Angiogenesis, the induction of new capillaries and venules, is associated with tumor growth. This study was designed to determine whether cervical carcinomas are angiogenic, and to investigate whether tumor angiogenesis can serve as a prognostic factor in cervical carcinoma. Surgical specimens of 47 cervical carcinomas were immunohistochemically stained specifically for endothelial cells with factor VIII-related antigen to identify all vessels. Microvessels were counted from photographs of 200x microscopic fields. In addition, thirty-seven cases were studied by immunohistochemical means using the monoclonal antibodies for PCNA and for Ki-67 to determine tumor cell proliferation rates in cervical carcinomas. The microvessel count(MVC), the PCNA labelling index, and the Ki-67 index were calculated and compared with known prognostic factors and disease free survival rates in cervical carcinomas. A wide range in the MVC count(range 12-100 mean=38.2+/-19.2), the PCNA labeling index(8-69% mean=33.6+/-15.2%), and in the extent of Ki-67 staining(0-43% mean=10.3+/-10.5%) was observed, indicating considerable variation of tumor angiogenic activity and tumor growth rates. This study showed statistically significant correlations in disease free survival rates with both lymph node status and the microvessel count. However, there was no significant difference in disease free survival rates between tumor stage, age, the PCNA labelling index, and the Ki-67 index.
Antibodies, Monoclonal ; Capillaries ; Cell Proliferation ; Cervix Uteri* ; Disease-Free Survival ; Endothelial Cells ; Female ; Lymph Nodes ; Microvessels ; Proliferating Cell Nuclear Antigen ; Venules ; von Willebrand Factor

Internal hernia is an unusual cause of the intestinal obstruction. The advances of CT make the diagnosis more easier than in the past. We report one case of internal hernia with herniation of the ileum into the lesser omenturn. The diagnosis could be made when abdominal radiographs showed fixed clustering of the small bowel loops in upper abdomen medial to the stomach. CT and ultrasound showed characteristic interposition of the ileum between the left hepatic lobe and the stomach.
Abdomen ; Diagnosis ; Hernia* ; Ileum ; Intestinal Obstruction ; Stomach ; Ultrasonography

Intravascular papillary endothelial hyperplasia is a benign solitary turnor that may be histologically misdiagnosed as angiosarcoma. We present herein a case of intravascular papillary endothelial hyperplasia occuring in 40-year-old female who hsd a slowly growing tumor on the tongue for 3 years. the histopathologic findings revealed. papillary endothelial hyperplasia in blood vessel accompanied with thrombi.
Adult ; Blood Vessels ; Female ; Hemangiosarcoma ; Humans ; Hyperplasia* ; Tongue*

We reviewed two cases of keratosis punctata palmaris et plantaris(KPP) and the scanning electron microscopic findings(SEM). The skin lesions of KPP are multiple, hyperkeratotic on the palms and soles with central pitting. There was no subjective symptoms. The histologic findigs revea,l marked hyperkeratosis, hypergranulosis, and acanthosis with depression of the underlying malpighian layers. The SEM findings reveal one hyperkeratoic plug on punctate lesion(case I ) and three hyperkeratotic plugs on depression of the malpighian layer(case ll ).
Depression ; Keratoderma, Palmoplantar* ; Keratosis* ; Skin

The eruptive collagenoma is a connective tissue nevus without family history. We report a case of eruptive collagenoma in a 5 year old boy, who had multiple, variable sized orange colored nodules on his back since birth. The histopathologic finding showed increased number and size of collagen fiber and increased dermal thickness.
Child, Preschool ; Citrus sinensis ; Collagen ; Connective Tissue ; Humans ; Male ; Nevus ; Parturition

