1.Intralesional Recombinant Alpha-2a Interferon for the Treatment of Patients With Verruca.
Seung Won AHN ; Seong Joon SEO ; Chang Kwun HONG
Annals of Dermatology 2000;12(3):155-159
BACKGROUND: Interferon alpha-2a has already been shown to be effective in clinical use of virus-originated diseases such as hairy cell leukemia, condyloma acuminatum, and AIDS-related Kaposi's sarcoma. The use of recombinant alpha-interferon may allow common warts to be treated relatively atraumatically and with less incidence of recurrence. OBJECTIVE: We tried to determine the safety and effectiveness of intralesional injections of recombinant alpha-2a interferon in the treatment of patients with common warts. METHODS: A single wart on each patient was weekly injected with 0.75 to 1.5×10(5) IU/25mm2 of interferon for 8 weeks, and the response to treatment was followed up-to 6 months. RESULTS: Clearing of the treated wart at the end of treatment occurred in 5(71%) out of 7 patients and the rest showed no improvement. With evaluation for relapses up-to 6 months after treatment, warts relapsed in 2(40%) out of 5 patients. Therefore, 3(43%) out of 7 patients were completely free of warts 6 months after treatment. CONCLUSION: Intralesional recombinant interferon alpha-2a has a limited therapeutic effect, but may be considered as a therapeutic modality of recalcitrant verruca or when it can be anticipated that destructive techniques or blistering agents will not be tolerated.
Blister
;
Humans
;
Incidence
;
Injections, Intralesional
;
Interferon-alpha
;
Interferons*
;
Leukemia, Hairy Cell
;
Recurrence
;
Sarcoma, Kaposi
;
Warts*
2.Surgical Treatment of Intractable Epilepsy with Benign Brain Lesion.
Dae Hee SEO ; Seung Chyul HONG ; Seung Bong HONG ; Dae Won SEO
Journal of Korean Epilepsy Society 2005;9(1):3-9
Epilepsy surgery can be a safe, effective treatment for individuals with intractable partial epilepsy. There is increasing evidence that brain abnormalities in focal epilepsy are not restricted to a single area. The longstanding debate around the relationship between structural lesions and the epileptic zone remains unresolved. Patients with DNT (dysembryoplastic neuroepithelial tumor), which is an essentially benign tumor, can be cured by epilepsy surgery-oriented approach. Cortical dysplasia is frequently associated with DNT and seems to contribute to epileptogenic activity of DNT. Surgical treatment should be aimed at removal of the associated cortical dysplasia as well as DNT itself for ideal treatment of the disease. Simple lesionectomy of cavernous angioma would relieve seizures significantly, but not always. The concept of epilepsy surgery needs to be recruited in the treatment of cavernous angioma with seizures because diffusion of hemosiderin into the surrounding brain tissue and formation of cortical scars can make epileptogenic areas. Cortical dysplasia is a highly epileptogenic lesion constituting an important cause of medically intractable epilepsy and surgery is a treatment of choice in a selected group of patients. Identification and complete resection of the lesion and ictal onset zone are necessary to achieve a good surgical results. Intractable epilepsy accompanied by benign brain lesions can be treated surgically using the entire armamentarium of presurgical investigations. Deliberate resective procedures aimed at complete removal of dysplastic tissue and epiletogenically active areas on and around the lesion ensure excellent seizure control without permanent neurologic deficit.
Brain*
;
Cicatrix
;
Diffusion
;
Epilepsies, Partial
;
Epilepsy*
;
Hemangioma, Cavernous
;
Hemosiderin
;
Humans
;
Malformations of Cortical Development
;
Neurologic Manifestations
;
Seizures
3.Examination of Endoscopic Mucosal Resection of Early Gastric Cancer.
