We successfully transplanted kidney of mother to 13 year old boy who had been suffered from chronic renal failure for 11 months. This is the first case of renal transplantation in childhood in Korea. Patient was treated chronic renal failure with peritoneal dialysis, hemodalysis and transfusion duing 1 month before transplantation. Both kidneys revealed grade 4 vesico-ureteral renal tissue by open wedge biopsy. Patient was transplantated kidney of mother, as the result of HLA antigen tissue type matching. Level of hemoglobin, serum BUN and creatinine were returned to normal after transplantation. Azathioprine and prednisone were used as immunosuppresive agents for 7 months after transplantation. Methylprednisolone was used for 3 days after transplantation. Patient has been followed up at OPD with good condition for 7 months after transplantation.
Adolescent ; Azathioprine ; Biopsy ; Creatinine ; Humans ; Kidney ; Kidney Failure, Chronic ; Kidney Transplantation ; Korea* ; Male ; Methylprednisolone ; Mothers ; Peritoneal Dialysis ; Prednisone

PURPOSE: This study was undertaken to retrospectively evaluate white blood cell kinetics, especially lymphocyte depression after different treatments, and to find the correlation between immunosuppression and large blood volume and dynamic blood flow within the mediastinal radiotherapy (RT) field in lung cancer. MATERIALS AND METHODS: Thirty-four patients with lung cancer were retrospectively evaluated; 10 patients had only radiotherapy (RT group), 8 had chemotherapy (CT group) and 16 had chemotherapy and radiotherapy (RT/CT group). The mean follow-up periods of the RT-including groups (RT group and RT/CT group) and the RT-excluding group (CT group) were 6 and 8 months, respectively. Complete blood cell counts including lymphocyte percentage (%) were checked weekly during RT but less frequently during CT and after RT. RESULTS: Changes in total white blood cell counts were not significantly different among the three groups. The lymphocyte count and lymphocyte % were much lower in the RT-including groups than in the RT- excluding group. The difference between pre-treatment and final lymphocyte count and the difference between pre-treatment and final lymphocyte % were significant (p=0.044 and p=0.037) between the RT- including groups and the RT-excluding group. CONCLUSION: Lymphopenia was more marked after treatment containing RT than CT only. Lymphopenia may be one cause of a compromised immune system after mediastinal irradiation in lung cancer. We suggest cautiously that previous studies showing evidence of lymphocyte apoptosis after low-dose irradiation and large blood volume and dynamic blood flow within the RT fields could be somewhat related to lymphopenia after mediastinal irradiation.
Apoptosis ; Blood Cell Count ; Blood Volume ; Depression ; Drug Therapy ; Follow-Up Studies ; Humans ; Immune System ; Immunosuppression ; Kinetics ; Leukocyte Count ; Leukocytes ; Lung Neoplasms* ; Lung* ; Lymphocyte Count ; Lymphocytes ; Lymphopenia* ; Radiotherapy ; Retrospective Studies