PURPOSE: The purpose of this study is to assess the sonographic findings of Osgood-Schlatter disease with correlation to radiographic findings and to determine value of sonography in the diagnosis of Osgood-Schlatter disease. MATERIALS AND METHODS: The population consist of 22 cases of Osgood-Schlatter disease and 15 healthy subjects of the same age range for comparison. The sonographic study was carried out with real time units equipped with linear probe of 7 MHz frequency. Radiography and sonography were done in all cases and follow-up sonography was performed in 10 cases. RESULTS: The sonographic features of the Osgood-Schlatter disease were swelling of cartilage over the anterior tibial tuberosity ossification center in 16 cases, fragmentation and/or irregularities of the ossification center of the anterior tibial tuberosity in 14 cases, localized thickening of the pateliar tendon in 14 cases, ossicles in the thickened pateliar tendon in 3 cases, and distension of the infrapatellar bursa in 2 cases. Fifteen of 22 cases of Osgood-Schlatter disease had abnormal findings on radiographs and sonograms. Out of 7 cases which had normal radiograph and abnormal findings on sonogram, 6 cases showed pateliar tendon thickening, cartilage swelling, and/or distended infrapatellar bursa and one case showed fragmentation of anterior tibial tuberosity on sonogram. CONCLUSION: Sonographic evaluation of Osgood-Schlatter disease provided a clear picture about pathologic changes in the superficial soft tissues and in the cartilage and also yielded the same diagnostic information on bony change as radiography Sonography is a reliable and useful method for the evaluation of young patients with clinically suspected Osgood-Schlatter disease.
Cartilage ; Diagnosis* ; Follow-Up Studies ; Humans ; Osteochondrosis* ; Radiography ; Tendons ; Ultrasonography*

PURPOSE: The purpose of this study is to assess the sonographic findings of Osgood-Schlatter disease with correlation to radiographic findings and to determine value of sonography in the diagnosis of Osgood-Schlatter disease. MATERIALS AND METHODS: The population consist of 22 cases of Osgood-Schlatter disease and 15 healthy subjects of the same age range for comparison. The sonographic study was carried out with real time units equipped with linear probe of 7 MHz frequency. Radiography and sonography were done in all cases and follow-up sonography was performed in 10 cases. RESULTS: The sonographic features of the Osgood-Schlatter disease were swelling of cartilage over the anterior tibial tuberosity ossification center in 16 cases, fragmentation and/or irregularities of the ossification center of the anterior tibial tuberosity in 14 cases, localized thickening of the pateliar tendon in 14 cases, ossicles in the thickened pateliar tendon in 3 cases, and distension of the infrapatellar bursa in 2 cases. Fifteen of 22 cases of Osgood-Schlatter disease had abnormal findings on radiographs and sonograms. Out of 7 cases which had normal radiograph and abnormal findings on sonogram, 6 cases showed pateliar tendon thickening, cartilage swelling, and/or distended infrapatellar bursa and one case showed fragmentation of anterior tibial tuberosity on sonogram. CONCLUSION: Sonographic evaluation of Osgood-Schlatter disease provided a clear picture about pathologic changes in the superficial soft tissues and in the cartilage and also yielded the same diagnostic information on bony change as radiography Sonography is a reliable and useful method for the evaluation of young patients with clinically suspected Osgood-Schlatter disease.
Cartilage ; Diagnosis* ; Follow-Up Studies ; Humans ; Osteochondrosis* ; Radiography ; Tendons ; Ultrasonography*

