Multinodular goiter (MNG) is one of the benign thyroid neoplasm and nodular hyperplasia is the most common pathologic type. MNG could be misdiagnosed as a malignancy because of its characteristic, which is its growing tendency. A-70-year-old female was referred to our clinic from endocrinology, with the huge and recently rapid growing thyroid mass. We performed the neck sonography, its guided fine needle aspiration cytology (FNAC), neck CT and MRI. She was presumed as the malignant thyroid neoplasm except papillary carcinoma. The right completion thyroidectomy and anterior compartment neck dissection had been done and the nodular hyperplasia was diagnosed finally. We learned a valuable lesson from this case in the following. Even if the malignancy is strongly suggested in the radiology and clinically, more careful consideration in determining the surgical method and its extent is mandatory.
Biopsy, Fine-Needle ; Carcinoma, Papillary ; Endocrinology ; Female ; Goiter ; Humans ; Hyperplasia ; Neck ; Neck Dissection ; Thyroid Gland ; Thyroid Neoplasms ; Thyroidectomy

Multinodular goiter (MNG) is one of the benign thyroid neoplasm and nodular hyperplasia is the most common pathologic type. MNG could be misdiagnosed as a malignancy because of its characteristic, which is its growing tendency. A-70-year-old female was referred to our clinic from endocrinology, with the huge and recently rapid growing thyroid mass. We performed the neck sonography, its guided fine needle aspiration cytology (FNAC), neck CT and MRI. She was presumed as the malignant thyroid neoplasm except papillary carcinoma. The right completion thyroidectomy and anterior compartment neck dissection had been done and the nodular hyperplasia was diagnosed finally. We learned a valuable lesson from this case in the following. Even if the malignancy is strongly suggested in the radiology and clinically, more careful consideration in determining the surgical method and its extent is mandatory.
Biopsy, Fine-Needle ; Carcinoma, Papillary ; Endocrinology ; Female ; Goiter ; Humans ; Hyperplasia ; Neck ; Neck Dissection ; Thyroid Gland ; Thyroid Neoplasms ; Thyroidectomy

Neurofibroma is a benign neurogenic tumor thatmost often occurs in the head and neck region. However, a solitary neurofibroma on the nasolabial fold is extremely rare, with only a few reported cases reported in the English literature. A 45-year-old woman with a nasolabial mass visited our department, and we performed an excisional biopsy using asublabial approach. The histopathology of the mass revealed it to be neurofibroma. We report a unique case of neurofibromain thenasolabial region with an associated literature review. To the best of our knowledge, no such case has previouslybeen reported in Korea.
Biopsy ; Female ; Head ; Humans ; Korea ; Middle Aged ; Nasolabial Fold ; Neck ; Neurofibroma*

There are relatively rare cases concerning about concurrent papillary thyroid cancer and thyroid tuberculosis with cervical tuberculous lymphadenitis in English literature so far. Cervical lymphadenitis (scrofula) is a common manifestation of extra-pulmonary invasion of the tuberculosis. A cervical tuberculous lymphadenitis could be confused with metastatic lymph node from the thyroid cancer. A 49-year-old woman with multiple right thyroid nodules of Bethesda category VI referred our department for surgery. We performed the right thyroid lobectomy with anterior compartment neck dissection. The histopathology revealed concurrent papillary thyroid carcinoma and thyroid tuberculosis with cervical tuberculous lymphadenitis. We report a unique case of concurrent papillary thyroid cancer and tuberculosis involving the thyroid gland and ipsilateral paratracheal lymph node with literature review. To our best knowledge, such case has not been reported earlier.
Carcinoma ; Carcinoma, Papillary ; Female ; Humans ; Lymph Nodes* ; Lymphadenitis ; Middle Aged ; Neck Dissection ; Thyroid Gland* ; Thyroid Neoplasms* ; Thyroid Nodule ; Tuberculosis* ; Tuberculosis, Lymph Node

