BACKGROUND: Stress has long been known to play a role in many dermatologic disorders and can affect the onset and course of the disorder in some patients. Stress-induced exacerbation or onset of symptoms has been reported in chronic urticaria, alopecia areata, herpes simplex, herpes zoster, and psoriasis vulgaris, and these diseases can be classified as stress-associated dermatoses. Beta beta-endorphin is one of the most important mediators of stress, which is known to be generated upon stimulation of the pituitary-adrenal axis, and its secretion increases during periods of stress. OBJECTIVE: In order to see wheather beta-endorphin might be related to the onset or recurrence of stress-associated dermatoses, we compared the plasma concentration of beta-endorphin in patients with stress-associated dermatoses with those of healthy subjects. METHODS: The concentration of beta-endorphin. In sera was quantified by radioimmunoassay, using the INCSTAB 125I RIA Kit for plasma beta-endorphin, Each patient was asked to indicate if they believed that their skin problem began after an important stressful event in their lives. RESULTS: There was no significant difference in plasma beta-endorphin levels between patients with chronic urticaria, alopecia areata, herpes simplex, and herpes zoster and healthy subjects(p>0.05), whereas in patients with psoriasis vulgaris, plasma level of beta-endorphin was significantly increased (p<0.001). There was no relationship between the stressful events and plasma beta-endorphin concentrations. CONCLUSIONS: The plasma beta-endorphin level is not correlated with the onset or recurrence of stress-associated dermatoses such as chronic urticaria, alopecia areata, herpes simplex, and herpes zoster. The increase in beta-endorphin in psoriasis vulgaris is more likely that this peptide is generated by the lymphocyte infiltrated in the skin and/or by lymphocytes when they recirculate rather than by the activation of the pituitary-adrenal axis by stress.
Alopecia Areata ; Axis, Cervical Vertebra ; beta-Endorphin ; Endorphins* ; Herpes Simplex ; Herpes Zoster ; Humans ; Life Change Events ; Lymphocytes ; Plasma* ; Psoriasis ; Radioimmunoassay ; Recurrence ; Skin ; Skin Diseases* ; Urticaria

We report herein a 53-year-old male patient with a large condyloma acuminaturn of 16 months duration on his penis. Clinically, an approximat;ely 3.5 X 2.0 Cm sized, asyrnptomatic, verrucous-surfaced, papilloma was present on his prepuce and glans. Elistological examination disclosed hyperkeratosis, marked acanthosis, papillomatosis, vacuolated upper malphigian cells, dilated capillaries, and mononuclear infiltrntes in the upper dermis. Trial of DNCB immunotherapy showed a dramatic effect on tumor regression.
Capillaries ; Dermis ; Dinitrochlorobenzene* ; Humans ; Immunotherapy ; Male ; Middle Aged ; Papilloma ; Penis

Various epidermal changes overlying a dermatofibroma can be induced through the proliferation of pluripotential epidermal cells by the stimulation of mesenchymal factors. The authors report a case of dermatofibroma in a 55-year-old male who had a reddish brown, asymptomatic nodule of 5 years duration on his left forearm. The biopsy specimen revealed a dermatofibroma of cellular type associated with epidermal changes: (1) acanthosis; (2) elongation of rete ridges; (3) thin interlacing epidermal strands with increased pigmentation resembling seborrheic keratosis or fibroepithelioma; (4) immature hair follicles and sebaceous lobules; (5) hair germ like buddings; (6) superficial basal cell epithelioma-like proliferations.
Biopsy ; Forearm ; Hair ; Hair Follicle ; Histiocytoma, Benign Fibrous* ; Humans ; Keratosis, Seborrheic ; Male ; Middle Aged ; Pigmentation

We report herein a case of tuberculosis cutis orificialis in a 50-year-old man. He suffered from well demarcated, 2x5cm sized, slightly tender, pus discharging, perianal ulcer with bluish edges for 3 months. The biopsy specimen from the ulcer revealed tuberculoid structure with Langhans giant cells in the deep dermis and a few acid-fast bacilli. AFB cultures from the sputum, pus, and tissue were successful. Intradermal test with PPD showed positive result. Chest roentgenographic findings disclosed advanced pulmonary tuberculosis. Almost complete healing of the perianal ulcers occurred following 2 months of therapy using antituberculosis drugs.
Biopsy ; Dermis ; Giant Cells, Langhans ; Humans ; Intradermal Tests ; Middle Aged ; Sputum ; Suppuration ; Thorax ; Tuberculosis* ; Tuberculosis, Pulmonary ; Ulcer

Spontaneous testicular hemorrhagic necrosis is a rare disease usually associated with testicular torsion. Partially involved and suspicious testis tumor cases are also defined from orchiectomy specimens. Herein, a spontaneous hemorrhagic necrosis, without any testicular torsion, but with involvement of the whole testicle and epididymis, is reported. A 21 year old patient, who presented with a painless left testicular enlargement of several days duration was believed, based on physical examination, ultrasonography and elevation of serum LDH, to have a testicular tumor. Diagnosis was made only after radical orchiectomy and histopathological examination.
Diagnosis ; Epididymis ; Hemorrhage ; Humans ; Male ; Necrosis* ; Orchiectomy ; Physical Examination ; Rare Diseases ; Spermatic Cord Torsion ; Testis* ; Ultrasonography ; Young Adult

