1.Minimal sedation using oral sedatives for multi-visit dental treatment in an adult patient with dental phobia
Journal of Dental Anesthesia and Pain Medicine 2021;21(4):369-376
In adult patients with dental phobia, dental treatment may be difficult, or may not be possible. Depending on the level of fear or anxiety, non-pharmacological or pharmacological behavior management techniques are used in the dental treatment of such patients. Among the pharmacological behavior management techniques, minimal sedation, that is, the lowest depth of sedation, can be easily obtained in adult patients using oral sedatives, does not require special equipment or tools, and does not affect ventilatory and cardiovascular function. Diazepam is an anxiolytic drug belonging to the benzodiazepine family that, in addition to relieving anxiety, produces muscle relaxation, and is a representative drug used in adult patients with fear of dental treatment. Herein, we report the case of a 50-year-old woman with severe dental fear who successfully underwent long-term dental treatment in approximately 20 visits with minimal sedation using oral diazepam. In addition, we reviewed the considerations for the use of benzodiazepines for minimal sedation.
2.Minimal sedation using oral sedatives for multi-visit dental treatment in an adult patient with dental phobia
Journal of Dental Anesthesia and Pain Medicine 2021;21(4):369-376
In adult patients with dental phobia, dental treatment may be difficult, or may not be possible. Depending on the level of fear or anxiety, non-pharmacological or pharmacological behavior management techniques are used in the dental treatment of such patients. Among the pharmacological behavior management techniques, minimal sedation, that is, the lowest depth of sedation, can be easily obtained in adult patients using oral sedatives, does not require special equipment or tools, and does not affect ventilatory and cardiovascular function. Diazepam is an anxiolytic drug belonging to the benzodiazepine family that, in addition to relieving anxiety, produces muscle relaxation, and is a representative drug used in adult patients with fear of dental treatment. Herein, we report the case of a 50-year-old woman with severe dental fear who successfully underwent long-term dental treatment in approximately 20 visits with minimal sedation using oral diazepam. In addition, we reviewed the considerations for the use of benzodiazepines for minimal sedation.
3.Effects of Several Biodegradable Controlled-Release Local Delivery Drugs on the Treatment of Periodontitis.
Dae Seung YANG ; Kyung Tae YOU ; Sung Hee PI ; Myung Yeon LEE ; Yong Ouk YOU ; Hyung Keun YOU ; Hyung Shik SHIN
The Journal of the Korean Academy of Periodontology 1999;29(4):725-735
The present study was performed to evaluate the clinical effects following local application of 30% minocycline strip(polycaprolactone), 2% minocycline gel(hydro-carbon gel) and 12% minocycline strip(polylactide, Minodent) to augment scaling and root planing in patients with chronic adult periodontitis. Forty teeth with periodontitis were enrolled in the study anddistributed into 4 groups including control group. All patients performed standardized oral hygiene instructions and mechanical debridement at the beginning of the study and then each local delivery drugs were inserted into periodontal pocket in each groups. Examinations regarding plaque index(PI), papillary bleeding index (PBI), probing pocket depth (PPD) were carried out at 0, 2, 4 weeks. All experimental groups showed statistically significant differences between baseline and 2 and 4 weeks in every clinical indices. Especially, 30%minocycline strip and Minodent group showed a significant improvement in PBI at 2 weeks and in PPD at 2 and 4 weeks. In conclusion, highly bio-resorbable Minodent delivered subgingivally as an adjunct to scaling and root planing induces better clinical effects for periodontal health than 2% minocycline gel and control group.
Adult
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Male
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Female
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Humans
4.Co-culture of mouse 2 - cell embryos.
Hye Kyung PARK ; Gil Woo LEE ; Seung Hwan YOU ; Sang Hun CHA ; Im Soon LEE ; Tae Ho CHO
Korean Journal of Obstetrics and Gynecology 1993;36(7):1491-1495
No abstract available.
Animals
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Coculture Techniques*
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Embryonic Structures*
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Mice*
5.The Role of Surgical Excision in the Management of Non-suppurative BCG Lymphadenitis.
Seung Tae YOU ; Dae Seung KWEN ; Jun Sik KIM ; Duk Jin MOON
Journal of the Korean Surgical Society 2004;67(5):407-411
PURPOSE: Regional lymphadenitis is the most common complication of BCG vaccination and has various clinical course and prognosis, but there are no accurate guidelines for the management BCG lymphadenitis. This study was performed to reveal the clinical course of BCG lymphadenitis and provide guidelines for its management by comparison of observation and medication groups. METHODS: Between January, 2002 and April, 2003, 45 patients with non-suppurative lymphadenitis were reviewed. They were divided into two groups, and retrospectively compared. Group I consisted of 25 observation cases and group II of 20 antituberculous medication cases. RESULTS: The most prevalent age group of the 45 cases was three months old, and the most prevalent site of lesion was the ipsilateral axilla. A palpable single lesion was the most common finding. According to treatment (observation vs. antituberculous medication), the medication did not affect the prevention of suppuration. CONCLUSION: For the management of BCG lymphadenitis, systemic antituberculous medication and observation are not recommended, with active surgical resection being the treatment of choice.