PURPOSE: We evaluated ocular penetration and drug level in tear after topical ofloxacin instillation in rabbit eye with amniotic membrane transplantation(AMT). METHODS: In the first set of experiment, 24 rabbits(24 eyes) were divided into 4 groups according to the epithelial removal or AMT. Topical ofloxacin was instilled 4 times every 15 minutes and then, 1 hour after the last eyedrop, the samples of amniotic membrane(AM), cornea and aqueous humor were collected. In the second set of experiment, 24 rabbits(24 eyes) were divided into 6 groups according to the freshness of AM or its attached time. Topical ofloxacin was applied to eyes and then, tear samples were collected at 30 minutes, 1, 2, 4, and 6 hours. Ofloxacin concentration in the samples of two experiments were evaluated using high performance liquid chromatography. RESULTS: Mean ofloxacin concentrations in cornea and aqueous humor were statistically higher in deepithelized corneas regardless of AMT(P<0.05). And mean tear levels of ofloxacin in AMT groups were statistically higher than those in non-AMT groups(P<0.05). CONCLUSIONS: AMT seems to interfere with the ocular penetration of topical ofloxacin in normal rabbit cornea, but rather enhances ofloxacin penetration in the cornea with epithelial defect. And also the ofloxacin level in tear was higher in eyes with AMT up to 1 hour after topical ofloxacin use. Therefore it seems that AM has potential to act as an effective drug delivery system.
Amnion* ; Aqueous Humor ; Chromatography, Liquid ; Cornea ; Drug Delivery Systems ; Ofloxacin*

In most cases, skull base osteomyelitis arises from infections of external auditory canal, middle ear or paranasal sinuses. On the other hand, atypical or central skull base osteomyelitis has no evidence of external otitis or other infection sources. It is often found located on clivus and involves lower cranial nerves and brainstem through the foramina of skull base. The overall rate of mortality reaches 10% and long-term neurologic sequelae are seen in additional 31% of cases regardless of aggressive treatment. We recently encountered a 68-year-old man with right facial pain and generalized headache, and we achieved good outcome with the recovery of vocal cord palsy and disappearance of headache by surgical debridement and long-term antibiotics. We report it with a review of literature.
Aged ; Anti-Bacterial Agents ; Brain Stem ; Cranial Fossa, Posterior ; Cranial Nerve Diseases* ; Cranial Nerves ; Debridement ; Ear Canal ; Ear, Middle ; Facial Pain ; Hand ; Headache ; Humans ; Mortality ; Osteomyelitis* ; Otitis Externa ; Paranasal Sinuses ; Skull Base* ; Vocal Cord Paralysis

While ancient schwannoma (AS) from the cervical sympathetic chain is very rare. Preoperative Horner's syndrome resulting from cervical sympathetic chain schwannoma (CSCS) is extremely rare. A 58-year-old woman visited our clinic with a huge lateral neck mass that had been present for thirteen years. Ptosis and enophthalmos were observed on the left eye. After radiologic evaluation, we assessed the CSCS by performing surgical excision. Finally, pathologic examination revealed it to be AS. There has been no recurrence for 15 months after discharge, however Horner's syndrome has become more prominent. We report this unique case of ancient schwannoma with literature review.
Enophthalmos ; Eye ; Female ; Horner Syndrome ; Humans ; Middle Aged ; Neck ; Neurilemmoma ; Preoperative Period ; Recurrence ; Sympathetic Nervous System

OBJECTIVE: This paper reports the possibility of using of a locking horizontal mattress suture technique in repairing lacerations that are difficult to suture with staples. METHODS: Data were collected retrospectively over a 6-month period regarding the routine repair of scalp lacerations: those in areas injured by a high energy blunt mechanism, continued to bleed after pressure, nonlinear or damaged skin repaired with a locking horizontal mattress technique, and simple interrupted technique. The effects of the two techniques used to repair scalp lacerations on wound healing, complication rate, and patient satisfaction were examined. The categorical variables are expressed as the number and percent. A Mann-Whitney-Wilcoxon test was used for statistical analysis. A P-value less than 0.05 was considered significant. RESULTS: Thirty-seven consecutive patients with scalp lacerations presented for care. Wound closure was accomplished with the locking horizontal mattress sutures in 40.5% (n=15) (median length, 5.0 cm; interquartile range [IQR], 4.0–7.0 cm). Simple interrupted sutures (median length, 4 cm; IQR, 3.0–5.0 cm) were used in 59.5% (n=22) (P=0.015). The frequency of additional bandage compression (P=0.008), frequency of exudative hemorrhage (P=0.018), and suture mark frequency at suture removal (P=0.047) were significantly lower in the locking horizontal mattress group. CONCLUSION: The locking horizontal mattress suture, which has the advantage of a horizontal mattress suture, may be one of the ways that can be used alternatively to treat scalp lacerations that difficult to suture with staples.
Bandages ; Hemorrhage ; Humans ; Lacerations* ; Methods* ; Patient Satisfaction ; Retrospective Studies ; Scalp* ; Skin ; Suture Techniques ; Sutures* ; Wound Healing ; Wounds and Injuries