A 6-year-old boy with porokeratotic eccrine ostial and dermal duct nevus on the left sole is reported. The patient was born with keratotic plugs, each measuring 1-2 mm in diameter, on the left sole. Light-microscopic examination revealed epidermal invagination and cornoid lamella, which was found to be connected with hyperplastic intraepidermal and dermal eccrine duct. The present case can be histologically differentiated from nevus comedonicus and punctate porokeratotis.
Child ; Humans ; Male ; Nevus*

Acquired nasolacrimal duct obstruction may result from chronic infection, lacrimal stones, anatomical variations such as aberrant ethmoid cells, facial fractures, or complications following nasal surgery. In Korea, there has been no reported case of secondary nasolacrimal duct obstruction due to a retention cyst in the lacrimal sac. Recently, the authors encountered a 65-year-old female patient who presented with epiphora, was diagnosed with a lacrimal sac retention cyst, and was successfully treated with endoscopic marsupialization.

Anomalous origin of coronary artery is a relatively rare disordes which is often associated with hypertension and valvular geart desease and in some instances lead to sudden death.Among 1,100 patients who underwent diagnosis coronary angiography at Yonsei Uiversity Medical Center, severance hospital, we found 2 patients with anomalous aortic origin of coronary arteries.In one patient, single coronary artery originated from ascending aorta 1.5cm above the left aortic sinus and in another patient, the origin of the orifice of the right coronary artery separately from the left aortic sinus.
Aorta ; Coronary Angiography ; Coronary Vessels* ; Diagnosis ; Humans ; Hypertension ; Sinus of Valsalva

BACKGROUND: Quyyumi et al described circadian variation of ischemic eletrocardio-graphic changes and heart rate in patients with and without significant coronary disease in 1985. Rocco et al also described circadian variation of transient myocaldial ischemia in patients with coronary artery disease. They also noted an increse in ischemic eletrocardiographic abnormalities in the morning hours.In recent years the important of circadian variation of cardiovascular phenomena has generated a great deal of interest. Such phonomena include the occurrence of ischemia in patients with both chronic stable angina and variant angina, myocaldial infarction, sudden cardiac death, ventricular arrhythmia and platelet aggregability. METHOD: To examine whether a significant circadain variation of transient myocardial ischemia exists and to better understand the character of such variation, 35 patients with againa pectoris(15 patients treated with nitrate and/or caclcum channel blocker and 20 patients without treatment) underwent 24 hours ambulatory monitoring of ischemic ST segment changes during daily life. RESULT: Only 21% of the episodes of ST depression were accompanied by chest pain. While 79% were asymptomatic. A significant circadian increase in ischemic activity was found with 44% of episodes and 40% of total ischemic time in not treated group, and 52% of episodes and 56% of total ischemic time in treated group, occuring between 6 A.M. to 12 P.M.(P<0.05 respectively) When the distribution of ischemic episodes was corrected for the variable time of waking, the peak ischemic activity was occuring in the 1st and 2nd hours after rising. There were no significant differences in heart rate at onset and heart rate at 1 min before onset. CONCLUSION: Is summary, transient myocardial ischemia in the absence of pain was more common and there were a significant circadian variation of transient myocardial ischemia with peak activity in the morning. In addition most of transient myocardial were not preceded by a rise in heart rate.
Angina, Stable ; Arrhythmias, Cardiac ; Blood Platelets ; Chest Pain ; Coronary Artery Disease ; Coronary Disease ; Death, Sudden, Cardiac ; Depression ; Heart Rate ; Humans ; Infarction ; Ischemia ; Monitoring, Ambulatory ; Myocardial Ischemia*

PURPOSE: In order to overcome the limitations of the conventional cryopreserved fibroblast or keratinocyte allograft method used in the treatment of diabetic foot ulcers, we reported a pilot study in 2004 demonstrating promising results of a fresh fibroblast allograft method in eight patients. However, the number of cases was insufficient for full evaluation and the follow-up duration was not long enough to determine the efficacy and safety of the method. This encouraged us to conduct this follow-up study to fully evaluate the use of noncryopreserved fresh human fibroblast allografts in treating diabetic foot ulcers. METHODS: Thirty-seven patients with diabetic foot ulcers were treated using fresh fibroblast allografts. Human dermal fibroblasts from healthy teenagers were cultured in DMEM/F-12 medium supplemented with 10% serum. The cultured cells were applied on the wounds immediately following debridement, with fibrin being used as a cell carrier. In eight weeks, percentages of complete healing, mean healing time, and patient satisfactions were assessed, with follow-up time ranging from 6 to 40 months. RESULTS: Our study showed that 83.8% of the treated patients were complete healed. The time required for complete healing was 30.9+/-10.1 days. Patient satisfaction scores for the experimental treatment were higher than those for the conventional method(mean scores of 8.1+/-1.1 and 4.8+/-1.4, respectively). No adverse events related to the study treatment occurred. CONCLUSION: The use of fresh human fibroblast allografts was found to be a safe and effective treatment for diabetic foot ulcers.
Adolescent ; Cells, Cultured ; Debridement ; Diabetic Foot ; Fibrin ; Fibroblasts ; Follow-Up Studies ; Humans ; Keratinocytes ; Patient Satisfaction ; Pilot Projects ; Transplantation, Homologous ; Ulcer