No abstract available.
Histiocytoma*

The goals of this study were to present presurgical naso-alveolar molding (PNAM) appliance in unilateral cleft lip and palate treatment and to evaluate the effects of PNAM appliance on alveolar molding. Samples were consisted of 4 unilateral cleft lip and palate infants (3 males and 1 female, mean age=23.2 days after birth) who were treated with PNAM appliances in Department of Orthodontics, Seoul National University Dental Hospital. Average alveolar cleft gap between the greater and lesser segment was 8.27 mm and average duration of alveolar molding treatment was 9.7 weeks. These patients' models were obtained at initial visit (TI) and after successful alveolar molding (T2). Seven linear and five angular variables were measured by using photometry and digital caliper. All statistical analyses were performed by SPSS win ver. 7.5 program. Paired t-test was used to compare the mean values. 1. The posterior part of alveolar segments are the stable structures during alveolar molding treatment period in infants. 2. Forward growth of the greater segment may be hindered by the action of alveolar molding. 3. The closure of cleft gap during alveolar molding were usually due to inward and backward bending of the anterior part of the greater segment and outward bending of the whole lesser segment.
Cleft Lip* ; Female ; Fungi* ; Humans ; Infant ; Male ; Orthodontics ; Palate* ; Photometry ; Seoul

Cleft lip and/or palate is one of the most common congenital craniofacial anomalies. According to previous epidemiologic studies, incidence of cleft lip and/or palate has been increasing nowadays. However, there is no report about epidemiologic study of cleft lip and/or palate patients who visited dept. of orthodontics in Korea. So the purpose of this study was to provide the epidemiological characteristics and important basic clinical data for the diagnosis and the treatment of the cleft lip and/or palate patients. With the orthodontic and the charts, diagnostic models and X-ray films from 250 patients with cleft lip and/or palate who visited Dept. of Orthodontics, Seoul National University Dental Hospital during the last 11 years, the authors investigated patient`s visiting year, types of cleft, patient`s gender, and Angle`s classification of malocclusion, and surgery timing. 1. The number of cleft patients who visited Dept. of Orthodontics, SNUDH increased during 1988-1990and then it declined until 1992. From 1993 to 1996, it showed a stationary trend. After 1997 it showed an overwhelmingly increasing trend. 2. In the cleft type, the ratio of cleft lip : cleft lip and alveolus : cleft palate : cleft lip and palate was 7.6 : 19.2 : 9.6 : 63.6. In cleft position, unilateral clefts were more than bilateral ones (cleft lip 79 : 21, cleft lip and alveolus 77 : 23, cleft lip and palate 75.5:24.5). In cleft side, left clefts were more than right cleft (cleft lip 53.3 : 46.7, cleft lip and alveolus 59.5 : 40.5, cleft lip and palate 59.2 : 40.8). 3. In gender ratio, males were more than females in cleft lip (57.9 : 42.1), cleft lip and alveolus (68.8 : 31.2) and cleft lip and palate (76.1 : 23.9). But in cleft palate females were more than males as 41.7 : 58.3. 4. In the age groups, 7-12 year group was the most abundant as 52%, and then 0-6 year group (20.4%), 13-18 year group (17.2%), more than 18 year group (10.4%) were followed as descending order. 5. Most of the cleft lip repair surgeries were operated in 0-3 month (60.3%) and 4-6 month (17.9%). 6. The cleft palate repair surgeries were done in 1-2 year (31.7%), 0-1 year (25.6%), 2-3 year (12.1%), more than 5 year (11.6%) as descending order. 7. The lip scar revision surgeries were done before admission at elementary school 60%. (4-6 year (27.5%), 6-8 year (19.6%), more than 10 year (19.6%), 2-4 year (13.7%) as descending order) 8. The rhinoplasties were done before admission at elementary school in 51.7%. (0-2 year (7.1%), 2-4 year (14.3%), 4-6 year (21.4%), 6-8 year (14.3%)) 9. The pharyngeal flap were done at 6 Y (72.5 months) after birth on average and there was even distribution of surgery timing. 10. In relationship between Angle`s classification of malocclusion and cleft types, Class I was most abundant and Class III, Class II were followed as descending order in cleft lip group. But Class III was most abundant and Class I, Class II were followed as descending order in cleft lip and alveolus group, cleft plate group, and cleft lip and palate group. The percentage of frequency in Class III malocclusion was overwhelmingly higher in cleft lip and palate group than any other groups. 11. Because the frequency of Class III malocclusion was most prevalent in all age groups, anterior crossbite was the most common chief complaint of cleft patients.
Cicatrix ; Classification ; Cleft Lip* ; Cleft Palate ; Diagnosis ; Epidemiologic Studies ; Female ; Humans ; Incidence ; Korea ; Lip ; Male ; Malocclusion ; Orthodontics* ; Palate* ; Parturition ; Rhinoplasty ; Seoul* ; X-Ray Film

