ectopic expression of Tcf3, Lef1 or Tcf1-DN did not support ES cells to self-renew. Ectopic expression of either Lef1 or Lef1-DN blocked neuronal differentiation, suggesting that the transient induction of Lef1 was necessary for the initiation and progress of differentiation. ChIP analysis shows that Tcf1 bound to Nanog promoter and ectopic expression of Tcf1 enhanced the transcription of Nanog. Conclusions The overall data suggest that Tcf1 plays a critical role in the maintenance of stemness whereas Lef1 is involved in the initiation of differentiation.