BACKGROUND: Ciclopiroxole.minsolution or cream is the topical in imycotic agent which has been known to have the ability to penetrate the horny skin and nail keratin. OBJECTIVES: The purpose of this study was to evaluate the pierapeutic effect of 1% ciclopiroxolamine solution on onychomycosis. METHODS: 1% ciclopiroxolamie solution was applied topically to hentire surface of t,he diseased nail at least twice a day for 12 to 36 weeks according to the verity of nail involvement and degree of improvement in 21 cases of onychomycoses. RESULTS: 1. With only topical application of 1% ciclopiroxolamine solutior, 4 out of 21 cases(67%) showed 25% or more reduction of the affected nail area, and 8 out of 21 cases(38%) showed 50% or more reduction of the affected nail area. 2. There was no significant difference in the degree of improvem of according to the duration of disease. 3. Therapeutic effect was relat.ively high on Candida albicans, while it was relatively low on Aspergillus species. 4. 3 out of 7 cases of mild(up to 30%) involvement showed a 7% or more reduction of the affected nail, while 4 out of 6 cases of severe(60-100%) involvement showed a 25% or less reduction of the affected nail. 5. As side effects during the topical application of 1% ciclopiroxol nr ne solution, periungualer ythema appeared in 3 cases, and a burning sensation in 4 of 21 cases. CONCLUSION: 1% ciclopiroir olaniine solution could be tried as an effctive therapeutic agent on onychomycosis for the patient who would not be tolerable to oral an ifiigal medication for associated systemic diseases or who does not want oral medication.
Aspergillus ; Burns ; Candida albicans ; Humans ; Onychomycosis* ; Sensation ; Skin

Herpes zoster is characterized by several groups of vesicles situateu unilaterally within the distribution of the cranial or spinal nerve coming from one posterior ganglion Biateral involvement and recurrence are rare, and zoster involves two widely separated regions at on time are even rarer. We report a case of bilateral eupes zoster. A 5-years-old female patient was presented with painful bilateral grouped vesicles on an erythematous base along the dermatome of Lt T2 and Rt T5. Tzanck smear revealed multinucleated giant cells, and histopathologic findings were consistent with herpetic infection. She was successfully treated by administration of acyclovir without any significant cornplications.
Acyclovir ; Female ; Ganglion Cysts ; Giant Cells ; Herpes Zoster* ; Humans ; Recurrence ; Spinal Nerves

BACKGROUND: Squamous cell carcinoma(SCC) is the most common skin cancer in Korea and its incidence is increasing. OBJECTIVE: Our purpose was to evaluate the clinical and histopathological characteristics of SCC. METHODS: Forty cases of cutaneous SCC slides were retrieved from the files of the surgical pathology division of the National Medical Center. Hematoxylin and eosin stained sections were re-examined microscopically by two dermatologists independently. For the cases of reconfirmed SCC, clinical characteristics including incidence, age and sex distribution, location and underlying conditions and histopathologic grading by Broder's grade system were evaluated. For 3 control cases controls and 17 cases of the SCCs, cytokeratin expression patterns on immunohistochernical staining using monoclonal antithodies MNF 116, RCK 102 and NCL 5D3 were observed. RESULTS: 1. Of 40 specimens, 33 specimens(73.3%) were histologically reconfirmed as true cutaneous SCCs. 2. The most commonly involved age group was the fifth decade of life and the median age when diagnosis was made was 57.3. 24 male patients and 9 female patients were involved and the ratio of male to female was 2.67: 1. 3. Most commonly involved sites were face and lower extremities and the incidence of occurrence on sun exposed areas increased in accordance with an increase of the age. 4. Underlying conditions such as burn scars, osteomyelitis or atomic bomb exposure were associated in 455% of SCCs. 5. Histopathologic grading of 33 cases of SCCs by Broder's grade was performed as follows.:23 cases(67.7%) of grade I, 8 cases(24.2%) of grade II and 2 cases(6.1%) of grade III. 6. The cytokeratin expressio pattern on immunohistochemical staining for 3 of the control cases and 17 cases of SCCs showed some differences between the highly and poorly differentiated groups of SCCs. CONCLUSION: We evaluated the clinical and histopathological characteristics of primary cutaneous SCCs in the National Medical Center from september 1978 to August 1993.
Burns ; Carcinoma, Squamous Cell* ; Cicatrix ; Diagnosis ; Eosine Yellowish-(YS) ; Female ; Hematoxylin ; Humans ; Incidence ; Keratins ; Korea ; Lower Extremity ; Male ; Nuclear Weapons ; Osteomyelitis ; Pathology, Surgical ; Sex Distribution ; Skin Neoplasms ; Solar System

