BACKGROUND: The 5α-reductase inhibitor finasteride blocks the conversion of testosterone to dihydrotestosterone(DHT), the androgen responsible for androgen- etic alopecia in genetically predisposed men. OBJECTIVE: The purpose of this study was to determine the efficacy of finaster- ide treatment according to the type of androgenetic alopecia in Korea. METHODS: 196 patients with finasteride(1.25mg/day) were registered in this study and 68 patients were followed over 8 months. Efficacy was evaluated by globa1 photographs, investigator assessment of clinical change,and patients' self assessment via self administered hair growth questionnaire. RESULTS: Patients' self-assessment demonstrated that finasteride treatment slowed hair loss, increased hair growth, and improved appearance of hair. These improvements were corroborated by objective assessments after 4 months of treatment. Adverse effects such as sexual dysfunction were minimal. CONCLUSION: Oral finasteride 1.25mg/day slowed the progression of hair loss and increased hair growth in clinical tria1s of men with androgenetic alopecia over 8 months. With its generally good tolerability profile, finasteride is a new approach to the management of this condition, for which treatment options are few.
Alopecia* ; Finasteride* ; Hair ; Humans ; Korea ; Male ; Research Personnel ; Self-Assessment ; Testosterone

Sixty six Colles' fracture were treated with radial slab or U-cast (sugar tong splint), from January 1982 through May 1984 at the Department of Orthopaedic Surgery of St. Mary Hospital. A prospective study was made and was evaluated under the subjective criteria of Gartland and Werley, and the objective criteria of Scheck. The results of this study were as follows: 1. All of 66 cases was closed fracture and the incidence was high in females who aged over 6thdecades. 2. In 43 cases of stable fracture, 18 (94.7 %) out of 19 cases treated with radial slab and 21 (87.5%) out of 24 cases treated with U-cast showed satisfactory result. 3. In 23 cases of unstable fracture, 6 (54.6%) out of 11 cases treated with radial slab and 9 (75%) out of 12 cases treated with U-cast showed satisfatory result. 4. As a result, we found that the result of the treatment with radial slab was superior to the U-cast for the stable Colles fracture, however, all of two methods were not staisfatory for the unstable Colles fracture although the U-cast group showed better result.
Colles' Fracture ; Female ; Fractures, Closed ; Humans ; Incidence ; Prospective Studies

No abstract available.
Proteinuria*

This study was undertaken to elucidate any quantitative abnormalities of Tlymphocyte subsets (helper/inducer T cell; T cell and suppressor/cytotoxic T cell: T cell) and IgE levels in the peripheraI blood in atopic dermatitis patients by using monoclonal antibodies and enzyme immunoassay, respectively. In addition we have tried to ascertain whether there are any correlations betveen such immuiiologic abnormalities and the severity of the disease. The results showed that there were significant decrease in the mean percentage of T Cells and increase in the mean value of T/T cell ratios in patients with atopic dermatitis. These changes seem to relate to the severity of the disease when evaluated as groups. A significant increase in the mean value of serum IgE was found in atopic dermatitis patients and the change was related to the severity of the disease. But increase of serum IgE level did not correlated closely with the T cell abnormalities in each patients.
Antibodies, Monoclonal ; Dermatitis, Atopic* ; Humans ; Immunoenzyme Techniques ; Immunoglobulin E* ; T-Lymphocyte Subsets* ; T-Lymphocytes

The present study was designed to measure the activity of purine nucleoside phosphorylalse (PNPase) in sera, erythrocytes and lymphocytes of blood from patients with various dermatoses as it's activities are known to be decreased in cell-mediated immune deficiency diseases. The PNPase activities in sera, erythrocytes and lymphocytes of normal subjects were (3. 9+1. 03) x 104 unit/L, 5.04+1. 06 unit/107rbc, l. 74+0. 35 unit/103 lymphocytes respectively. In urticaria, leukocytoclastic vasculitis and purpura, there were no differences in PNPase antivities between patients groups and normal subjects. In atopic dermatitis, there were no differences in PNPase activities of sera and erythrocytes between patients group and normal subjects. But, lymphocyte PNPase activities of atopic patients were lowered than those of normal subjects(1.41 +0. 52 unit/10 lymphocytes). In tuberculoid leprosy, there were no differences in lymphocyte PNPase activities between patients group and normal subjects. But, the PNPase activities in sera and erythrocytes of patients group were lowered than those of normal subjects (3. 20. 76) x 104 unit/L, 3. 8n+1.96 unit/107rbc). The PNPase activities in sera((l. 87+/-0. 62) x 104 unit/L), erythrocytes(2. 08+0. 98 unit/107rbc) and lymphocytes (0.51+0. 26 unit/103 lymphocytes) of lepromatous leprosy patients were significantly lowered than those of normal subjects.
Deficiency Diseases ; Dermatitis, Atopic ; Erythrocytes* ; Humans ; Leprosy, Lepromatous ; Leprosy, Tuberculoid ; Lymphocytes* ; Purine-Nucleoside Phosphorylase* ; Purpura ; Skin Diseases* ; Urticaria ; Vasculitis

No abstract available.
Humans ; Rhinitis* ; Skin Tests* ; Skin*

No abstract available.
Hernia* ; Pneumoperitoneum*

OBJECTIVE: It has been reported that the sleep apnea syndrome in the asthmatic patients is prevalent, however, the systematic study in this field using polysomnography has rarely been performed. The aim of this study is to investigate the relationship between the apnea-hypopnea index (AHI) and the pulmonary function in asthmatic children. METHODS: This study enrolled 19 male and 12 female asthmatic children aged 6-13 years (average 8.2+/-1.7 years old). Complete overnight polysomnography and pulmonary function test were performed for the participants. RESULTS: Of the 31 asthmatic children, 21 (67.7%) met the diagnostic criteria of the pediatric sleep apnea and the average AHI was 1.7+/-1.5/h. The children with higher AHI showed poorer pulmonary function (FEV1/FVC ratio : p=0.002, FEV1%pred : p=0.047). CONCLUSION: These results suggest that the prevalence of the pediatric sleep apnea could be very high among the asthmatic children and the severity of the sleep apnea correlates with the pulmonary function. However, the case-control study to compare the AHI between the asthma and control groups is absolutely necessary because few normative data are available for the children.
Aged ; Asthma ; Case-Control Studies ; Child ; Female ; Humans ; Male ; Polysomnography ; Prevalence ; Respiratory Function Tests ; Sleep Apnea Syndromes

No abstract available.
Pierre Robin Syndrome*

No abstract available.
Neck*