PURPOSE:Varying clinical phenotypes are associated with the chromosome 22q11.2 microdeletion syndrome. The endocrine manifestation are latent or overt hypoparathyroidism, thyroid dysfunction and short stature. This study was undertaken to investigate frequencies of endocrine abnormalities and short stature in patients with the chromosome 22q11.2 microdeletion syndrome. METHODS:Forty three unrelated patients were diagnosed having chromosome 22q11.2 microdeletion syndrome. Chromosomal microdeletion was confirmed by fluorescent in situ hybridation (FISH) with DNA probe (22q11.2 LSI TUPLE1 from Vysis). Serum total calcium and intact parathyroid hormone (PTH) were measured in all patients. Thyroid function tests including free thyroxine(T4), thyroid stimulating hormone (TSH) and thyroid autoantibodies were performed in all patients. Insulin-like growth factor-1 (IGF-1) was measured in 10 patients. Height, weight and body mass index were compared with chronological age in all patients. RESULTS:Seven patients (16%) had an overt hypoparathyroidism, presenting with hypocalcemic tetany. Thirteen patients (31%) showing hypocalcemia with normal PTH were regarded as having latent hypoparathyroidism since their PTH secretion response was blunted. Out of 2 patients with thyroid diseases, one patient had Graves disease and the other had Hashimoto thyroiditis. Five patients (12%) were below the 3rd percentile in height at evaluation. The BMI was below the 5th percentile in 23% of patients. CONCLUSION: Twenty patients (47%) presented with overt and latent hypoparathyroidism. Interestingly, autoimmune thyroid diseases such as Graves disease and Hashimoto thyroiditis were associated in patients with chromosome 22q11.2 microdeletion, indicating predisposition to autoimmune disorders. Therefore, a careful endocrine and growth evaluation is needed in these patients.
Autoantibodies ; Body Mass Index ; Calcium ; DNA ; Graves Disease ; Hashimoto Disease ; Humans ; Hypocalcemia ; Hypoparathyroidism ; Parathyroid Hormone ; Phenotype ; Tetany ; Thyroid Diseases ; Thyroid Function Tests ; Thyroid Gland ; Thyrotropin

No abstract available.
Mesenteric Lymphadenitis* ; Yersinia pseudotuberculosis* ; Yersinia*

No abstract available.
Mesenteric Lymphadenitis* ; Yersinia pseudotuberculosis* ; Yersinia*

Choroidal neovascularization, also called subtetinal or subpigment epithelial neovasculariztation, may occur in the absence of any associated disorder and with no known etiology; in such cases, it is designated as idiopathic. Idibpathic chormdal neovascularization is characterized generally by an isolated neovascular membrane in the macula and is usually associated with a serous and/or hemorrhagic detachment of the overlying and adjacent sensory retina. The classic angiographic findings are lacy, nodular, or irregular, hyperfluorescence in the early phase, with pooling of dye in the subsensory retinal space during the late phase. The authors experienced a case of idiopathic choroidal neovascularization. A brief review of literature is described.
Choroid* ; Choroidal Neovascularization* ; Membranes ; Retina ; Retinaldehyde

No abstract available.
Coronary Vessels* ; Fistula*

The surgical release of flexor tendons from their restricting adhesions has historically been a somewhat controversial procedure. Especially clinical efficacy of tenolysis is dependent on early active digital motion. The administration of long acting anesthetics (Bupivacaine) through indwelling catheter after tenolysis relieved pain and so achieved early active digital motion in 12 cases. The times for tenolysis following tendon repair and the followup period were 3 months and 6 months on an average. According to flexor zones classification, in 4 patients the lesion was in zone II, 5 in zone III, 1 in zone IV and 2 in zone V. The results were as follows; 1. The functional results after tenolysis showed up 7 excellent, 4 good and 1 fair. 2. The subjective results of the postoperative pain relief showed up 8 excellent and 4 good out of 12 cases.
Anesthetics ; Catheters, Indwelling ; Classification ; Follow-Up Studies ; Humans ; Pain, Postoperative ; Tendons ; Treatment Outcome