We report a case of a 53-year-old woman with squamous cell carcinoma with lymph node metastasis who has had a recurrent painful bleeding papule on the right toe nail bed with resultant nail plate shedding over the past two years. X-ray and computer tomography examinations showed nearly total destruction of the distal phalanx of the right fifth toe and right inguinal lymph node enlargemet it. A nail bed biopsy specimen disclosed invading tumor masses composed of atypical squamous cells and multiple horn pearls. While squamous cell carcinoma of the nail bed is not usually aggresive and local removal is usually adequate, the possibility that metastasis or invasion of the adjacent phalanx or joint can occur should be kept in mind.
Animals ; Biopsy ; Carcinoma, Squamous Cell* ; Female ; Hemorrhage ; Horns ; Humans ; Joints ; Lymph Nodes* ; Middle Aged ; Neoplasm Metastasis* ; Toes

Background: This study aimed to examine the association between sitting time and handgrip strength in healthy Korean women. Methods: A total of 5,437 participants were included from the Korea National Health and Nutrition Examination Survey 2014–2016. The overall daily sitting time was estimated using health interview surveys, and handgrip strength was assessed using a digital hand dynamometer. The relationship between sitting time and handgrip strength was calculated with a weighted analysis of covariance after adjusting for confounding variables. Results: Participants in each age group (19–39, 40–64, ≥65 years) were divided into three categories according to sitting time: ≤5, 6–9, and ≥10 h/d. The handgrip strength tended to decrease as sitting time increased after adjusting for age, body mass index, alcohol intake, cigarette smoking, resistance exercise, aerobic physical activity, household income, education level, hypertension, diabetes mellitus, dyslipidemia, and depression in all age groups (all P<0.001). Conclusion We observed the inverse relationship between sitting time and handgrip strength in healthy Korean women.

The aim of this in vitro study was to evaluate the cleaning efficacy of various irrigation methods in the mandibular mesial roots. The forty five mesial root canals were shaped by Profile .06 instruments to apical size #30 and irrigated with 5 ml of 3.5% NaOCl. The teeth were divided into 3 groups and irrigated finally for 1 minute; Group 1: syringe irrigation, Group 2: ultrasonic irrigation, Group 3: RinsEndo irrigation. After histological processing, the cross sections of apical 1, 3, and 5 mm level were examined with an optical microscope. The cleanliness values of canals and isthmuses were calculated and analyzed by Mann-Whitney U test. 1. There were no significant differences in both canal and isthmus cleanliness between syringe irrigation and ultrasonic irrigation except 5 mm level of isthmus. 2. RinsEndo irrigation had significantly higher canal cleanliness values than syringe irrigation at 1 mm and 3 mm levels (p < 0.05). Also, RinsEndo irrigation had significantly higher isthmus cleanliness values than syringe irrigation at all levels evaluated (p < 0.05). 3. There were no statistical differences in both canal and isthmus cleanliness between ultrasonic irrigation and RinsEndo irrigation except 3 mm level of canal. From this study, RinsEndo irrigation can be useful as an additional irrigation procedure.
Dental Pulp Cavity ; Molar ; Syringes ; Tooth ; Ultrasonics

Posthemorrhagic hydrocephalus is a major problem in premature infants. We describe our experience with a neonate that was an extremely low birth weight infant with posthemorrhagic hydrocephalus, who was treated by repeated ventricular drainage through an Ommaya reservoir for more than two months until the placement of a ventriculoperitoneal shunt was possible. The Ommaya reservoir served as a bridge to definitive treatment. The patient required sodium supplements due to excessive salt loss from the repeated ventricular drainage procedures. Regular measurement of serum electrolytes in any infant requiring serial ventricular drainage is recommended.
Drainage ; Electrolytes ; Humans ; Hydrocephalus ; Hyponatremia ; Infant ; Infant, Extremely Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Sodium ; Ventriculoperitoneal Shunt