PURPOSE: To better understand visual disabilities via preventative health examination, health behavior, and psychological health. METHODS: The preventative health examination, health behavior, and psychological health records of 4,724 participants over the age of 40 who completed the third Korean National Health and Nutrition Examination Survey (KNHANES III) were analyzed. The participants were divided into 3 groups for analysis: subjects without disabilities, subjects with disabilities but without visual disabilities, and subjects with visual disabilities. The unadjusted mean and the adjusted mean for which socioeconomic factors were adjusted were calculated. RESULTS: In the preventative health examination there were no differences between the 3 groups except for a statistically significant increase in the number of cholesterol check-ups in the visual disability group. In the health-related behavior analysis, lifetime smoking and routine physical activity were similar between the visual disability and no disability group, however, these factors were greater in the disability without visual disability group. The analysis of psychological health revealed that major depressive symptoms, suicidal ideation, suicidal attempts and psychological consultations were greater in the disability without visual disability and the visual disability groups compared to the participants without disability. However the overall number of psychological consultations was low. CONCLUSIONS: There was no difference in the frequency of preventative health examinations between each group. However, there was an increase in the prevalence of psychological problems in subjects with visual disabilities compared to subjects without disabilities and subjects with disabilities but without visual disabilities. Thus, ophthalmologists should consider psychological aspects when dealing with patients with visual disturbances.
Cholesterol ; Depression ; Health Behavior ; Humans ; Motor Activity ; Nutrition Surveys ; Prevalence ; Referral and Consultation ; Smoke ; Smoking ; Socioeconomic Factors ; Suicidal Ideation

PURPOSE: To better understand visual disabilities via preventative health examination, health behavior, and psychological health. METHODS: The preventative health examination, health behavior, and psychological health records of 4,724 participants over the age of 40 who completed the third Korean National Health and Nutrition Examination Survey (KNHANES III) were analyzed. The participants were divided into 3 groups for analysis: subjects without disabilities, subjects with disabilities but without visual disabilities, and subjects with visual disabilities. The unadjusted mean and the adjusted mean for which socioeconomic factors were adjusted were calculated. RESULTS: In the preventative health examination there were no differences between the 3 groups except for a statistically significant increase in the number of cholesterol check-ups in the visual disability group. In the health-related behavior analysis, lifetime smoking and routine physical activity were similar between the visual disability and no disability group, however, these factors were greater in the disability without visual disability group. The analysis of psychological health revealed that major depressive symptoms, suicidal ideation, suicidal attempts and psychological consultations were greater in the disability without visual disability and the visual disability groups compared to the participants without disability. However the overall number of psychological consultations was low. CONCLUSIONS: There was no difference in the frequency of preventative health examinations between each group. However, there was an increase in the prevalence of psychological problems in subjects with visual disabilities compared to subjects without disabilities and subjects with disabilities but without visual disabilities. Thus, ophthalmologists should consider psychological aspects when dealing with patients with visual disturbances.
Cholesterol ; Depression ; Health Behavior ; Humans ; Motor Activity ; Nutrition Surveys ; Prevalence ; Referral and Consultation ; Smoke ; Smoking ; Socioeconomic Factors ; Suicidal Ideation

Recently the Korean Neonatal Network (KNN) was established in order to enhance treatment outcomes further through the registration of very-low-birth-weight infants (VLBWI) data. The present study was conducted on 2,606 VLBWI, 2,386 registered and 220 un-registered, in the KNN participating centers, with the objective of reporting on recent survival rates of VLBWI in Korea and verifying the changing trends in survival rates with data from the 1960s and beyond. The study also aimed to compare the premature infants' survival rate in Korea with those reported in neonatal networks of other countries. The recent survival rate of VLBWI increased more than twice from 35.6% in the 1960s to 84.8%, and the survival rate of the extremely low birth weight infants (ELBWI) increased by more than 10 times, indicating improvement of the survival rate in premature infants with lower birth weight and gestational age. Comparison of VLBWI between countries showed improved survival rates according to each birth weight group in Canada, Australia-New Zealand, and European countries with Japan at the head, but in terms of comparison based on gestational age, differences, except for Japan, have been reduced. Efforts to increase the survival rate of premature infants in Korea with low birth rate are inevitable, and they should be the foundation of academic and clinical development based on its network with advanced countries.
Databases, Factual ; Europe ; Gestational Age ; Humans ; Infant ; Infant Mortality/*trends ; Infant, Extremely Low Birth Weight ; Infant, Newborn ; Infant, Premature ; *Infant, Very Low Birth Weight ; Japan ; Republic of Korea

No abstract available.
Echocardiography, Transesophageal*

Cavovarus deformity is considered an anatomical risk factor for chronic lateral ankle instability (CLAI). However, subtle deformity can be difficult to detect, and its correction is controversial. The current study aimed to evaluate clinical and radiographic outcomes of a modified Broström procedure (MBP) with additional procedures for CLAI with subtle cavovarus deformity and a positive peek-a-boo heel sign. We reviewed the records of 15 patients who underwent MBP with additional procedures for CLAI with a positive peek-a-boo heel sign between August 2009 and April 2015. Consecutive physical and radiographic examinations were performed. The visual analog scale (VAS) for pain, the American Orthopedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, and the Karlsson-Peterson (KP) ankle score were applied to assess clinical outcomes. Weight bearing radiographs, hindfoot alignment view, and ankle stress radiographs were also examined. The mean follow-up period was 58.5 months. Calcaneal lateral closing wedge osteotomy was performed in seven patients to correct fixed hindfoot varus, and first metatarsal dorsiflexion osteotomy was performed in 11 patients to correct plantarflexion of the first ray. Three patients underwent both procedures. Mean VAS, AOFAS, and KP ankle scores improved significantly (p=0.001), and instability did not recur. Radiographically, all stress parameters improved significantly (p=0.007). Simultaneous correction of a positive peek-a-boo heel sign and cavovarus deformity with MBP for CLAI improves clinical outcomes and prevents recurrent instability. A comprehensive evaluation and cautious approach for subtle cavovarus deformity should be followed when treating patients with CLAI. This trial is registered on Clinical Research Information Service (CRiS, KCT0003287).