Axilla
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Humans
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Lymphadenitis*
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Mycobacterium bovis*
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Prognosis
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Retrospective Studies
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Suppuration
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Vaccination
6.Systemic macrophage depletion attenuates infarct size in an experimental mouse model of stroke
Seung-Won LEE ; Dong-Jun SONG ; Han-Seung RYU ; You-Sub KIM ; Tae-Sun KIM ; Sung-Pil JOO
Journal of Cerebrovascular and Endovascular Neurosurgery 2021;23(4):304-313
Objective:
Macrophages have been shown to play important roles in various pathophysiological processes of the central nervous system via neuroinflammation, leading to an increased interest in macrophage biology. Circulating blood monocytes are among the first cells to infiltrate the brain after ischemic stroke; however, the role of innate immune cells such as monocytes and macrophages remains to be elucidated. Here, we investigated the association between blood monocytes and infarct size following ischemic stroke.
Methods:
We induced stroke using a focal ischemia mouse model through middle cerebral artery suture occlusion. To deplete circulating blood monocytes, clodronate was injected intraperitoneally 24 h before the surgery. Animals were sacrificed at specified time points, and the infarct size and mRNA expression were then measured.
Results:
The clodronate-injected mice showed significantly smaller infarct size than the control mice. Immunohistochemical staining revealed that monocyte depletion significantly blocked the infiltration of macrophages and microglia. The mRNA expression levels of macrophage and microglia markers were higher in the left infarcted brain than in the right non-infarcted brain.
Conclusions
In summary, monocyte depletion reduced the infarct size and mitigated neurological deficits in mice following ischemic stroke, likely by blocking the infiltration of inflammatory cells such as macrophages and microglia.
7.Renal Cell Carcinoma in a Right Malrotated Kidney.
Tae Joon LIM ; Seung Kwon CHOI ; Hyun Wook YOU ; Myung Joon KIM ; Jae Sung AHN ; Tae Gu KIM ; Jin Ill KIM ; Seung Hyun JEON
Korean Journal of Urology 2011;52(11):792-794
The authors report a case of renal cell carcinoma in a right malrotated (horizontal axis) kidney. The patient was treated by hand-assisted laparoscopic radical nephrectomy. This is the first report of a horizontal axis malrotated kidney with renal cell carcinoma.
Axis, Cervical Vertebra
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Carcinoma, Renal Cell
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Humans
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Kidney
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Nephrectomy
8.Salivary Duct Carcinoma of the Deep Lobe of the Parotid Gland: A Rare Clinical Finding.
Hi Jin YOU ; Tae Kyoung YUN ; Seong Ho JEONG ; Eun Sang DHONG ; Seung Kyu HAN
Archives of Plastic Surgery 2016;43(1):107-110
No abstract available.
Parotid Gland*
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Salivary Ducts*
9.Familial Noonan Syndrome Confirmed by PTPN11 Gene Test.
You Suk KIM ; Seung Tae LEE ; Chang Seok KI ; Mi Jung PARK
Journal of Korean Society of Pediatric Endocrinology 2008;13(1):117-121
Noonan syndrome is characterized by short stature, mental retardation, typical facial morphology, webbed neck and congenital heart disease. Noonan syndrome can be inherited in an autosomal dominant manner but all Korean patients with Noonan syndrome have been reported as sporadic cases thus far. In approximately 50-60% of cases, the disease is caused by mutation in the PTPN11 (protein tyrosine phosphatase, nonreceptor type 11) gene on chromosome 12, encoding SHP-2 (Src homology protein-tyrosine phosphatase-2). We have experienced a boy and his father with typical clinical features of Noonan syndrome in whom Asn58Asp mutation of the PTPN11 gene were identified. To the best of our knowledge, this is the first report of genetically confirmed familial Noonan syndrome in Korea.
Chromosomes, Human, Pair 12
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Fathers
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Heart Diseases
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Humans
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Intellectual Disability
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Neck
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Noonan Syndrome
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Tyrosine
10.Traumatic Dural Venous Sinus Injury.
You Sub KIM ; Seung Hoon JUNG ; Dong Ho LIM ; Tae Sun KIM ; Jae Hyoo KIM ; Jung Kil LEE
Korean Journal of Neurotrauma 2015;11(2):118-123
OBJECTIVE: The importance of traumatic dural venous sinus injury lies in the probability of massive blood loss at the time of trauma or emergency operation resulting in a high mortality rate during the perioperative period. We considered the appropriate methods of treatment that are most essential in the overall management of traumatic dural venous sinus injuries. METHODS: We conducted a retrospective review of all cases involving patients with dural venous sinus injury who presented to our hospital between January 1999 and December 2014. RESULTS: Between January 1999 and December 2014, 20 patients with a dural venous sinus injury out of the 1,200 patients with severe head injuries who had been operated upon in our clinic were reviewed retrospectively. There were 17 male and 3 female patients. In 11 out of the 13 patients with a linear skull fracture crossing the dural venous sinus, massive blood loss from the injured sinus wall could be controlled by simple digital pressure using Gelfoam. All 5 patients with a linear skull fracture parallel to the sinus over the venous sinus developed massive sinus bleeding that could not be controlled by simple digital pressure. CONCLUSION: When there is a linear skull fracture parallel to the sinus over the dural venous sinus or a depressed skull fracture penetrating the sinus, the surgeon should be prepared for the possibility of potentially fatal venous sinus injury, even in the absence of a hematoma.
Craniocerebral Trauma
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Emergencies
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Female
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Gelatin Sponge, Absorbable
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Hematoma
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Hemorrhage
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Humans
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Male
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Mortality
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Perioperative Period
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Retrospective Studies
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Skull Fracture, Depressed
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Skull Fractures
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Superior Sagittal Sinus