1.NADPH oxidase inhibitor development for diabetic nephropathy through water tank model
Hye Eun LEE ; Seunghwan SHIM ; Yongseok CHOI ; Yun Soo BAE
Kidney Research and Clinical Practice 2022;41(Suppl 2):S89-S98
Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated cell signaling. Although excessive levels of ROS are harmful, moderated levels of ROS are essential for normal physiological function. Therefore, regulating cellular ROS levels should be an important concept for development of novel therapeutics for treating diseases. The overexpression and hyperactivation of NADPH oxidase (Nox) can induce high levels of ROS, which are strongly associated with diabetic nephropathy. This review discusses the theoretical basis for development of the Nox inhibitor as a regulator of ROS homeostasis to provide emerging therapeutic opportunities for diabetic nephropathy.
2.Cutaneous Mycobacterium massiliense Infection Associated with Acupuncture.
Jun Hwan KIM ; Seunghwan OH ; Ji Young JUN ; Joon Ho SHIM ; Ji Hye PARK ; Dong Youn LEE
Korean Journal of Dermatology 2016;54(1):75-76
No abstract available.
Acupuncture*
;
Mycobacterium*
3.Cutaneous Metastasis of Rhabdomyosarcoma Originated from Maxillary Sinus in a Young Adult Female.
Jun Hwan KIM ; Seunghwan OH ; Ji Young JUN ; Joon Ho SHIM ; Ji Hye PARK ; Dong Youn LEE
Annals of Dermatology 2016;28(4):519-521
No abstract available.
Female*
;
Humans
;
Maxillary Sinus*
;
Neoplasm Metastasis*
;
Rhabdomyosarcoma*
;
Young Adult*
4.A Case of Serious Complication after Cryotherapy.
Jun Hwan KIM ; Seunghwan OH ; Ji Young JUN ; Joon Ho SHIM ; Ji Hye PARK ; Jong Hee LEE ; Dong Youn LEE ; Joo Heung LEE ; Jun Mo YANG
Korean Journal of Dermatology 2016;54(3):203-205
Cryotherapy is a simple, relatively inexpensive therapeutic modality that is widely-used in clinical practice. It is especially appropriate for patients with an intolerance to anesthesia as well as high risk factors for developing hypertrophic scars after surgery. It can be applied to skin lesions located close to vital structures such as vessels and nerves. Potential side effects include pain, hemorrhage, edema, blisters, infection, hypopigmentation, and sensory damage. There are a numerous reports in the literature describing the side effects of cryotherapy. However, cases with severe complications have rarely been reported as yet. Herein, we report a case of serious complications of cryotherapy, a result of the course of treatment for linear porokeratosis.
Anesthesia
;
Blister
;
Cicatrix, Hypertrophic
;
Cryotherapy*
;
Edema
;
Hemorrhage
;
Humans
;
Hypopigmentation
;
Porokeratosis
;
Risk Factors
;
Skin
5.Analysis of clinical risk factors of failed electrical cardioversion in patients with persistent atrial fibrillation or atrial flutter
Ki‑Hun KIM ; Ha‑Young CHOI ; Jino PARK ; Yeo‑Jeong SONG ; Seunghwan KIM ; Dong‑Kie KIM ; Sang‑Hoon SEOL ; Doo‑Il KIM ; Pil‑Sung YANG ; Hong Euy LIM ; Junbeum PARK ; Jae‑Min SHIM ; Jinhee AHN ; Sung Ho LEE ; Sung Il IM ; Ju Youn KIM
International Journal of Arrhythmia 2023;24(3):17-
Background:
Although rhythm control could be the best for symptomatic atrial fibrillation (AF), some patients fail to achieve sinus rhythm (SR). This study aimed to identify clinical risk factors of failed electrical cardioversion (ECV).
Methods:
A total of 248 patients who received ECV for persistent AF or atrial flutter (AFL) were retrospectivelyreviewed. Patients were divided into three groups: Group 1 maintained SR for > 1 year, group 2 maintained SR ≤ 1 yearafter ECV, and group 3 failed ECV. SR maintenance was assessed using regular electrocardiography or Holter monitoring.
Results:
Patients were divided into group 1 (73, 29%), group 2 (146, 59%), and group 3 (29, 12%). The mean ageof patients was 60 ± 10 years, and 197 (79%) were male. Age, sex, and baseline characteristics were similar amonggroups. However, increased cardiac size, digoxin use, heart failure (HF), and decreased left ventricular ejection frac‑ tion (LVEF) were more common in group 3. Univariate analysis of clinical risk factors for failed ECV was increasedcardiac size [hazard ratio (HR) 2.14 (95% confidence interval [CI], 1.06–4.34, p = 0.030)], digoxin use [HR 2.66 (95% CI, 1.15–6.14), p = 0.027], HF [HR 2.60 (95% CI, 1.32–5.09), p = 0.005], LVEF < 40% [HR 3.45 (95% CI, 1.00–11.85), p = 0.038], and decreased LVEF [HR 2.49 (95% CI, 1.18–5.25), p = 0.012]. Among them, HF showed clinical significance only by multivariate analysis [HR 3.01 (95% CI, 1.13–7.99), p = 0.027].
Conclusions
Increased cardiac size, digoxin use, HF, LVEF < 40%, and decreased LVEF were related to failed ECV for persistent AF or AFL. Among these, HF was the most important risk factor. Further multi-center studies including greater number of participants are planned.