Cleft lip and/or palate (CLP) is one of the most common congenital craniofacial anomalies and occurs more frequently in Asian people. Dental abnormalities in number, size, shape, and eruption of teeth are frequently associated with CLP. The purposes of this study were to investigate the effects of CLP on number, size, shape and eruption of teeth and to provide basic clinical data for diagnosis and treatment of the CLP patients. With the orthodontic and cleft charts, diagnostic models, orthopantomograms and intraoral x-ray films from 241 CLP patients who visited Dept. of Orthodontics, Seoul National University Dental Hospital, we evaluated the frequency of congenital missing teeth, supernumerary teeth, impacted teeth, and microdontia. The results were as follows ; 1. Frequency of congenital missing was relatively high up to 56.8 %. Congenital missing occurred frequently in the maxillary lateral incisor and the maxillary second premolar. Among the CLP types, frequencies of congenital missing in cleft lip and palate group and cleft lip and alveolus group were higher than those of cleft lip group and cleft palate group. And bilateral cleft showed higher frequencies than unilateral ones. 2. Supernumerary tooth was shown in 11.2 % of CLP patients. It occurred frequently in the area between the maxillary lateral incisors and the maxillary canine. Among the CLP types, cleft lip group showed relatively most highest frequency. 3. Impaction was shown in 18.3 % of CLP patients. It occurred most frequently in the maxillary lateral incisor and the maxillary canine than other teeth. Among the CLP types, cleft lip group and cleft lip and palate group showed most highest frequencies. 4. Microdontia was shown in 15.8 % of CLP patients. It occurred the most frequently in the maxillary lateral incisors and maxillary canines. Among the CLP types, cleft lip and alveolus group and cleft lip and palate group showed relatively higher frequencies. There was no microdontia in cleft palate group.
Asian Continental Ancestry Group ; Bicuspid ; Cleft Lip* ; Cleft Palate ; Diagnosis ; Humans ; Incisor ; Orthodontics ; Palate* ; Seoul ; Tooth* ; Tooth, Impacted ; Tooth, Supernumerary ; X-Ray Film

Adult wound healing is accompanied with inflammation and eventual scar formation, whereas fetal wounds heal rapidly by mesenchymal proliferation without significant inflammatory cell participation and with minimal or no scar formation. The cellular mechanisms underlying these differing forms of wound healing are unknown but the extracellular matrix, through its effects on cell function, may play a key role. Therefore the purpose of this study is to investigate the spatial and temporal deposition of several component of extracellular matrix, which are known to be involved with scar formation, in the artificially created cleft lip wound healing of fetuses. The author had undergone hysterotomy and created cleft lip-like defects on fetuses of New Zealand White Rabbit in mid-third trimester(24 days). Fetuses were divided into the repaired group, the unrepaired group and the sham-operated control group. At 1, 2, 3, 5, 7 days after procedure, fetuses were obtained by Caeserean section. After documenting the viability of fetuses, they were photographed to compare size and facial morphology and sectioned for histological examination by H & E stain and spatial and temporal deposition of collagen type I. III, IV, V and fibionectin, laminin by immunohistochemical method. The findings are summarized as follows: 1. There were lack of inflammation in the repaired and the unrepaired group during experimental periods. 2. The reepithelialization of the unrepaired group was slower than that of the repaired group. 3. Collagen I, III, V were found from post-op. third day. There were no difference of distribution in the control, the repaired and the unrepaired group. Collagen types I, III, V were present in all groups with restoration of the normal collagen pattern in the fetus. This implies that lack of scarring in fetal wounds is due to the difference of collagen organization pattern within wound and not simply lack of collagen formation. 4. Collagen IV was slightly increased at post-op. third day and decreased after post-op, fifth day. Eventually there were no differences in the control, the repaired and the unrepaired group. Laminin was found at post-op. fifth day and maintained staining density until post-op. seventh day. There were no differences in the control, the repaired and the unrepaired group. According to staining of laminin and collagen type IV in epithelial basement membrane, formation of epithelial basement membrane was not completed until reepithelialization was finished. 5. According to staining of laminin and collagen type IV, there were no increase of neovascularity in the repaired and the unrepaired group. 6. Fbbronectin was increased until post-op. third day at fibrin clot, wound base and margin and decreased after post-op. fifth day. Eventually, there were no differences in the control, the repaired and the unrepaired group, So it implies fibronectin plays a role as provisional matrix for fetal wound healing
Adult ; Basement Membrane ; Cicatrix ; Cleft Lip* ; Collagen ; Collagen Type I ; Collagen Type IV ; Extracellular Matrix* ; Fetus* ; Fibrin ; Fibronectins ; Humans ; Hysterotomy ; Immunohistochemistry ; Inflammation ; Laminin ; New Zealand ; Wound Healing* ; Wounds and Injuries*