Objective: This systematic review and meta-analysis evaluated the accuracy of preoperative breast magnetic resonance imaging (MRI) features and tumor-to-nipple distance (TND) for diagnosing occult nipple-areolar complex (NAC) involvement in breast cancer. Materials and Methods: The MEDLINE, Embase, and Cochrane databases were searched for articles published until March 20, 2022, excluding studies of patients with clinically evident NAC involvement or those treated with neoadjuvant chemotherapy.Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 tool. Two reviewers independently evaluated studies that reported the diagnostic performance of MRI imaging features such as continuity to the NAC, unilateral NAC enhancement, non-mass enhancement (NME) type, mass size (> 20 mm), and TND. Summary estimates of the sensitivity and specificity curves and the summary receiver operating characteristic (SROC) curve of the MRI features for NAC involvement were calculated using random-effects models. We also calculated the TND cutoffs required to achieve predetermined specificity values. Results: Fifteen studies (n = 4002 breast lesions) were analyzed. The pooled sensitivity and specificity (with 95% confidence intervals) for NAC involvement diagnosis were 71% (58–81) and 94% (91–96), respectively, for continuity to the NAC; 58% (45–70) and 97% (95–99), respectively, for unilateral NAC enhancement; 55% (46–64) and 83% (75–88), respectively, for NME type; and 88% (68–96) and 58% (40–75), respectively, for mass size (> 20 mm). TND had an area under the SROC curve of 0.799 for NAC involvement. A TND of 11.5 mm achieved a predetermined specificity of 85% with a sensitivity of 64%, and a TND of 12.3 mm yielded a predetermined specificity of 83% with a sensitivity of 65%. Conclusion Continuity to the NAC and unilateral NAC enhancement may help predict occult NAC involvement in breast cancer. To achieve the desired diagnostic performance with TND, a suitable cutoff value should be considered.

This study assessed parental knowledge and utilization patterns of fluoride containing dentifrices in the context of youth oral health promotion. A direct questionnaire was administered to 168 parents of young patients who attended the Pediatric Dental Clinic at Yonsei University Dental Hospital between March and May 2024. The findings indicated that while a significant majority (94.6%) of parents acknowledged the importance of fluoride in adult oral care products, their understanding of the potential adverse effects was limited. The study found that 84.5% of children used fluoride toothpaste and 96.4% of parents considered fluoride toothpaste essential for their children. However, a considerable proportion (40.5%) used low-fluoride formulations and many parents lacked awareness of the fluoride concentration (42.3%) and the appropriate dosage for their children (61.3%). Notably, paternal parents had a higher likelihood of being uninformed about fluoride content (24.7%, p = 0.003) and the correct quantity of toothpaste (26.2%, p < 0.05) that children should use. These observations underscore the need for targeted education for fluoride-containing oral care products for parents. Precise guidelines on suitable fluoride toothpaste types and quantities tailored to the developmental stages in children are important for enhancing oral health outcomes in youth.

This study assessed parental knowledge and utilization patterns of fluoride containing dentifrices in the context of youth oral health promotion. A direct questionnaire was administered to 168 parents of young patients who attended the Pediatric Dental Clinic at Yonsei University Dental Hospital between March and May 2024. The findings indicated that while a significant majority (94.6%) of parents acknowledged the importance of fluoride in adult oral care products, their understanding of the potential adverse effects was limited. The study found that 84.5% of children used fluoride toothpaste and 96.4% of parents considered fluoride toothpaste essential for their children. However, a considerable proportion (40.5%) used low-fluoride formulations and many parents lacked awareness of the fluoride concentration (42.3%) and the appropriate dosage for their children (61.3%). Notably, paternal parents had a higher likelihood of being uninformed about fluoride content (24.7%, p = 0.003) and the correct quantity of toothpaste (26.2%, p < 0.05) that children should use. These observations underscore the need for targeted education for fluoride-containing oral care products for parents. Precise guidelines on suitable fluoride toothpaste types and quantities tailored to the developmental stages in children are important for enhancing oral health outcomes in youth.

This study assessed parental knowledge and utilization patterns of fluoride containing dentifrices in the context of youth oral health promotion. A direct questionnaire was administered to 168 parents of young patients who attended the Pediatric Dental Clinic at Yonsei University Dental Hospital between March and May 2024. The findings indicated that while a significant majority (94.6%) of parents acknowledged the importance of fluoride in adult oral care products, their understanding of the potential adverse effects was limited. The study found that 84.5% of children used fluoride toothpaste and 96.4% of parents considered fluoride toothpaste essential for their children. However, a considerable proportion (40.5%) used low-fluoride formulations and many parents lacked awareness of the fluoride concentration (42.3%) and the appropriate dosage for their children (61.3%). Notably, paternal parents had a higher likelihood of being uninformed about fluoride content (24.7%, p = 0.003) and the correct quantity of toothpaste (26.2%, p < 0.05) that children should use. These observations underscore the need for targeted education for fluoride-containing oral care products for parents. Precise guidelines on suitable fluoride toothpaste types and quantities tailored to the developmental stages in children are important for enhancing oral health outcomes in youth.