For the purpose of epidemiologic study, the patients who visited Severance Hospital Behcet's Syndrome Specialty Clinic were grouped by Shimizu classification into the complete, incomplete, suspected types and evaluated. The results of the evaluation with respect to personal characteristics, geographic distribution, socioeconomic characteristics, family history, and clinical characteristics are as follows. 1. The incidence among the subgroups was incomplete type(46.3%), suspected type(36.7%), complete type(17.0%) and the male to female ratio was 0.60: 1, and the average age of onset was 29.1. years for males and 27.6 years for females. 2. The occupational distribution among males included office workers, 31.5%; drivers, 10.6% and among females was office workers, 6.7%; teachers, 3. 7 %; unemployed, 81.7%. 3. Among the presumed aggrevating factors affecting oral cavity, recurrent tonsillitis(20.8%) was most common, and premenstrual exacervation(12.8%) was most common. 4. The most common initial major manifestation was oral ulcer(80.6%), and the longest duration of major manifestations was oral ulcer(average 6.4 years), and the most frequent relapse of major manifestations was oral ulcer(average 14.6 times/year). 5. The average duration between the appearance of the first and second major manifestations was 5.2 years for complete type, 6.3 years for incomplete type, and 6.6 years for suspected type. 6. Combinations of major manifestations most commonly included oral ulcer, genital ulcers and skin lesions(65.3%) for incomplete type, and oral ulcer, skin lesion(54.8%) for suspected type.
Age of Onset ; Behcet Syndrome* ; Classification ; Epidemiologic Studies ; Family Characteristics ; Female ; Humans ; Incidence ; Male ; Mouth ; Oral Ulcer ; Recurrence ; Skin ; Ulcer

Implantation is a cascade of process which fertilized conceptal tissue move into maternalendometrium. Recently, with development of life science, the informations about humanimplantation process have been important topic with regard to the reproductive medicaltechnology. However, the precise mechanism and the factors involved in the process is notclearly understood, because the human experiments have been inhibited due to ethical andreligious views to the point. To study the human implantation process, we develop the modelto culture the human endometrium and trophoblast in vitro. The microscopic findings ofcultured monolayer of endometrial glandular epithelium and stroma in respond to co-culturedtrophoblast cells were observed. As results, trophoblasts didn't change the microscopicmorphology of endometrial glandular layer. However, trophoblast cells destructed the higherconcentration of epidermal growth factor in culture media. These results suggests thatepidermal growth factor may be a important factor for trophoblast invasion to stromal layerand trophoblast may invade the glandular layer by different mechanism to endometrial stroma.
Biological Science Disciplines ; Culture Media ; Endometrium ; Epidermal Growth Factor ; Epithelium ; Female ; Humans* ; Trophoblasts*

The purpose of this study was to compare the difference of two survey methods for health services research. Data were collected by means of two types of household survey conducted from March 11 to September 19, 1985. A probability sample of 30,613 persons was taken from 180 Enumerated Districts designated by the Economic Planning Board. The sample was divided into two groups systematically. One group was surveyed by the self-administered questionnaire and the other group was interviewed. Response rates were 81.4% and 90.6% respectively. The data were analyzed by the ratio of the results of the self-administered survey to those of the interview survey. No difference was observed in sex, age, residence, or occupation between the two groups. However the respondents' characteristics were statistically different between the two groups. The major findings of this study are as follows : 1. The morbidity rate was 142.5 per 1,000 persons during the two week period by the self-administered questionnaire survey and 74.3 per 1,000 persons with the interview survey method. The ratio of the morbidity rate by the self-administered questionnaire to that by the interview was 1.92, and the difference between the two rates were due to the personal characteristics. 2. The out-patient utilization rate was 10.2 visits per person per year by the self-administered questionnaire survey and 5.4 by the interview survey, and the ratio was 1.89; the admission rate was 3.2 times per 100 persons per year by the self-administered questionnaire survey and 1.9 times by the interview survey, and the ratio was 1.68. Differences due to the sociodemographic characteristics were greater in the out-patient utilization rates than in the admission rates. 3. Percentages of effective medical care demand were 90.2% in the self-administered survey and 92.3% in the interview survey; the ratio was 0.98 which was less than that of the morbidity rate and medical care utilization. But, differences of effective medical care demand occurred in persons with no occupation, and aged or low educated respondents. 4. Respiratory illness had the highest frequency in the two survey methods. But there was a slight difference between the two survey methods in morbidity composition. 5. It was concluded that data collected by the interview survey were inclined to be underestimated and this problem can be corrected by a modified self-administered survey.
Surveys and Questionnaires* ; Family Characteristics ; Health Services Research* ; Health Services* ; Humans ; Occupations ; Outpatients ; Surveys and Questionnaires* ; Sampling Studies