Seung Min LEE ; Seung Won SEO ; Jae Kyu SEONG ; Byung Seok LEE ; Hyun Yong JEONG
Korean Journal of Gastrointestinal Endoscopy 2002;24(3):129-134
BACKGROUND/AIMS: The endoscopic mucosal resection has now been adopted for a useful modality in both curative therapy and accurate diagnosis of early gastric cancer. A retrospective study was done to evaluate the indication and the limitation of endoscopic mucosal resection of early gastric cancer. METHODS: We studied 20 cases of early gastric cancer treated by endoscopic mucosal resection in Chungnam National University Hospital from November, 1995 to July, 1997. RESULTS: 1) The size affected the curability: 83. 3% of lesions less than 2 cm and 50. 0% of those larger than 2 cm were resected completely. 2) The depth of cancer invasion affected the curability: 87. 5% of lesion confined to mucosa were resected completely, while all of submucosal cancers were resected incompletely. 3) Among fourteen cases resected completely, three cases of lesions larger than 2 cm were residual cancer and two of those less than 2 cm were recurred locally. CONCLUSIONS: To be a curative therapy by endoscopic mucosal resection of early gastric cancer, we think that careful selection of the lesion, that is lesion less than 2cm and confined to mucosa, is necessary
Chungcheongnam-do
;
Diagnosis
;
Mucous Membrane
;
Neoplasm, Residual
;
Retrospective Studies
;
Stomach Neoplasms*
4.Ictal Hyperperfusion of Cerebellum and Basal Ganglia in Temporal Lobe Epilepsy: SPECT Subtraction.
Won Chul SHIN ; Seung Bong HONG ; Woo Suk TAE ; Dae Won SEO ; Sang Eun KIM
Korean Journal of Nuclear Medicine 2001;35(1):12-22
PURPOSE: The ictal perfusion patterns of cerebellum and basal ganglia have not been systematically investigated in patients with temporal lobe epilepsy (TLE). Their ictal perfusion patterns were analyzed in relation with temporal lobe and frontal lobe hyperperfusion during TLE seizures using SPECT subtraction. MATERIALS AND METHODS: Thirty-three TLE patients had interictal and ictal SPECT, video-EEG monitoring, SPGR MRI, and SPECT subtraction with MRI co-registration. RESULTS: The vermian cerebellar hyperperfusion (CH) was observed in 26 patients (78.8%) and hemispheric CH in 25 (75.8%). Compared to the side of epileptogenic temporal lobe, there were seven ipsilateral hemispheric CH (28.0%), fifteen contralateral hemispheric CH (60.0%) and three bilateral hemispheric CH (12.0%). CH was more frequently observed in patients with additional frontal hyperperfusion (14/15, 93.3%) than in patients without frontal hyperperfusion (11/18, 61.1%). The basal ganglia hyperperfusion (BGH) was seen in 11 of the 15 patients with frontotemporal hyperperfusion (73.3%) and 11 of the 18 with temporal hyperperfusion only (61.1%). In 17 patients with unilateral BGH, contralateral CH to the BGH was observed in 14 (82.5%) and ipsilateral CH to BGH in 2 (11.8%) and bilateral CH in 1 (5.9%). CONCLUSION: The cerebellar hyperperfusion and basal ganglia hyperperfusion during seizures of TLE can be contralateral, ipsilateral or bilateral to the seizure focus. The presence of additional frontal or basal ganglia hyperperfusion was more frequently associated with contralateral hemispheric CH to their sides. However, temporal lobe hyperperfusion appears to be related with both ipsilateral and contralateral hemispheric CH.
Basal Ganglia*
;
Cerebellum*
;
Epilepsy, Temporal Lobe*
;
Frontal Lobe
;
Humans
;
Magnetic Resonance Imaging
;
Perfusion
;
Seizures
;
Temporal Lobe*
;
Tomography, Emission-Computed, Single-Photon
5.Experimental study to the effect of hyperbaric oxygen on the survival of the composite graft.
Hyeung Gyo SEO ; Seung Ha PARK ; Chun Eun CHUNG ; Won Kyung KANG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1991;18(5):779-787
No abstract available.
Oxygen*
;
Transplants*
6.Keratoacanthoma in Co-existence with Nevus Sebaceus.