Since the concept of osseointegration has been introduced, a lot of researches were performed to achieve stronger fixation of the implant. In this study, we tried to find the different pattern of bone ingrowth after implanting pure titanium implant and Hydroxyapatite coated titanium implant in dogs. Four typed of cylindrical titanium implants (diameter 6 mm, length 1 mm) were inserted in the distal femur of adult dogs. The histological examination was done at postoperative 2, 4, 8, and 12 weeks. There was no foreign body reaction at contact site and all implants kept direct contact with bone tissue. In the light microscopic finding, after 2 weeks, the cases with Hydroxyapatite-coated Implant (HAP) showed greater formation of immature woven bone in comparison to Titanium implant. After 4 weeks, Hydroxyapatite-coated Implant (HAP) showed more mature lamellar bone. After 8 and 12 weeks, most of the woven bone was transformed into mature lamellar bone. The fluorescence microscopic finding, after 2 weeks, revealed calcein green fluorescence around implants in all cases and it was more prominent in the cases with Hydroxyapatite-coated Implant (HAP). After 4 weeks, the center of trabecula gave out green fluorescent light, the corner of them showed red fluorescent light, and they were more prominent in the cases with Hydroxyapatite-coated Implant (HAP). After 8 and 12 weeks, green fluorescence disappeared gradually, red fluorescence appeared for the most part, and there was no difference in each cases, especially in 12 weeks. As a result, we support the concept that Hydroxyapatite-coated Implant (HAP) induces faster bone ingrowth in 4 weeks than Titanium implant, and that it may be more profitable for early bone ingrowth and implant stability.
Adult ; Animals ; Bone and Bones ; Dogs* ; Durapatite ; Femur ; Fluorescence ; Foreign-Body Reaction ; Humans ; Osseointegration ; Titanium*

Neonatal listeriosis is not uncommon in Western developed countries, and has significant mortality and morbidity. However, its incidence in Asian countries is relatively low and it has rarely been reported in Korea. Once infected, Listeria monocytogenes (L. monocytogenes) can have high mortality and listeriosis in pregnancy may present serious hazards to the fetus and the newborn as sepsis and death through direct infection of the placenta and chorioamnionitis. Because early detection of L. monocytogenes infection is difficult, only high index of suspicion toward this disease can hopefully prompt treatment of this life-threatening perinatal infection. We experienced a case of L. monocytogenes yielded in cultures of blood and amniotic fluid of the newborn and the mother who delivered at 25+1 weeks of gestation because of preterm labor that developed without any specific evidence of infection. We report this case with a brief review of the literature.
Amniotic Fluid ; Asian Continental Ancestry Group ; Chorioamnionitis ; Developed Countries ; Female ; Fetus ; Humans ; Incidence ; Infant, Newborn ; Korea ; Listeria monocytogenes ; Listeriosis ; Mothers ; Obstetric Labor, Premature ; Placenta ; Pregnancy ; Sepsis

BACKGROUND: Recently, in our ageing society, the change in dietary pattern and increase in obesity have caused the metabolic syndrome to increase in Korea. Because of the association of the risk of cardiovascular diseases, the metabolic syndrome must be prevented and well managed. We examined the association between the metabolic syndrome and the serum testosterone and DHEA-S concentration. METHODS: The subject of this study included 231 men aged more than 40 years old who visited the health promotion center of a university hospital from March 2004 to March 2006. We excluded the subjects who were currently on medications except for antihypertensive and hypoglycemic agents. We defined the metabolic syndrome according to the ATP III with Asia-Pacific waist circumference. To examine the association between the metabolic syndrome and the serum testosterone concentration, we used the method of multiple logistic regression analysis. RESULTS: The prevalence of the metabolic syndrome in our subjects was 32.9%. Decreased serum testosterone concentration was significantly associated with large waist circumference and high fasting blood sugar. Men with testosterone values in the upper tertile had a significantly lower risk of metabolic syndrome (OR=0.34, P=0.018). CONCLUSION: After statistical adjustment for age, smoking, income, exercise, alcohol intake, and body mass index, the serum testosterone concentration was negatively associated with the metabolic syndrome.
Adenosine Triphosphate ; Adult ; Blood Glucose ; Body Mass Index ; Cardiovascular Diseases ; Fasting ; Health Promotion ; Humans ; Hypoglycemic Agents ; Korea ; Logistic Models ; Male ; Obesity ; Prevalence ; Smoke ; Smoking ; Testosterone* ; Waist Circumference