No abstract available.

It has been known that the interconnection between the gervous, endocrine and immune system are largely mediated through regulatory soluble factors such as neruopeptides, cytokines and hormones. Capsaicin, the pungent principle of hot peppers, is a neurotoxin that affects primary sensory neurons of the C and A-b type and depletes primary sensory neurons (polymodal nociceptors) of neuropeptides like tachykinin. In this study capsaicin was used to explore the possible role of the neruons on the expression of cellular and humoral immune responses and TNF-a prodcution. Mice were pretreated with s.c. injections in the neck region with a single dose of 100 u,g of capsaicin per mouse before immunization. ...continue...
Anaphylaxis* ; Animals ; Capsaicin* ; Carcinogenesis* ; Cytokines ; Immune System ; Immunity, Humoral ; Immunization ; Mice* ; Neck ; Neuropeptides ; Sensory Receptor Cells ; Tachykinins

No abstract available.
Diabetic Neuropathies ; Humans

Acoustics ; Child ; Cleft Palate ; Humans ; Korea

Carotidynia is defined as an atypical craniofacial pain syndrome caused by the dilatation or distension of the extracranial arteries. We report an unusual case of carotidynia mimicking trigeminal neuralgia caused by an arterioscle-rotic tortous carotid artery. A 68-year-old woman suffered from frequent episodes of severe electrical shock-like radiating pain around her left ophthalmic and maxillary division of the trigeminal nerve for 5 years. Initially, under the impression of trigeminal neuralgia, carbamazepine was tried. She was reevaluated due to an unsatisfactory pharmacological response. On examination, no abnormalities were found on the craniofacial region except for a tortous pulsating tender mass on the region of the left carotid artery. Routine laboratory findings and a connective tissue study were normal. Neck sonography and a 4-vessel angiography showed a tortous left internal carotid artery with stenosis extending near to the skin. The patient was treated for 2 weeks with a nonsteroidal anti-inflammatory agent, steroids, a prophylctic beta blocker, and a TCA antidepressant. The pain gradually subsided.
Aged ; Angiography ; Arteries ; Carbamazepine ; Carotid Arteries ; Carotid Artery, Internal ; Connective Tissue ; Constriction, Pathologic ; Dilatation ; Facial Neuralgia ; Female ; Humans ; Neck ; Skin ; Steroids ; Trigeminal Nerve ; Trigeminal Neuralgia*

The anesthetic properties on blockade of tourniquet pain of hyperbaric tetracaine (T-caine) and bupivacaine (marcaine) with or without epinephrine administered intrathecally were compaired in randomized study involving fourty healthy surgical patients. This investigation employed solutions of the two agents with or without epinephrine that contained equal dose (13 mg), concentration (0.5%), and volume (3ml). No statistically significant difference in height, anesthetic time, tourniquet time, tourniquet pressure, and sensory blockade level were observed between the four groups. Tourniquet pain or inadequate anesthesia did not occur in epinephrine-mix groups, But occurred in 20% of the patients in the tetracaine (t-caine) group & bupivacaine (marcaine) group each other. The results suggest that equal concentrations and dosages of hyperbaric tetracaine (T-caine) and bupivacaine (Marcaine) possessed similar anesthetic qualities on blockade of tourniquet pain following subarachnoid administration.
Anesthesia ; Bupivacaine* ; Epinephrine ; Humans ; Tetracaine* ; Tourniquets*

No abstract available.
Giant Cell Arteritis*

Major depressive disorder with psychotic features is fairly common but difficult to be diagnosed and managed. The patients with psychotic depression have psychomotor impairments, guilt, suicidal ideation or attempt, and neuropsychological impairments. Compared with non-psychotically depressed patients, these patients exhibit more frequent relapses and recurrences and have increased use of medical services, greater disability, more social and occupational impairments, and a poorer clinical course. They demonstrate distinct biological abnormalities in various studies. Several studies support a relationship between bipolar affective disorder and psychotic depression. The combination of an antidepressant and an antipsychotic or electroconvulsive therapy may be most efficacious treatments for psychotic depression. The combination of a selective serotonin reuptake inhibitor and an atypical antipsychotic may have particular relevance for the treatment of psychotic depression because of the potential for decreased risk of side effects, as well as possible antidepressant properties of an atypical antipsychotic itself. Additionally, glucocorticoid antagonist may have as good or better efficacy for the disorder. This article focused on recognizing the characteristics of psychotic depression, favorable treatment options, and new treatments under investigation.
Antidepressive Agents ; Antipsychotic Agents ; Depression ; Depressive Disorder, Major* ; Electroconvulsive Therapy ; Guilt ; Humans ; Mood Disorders ; Psychomotor Disorders ; Recurrence ; Serotonin ; Suicidal Ideation

No abstract available.
Adult ; Humans ; Male

Inflammatory myofibroblastic tumor (IMT) is a space occupying lesion which is composed of myofibroblasts, plasma cells, and lymphocytes. IMT of the maxillary sinus is rare and its etiology is unknown. We present a case of inflammatory myofibroblastic tumor occurring in the right maxillary sinus of a 57-year-old woman. Radiologically, this tumor was interpreted as malignant neoplasm. On histologic examination, bundles of spindle cells were admixed with inflammatory cells including mature plasma cells and lymphocytes. On the basis of the immunohistochemical findings and ultrastructural features, we recognized that the intervening spindle cells were myofibroblasts. We discussed etiology and prognostic factors of this tumor.
Female ; Humans ; Lymphocytes ; Maxillary Sinus* ; Middle Aged ; Myofibroblasts* ; Plasma Cells