Seung Won AHN ; Tae Jong CHUN ; Seong Joon SEO ; Chang Kwun HONG
Annals of Dermatology 2000;12(2):138-140
Nevus sebaceus of Jadassohn has been referred to as a organoid nevus that classically evolves through three stages and may be associated with a range of skin tumors, and of these, syringocystadenoma papilliferum and basal cell carcinoma have been commonly reported to occur. The occurrence of keratoacanthoma is a very rare event in nevus sebaceus. Herein we report on a 23-year-old man with nevus sebaceus of the cheek. He represents a keratoacanthoma arising within nevus sebaceus.
Carcinoma, Basal Cell
;
Cheek
;
Humans
;
Keratoacanthoma*
;
Nevus*
;
Nevus, Sebaceous of Jadassohn
;
Organoids
;
Skin
;
Young Adult
7.Prenatal diagnosis of familial congenital heart disease by fetal echocardiography.
Seung Hun LEE ; Yong Won PARK ; Kyung SEO ; Se Kwang KIM ; Chan Ho SONG
Korean Journal of Obstetrics and Gynecology 1991;34(7):1008-1014
No abstract available.
Echocardiography*
;
Heart Defects, Congenital*
;
Prenatal Diagnosis*
8.Echocardiographic Preoperative Prediction of Prosthetic Aortic Valve Size in Patient with Aortic Valve Replacment.
Seung Won HAM ; Young Soon KIM ; Se Woong SEO ; Sung Gu KIM ; Young Joo KWON
Korean Circulation Journal 1987;17(3):411-417
Aortic root diameter by two dimensional and M-mode echocardiography in predicting prosthetic aortic valve size preoperatively was measured in 10 adult patients undergoing aortic valve replacement. Correlation of aortic root diameter measured by two dimensional echocardiography and actual prosthetic valve size implanted by aortic valve replacement was excellent. Correlation coefficient was statistically significant (r=0.91, P<0.001). Correlation of aortic root diameter measured by M-mode echocardiography and actual prosthetic valve size was also excellent. Correlation coefficient was statistically significant (r=0.86, P<0.001). This study demonstrates that aortic root diameter by two dimensional and M-mode echocardiography can accurately predict prosthetic aortic valve size in patient undergoing aortic valve replacement.
Adult
;
Aortic Valve*
;
Echocardiography*
;
Humans
9.Eosinophilia-Myalgia Syndrome not Associated with the Ingestion of Nutritional Supplements.
Seung Won AHN ; Bong Ju SHIN ; Seong Jun SEO ; Chang Kwun HONG
Annals of Dermatology 2002;14(1):48-50
Eosinophilia-myalgia syndrome(EMS) is a systemic illness that occurred as an epidemic by ingestion of over-the counter L-tryptophan preparation in the United States in October 1989. We report a Korean case of EMS not associated with the ingestion of either L-tryptophan or other nutritional supplements such as lysine and niacin.
Eating*
;
Eosinophilia-Myalgia Syndrome*
;
Lysine
;
Niacin
;
Tryptophan
;
United States
10.A Case of Unilateral Idiopathic Atrophoderma of Pasini and Pierini.
Bong Ju SHIN ; Seung Won AHN ; Seong Jun SEO ; Chang Kwun HONG
Annals of Dermatology 2002;14(1):35-37
Idiopathic atrophoderma of Pasini and Pierini(IAPP) is an uncommon condition of unknown etiology and typically affects persons in the second and third decades of life. IAPP consists of asymptomatic grey to brown depressed lesions with "cliff drop" borders, which are usually bilateral and located on the trunk. A 40-year-old woman visited our department because of unilateral atrophic lesions on the abdomen, right arm, and posterior aspect of right thigh for 20 years. Laboratory evaluations were normal and histologic examination revealed significantly decreased thickness in dermis. We report an unusual case of idiopathic atrophoderma of Pasini and Pierini presenting unilateral distribution.
Abdomen
;
Adult
;
Arm
;
Dermis
;
Female
;
Humans
;
Thigh