Pharmacia single-piece 700B posterior chamber intraocular ienses (PCL) were implanted on 50 eyes of 48 patients were followed up for three months and the clinical results obtained are as follows. - Postoperative corrected visual acuity recovered to 20/40 or better in 90% of implanted eyes. - Postoperative complications were fibrinous membrane(3 eyes), fibrillar filaments(3 eyes), iris pigments on PCL surface with iritis(6 eyes), sterile hypophyon(1 eyes), cystoid macular edema(1 eye), iris tucking(1 eye), and after cataract(1 eye). - This 700B model looks a less flexibility of haptic loop which has rectangular shape in cross-section and a more curved end portion. We found the characteritic designs should be some modification.
Fibrin ; Humans ; Iris ; Pliability ; Postoperative Complications ; Visual Acuity

Pulmonary function tests were conducted in 60 male adults and 60 female adults at 20~79 years of age. They showed noevidenee of pulmonary disease on clinical symptoms, X-ray finidngs and past history. We wanted to evaluate the deterioration of pulmonary functional reserve in the aged. The results were as follows: 1) In males, FVC decreased significantly (p <0.01) from 4440+/-271.38 ml in 20~29 year-old subjects to 3090+/-445.75 ml 70~79 year-old subjects. The correlation coefficient with age was-0.6846. 2) In females, FVC decreased significantly (p<0.01) from 2097+/-479.42ml in 20~29 year-old subjects to 2142+/-233.13ml in 70~79 year-old subjects The correlation coefficient woth age was 0.6454. 3) In males, FEV, decreased significantly (p<0.01) from 4005+/-268.26 ml in 20~29 year-old subjects to 2373+/-326.36ml in 10~79 year-old subjects. The correlation coefficient with age was-0.8229. 4) In females, FEV1 decreased significantly (p<0.01) from 2586+/-519.00 ml in 20~29 yrar-old subjects to 1645+/-330.36ml in 70~79 year old subjects The correlation coefficient with age was 0.7013. 5) In males, FEV1/FVC decreased significantly (p<0.01) from 90.17+/-4.90% in 20~29 year-old subjects to 76.72+/-8.13% in 70~79 year-old subjects. The correlation coefficient with age was-0.5595. 6) In females, FEV1/FVC decreased significantly (p<0.01) from 88.66+/-6.58% in 20-29 year-old subjects to 76.80+/-9.32% in 70~79 year-old subjects. The correlation coefficient with age wae-0.4489.
Adult* ; Aging* ; Female ; Humans ; Lung Diseases ; Male ; Respiratory Function Tests

Diseases involving hip may influence on the anatomy of the proximal femur, especially on the endosteal canal shape. The simple radiographic comparative study was performed between normal and diseased hips. For the diseasd hip group, 74 hips ol' femoral head AVN(avascular necrosis) (average age: 49.3 years old, patients were all male) who had limped for average l9 months were selected and 77 male hips (average age: 48.9 years old) who had no prior hip disease were selected for the normal hip group. The external shape of both group showed no significant differences except for the femoral head dimensions. Statistically significant differences were ohserved hetween two groups in the proximal endosteal canal shape and cortical thickness. The femur of the diseased hip group had wider canal from the level of distal to lesser trochanter to the level of isthmus, with a significant reduction in the metaphyseal index (the ratio hetween the canal width proximal to lesser trochanter and distal to lesser trochanter) and the canal flare index (p<0.001). Theoretically this study suggests that the optimal fit and fill to the proximal endostcal canals of normal and diseased hips cannot be obtained by oneshape cementless femoral stcms.
Femur* ; Head ; Hip* ; Humans ; Male

Laser riidectomy with combined application of the Argon and the Nd-YAG laser was performed on 25 eyes of 24 patients with primary narrow angle glaucoma(19 eyes) or pupillary block glaucoma(6 eyes). Patients were followed for from a minimum of one month to maximum of six months and were evaluated the postoperative intraocular pressure, the iridectomy patency, the number of burst and the postoperative complication. In our study, the results obtained are as follows: 1. Pantency rates of iridectomy site were 100%. 2. Postoperative intraocular pressure were well controlled except one eye. 3. Numbers of burst were obviously decreased. 4. The bleeding during the iridectomy was noted in one eye(4%). 5. Immediate postoperative intraocular pressure elevation was seen in one eye(4%).
Argon* ; Hemorrhage ; Humans ; Intraocular Pressure ; Iridectomy* ; Lasers, Solid-State* ; Postoperative Complications