No abstract available.
Transplantation*

25 Patients were received major spinal surgeries at main operating theater of Kangnam General Hospital from May 1990 to December 1990 by using the Haemonetics cell saver which was employed as an intraoperative blood salvage and autologous blood transfuser. The products of washed red blood cells were an average of 1490 cc packed RBC per case. Under the Light Microscopy, Washed RBC disclosed the morphologies of normal RBC size and shape. Fragmented RBCs or cell debris were not found and in one case agglutinated and denaturated RBCs were seen. While 20 patients were received spinal surgery prior to the utilization of cell saver, an average of 7.85 units of banked whole blood was transfused compared with 5.55 units in the cases of using the cell saver (p<0.05). Homologous banked blood utilization during spinal surgery declined more than 30% with the use of the cell saver. There was no evidence of infection, renal and/or hepatic failure related to the use of the cell saver. Haemonetics cell saver appeared to be safe, efficient and more over in some instanes life saving.
Erythrocytes ; Hospitals, General ; Humans ; Liver Failure ; Microscopy ; Operative Blood Salvage*

BACKGROUND: Radiofrequency (RF) interstitial hyperthermia has recently been shown to be a beneficial treatment modality for human malignant gliomas. It has also been shown that the thermal threshold dose for histopathological damage in the rat brain was heating at 41 degreesCfor 30 min. In the present study, we investigated apoptosis and necrosis of the neuronal cells in the brains of Fischer rats at different times after interstitial heating with lower than the thermal threshold dose. We also measured the isopeptide bond formation in neuronal cells showing apoptosis or necrosis. METHODS: The applicator needles of the RF interstitial heating device, connected to the Thermotron IV was applied to heat the brain at 39, 40, and 41 degreesCfor 30 minutes. Sham-heated control rats were treated the same as the heated rats. The sham-heated animals and those heated at 40 degreesCfor 30 min were sacrificed at 4, 72, 120, and 168 hours after heating, respectively, and the animals heated at 39 and 41 degreesCfor 30 minutes were sacrificed at 168 hours after heating. Coronally sectioned brain tissue, encompassing the heated lesions, were studied immunohistochemically for the expression of TGase1, TGase2, and TGase3, isopeptide. TUNEL assay was performed to examine apoptosis. RESULTS: Immunohistochemical studies showed that in the brains heated at 40 degreesCfor 30 minutes, necrosis with the maximal nuclear isopeptide-positive neuronal cells of the cerebral cortex were seen at 4 hours; The maximal number of isopep-tide- positive neuronal cells showing apoptosis was at 168 hours. CONCLUSIONS: Necrosis of neuronal cells following mild interstitial hyperthermia was maximal at 4 hours and apoptosis was maximal at 168 hours. Neuronal cells showing necrosis or apoptosis formed isopeptide bonds in their nuclei.
Animals ; Apoptosis ; Brain* ; Cell Death* ; Cerebral Cortex ; Fever* ; Glioma ; Heating ; Hot Temperature ; Humans ; In Situ Nick-End Labeling ; Necrosis ; Needles ; Neurons* ; Rats* ; Rats, Inbred F344

No abstract available.

No abstract available.

No abstract available.
Mitral Valve*

Angiosarcoma is a rare malignant vascular tumor featuring endothelial cells. Angiosarcoma have four clinical manifestations that are angiosarcoma in the scalp and face, angiosarcoma in chronic lymphedematous areas, angiosarcoma in previously irradiated sites and malignant angioendothelioma. The most common lesions are those that occur in the scalp and in the face of elderly people. The male to female ratio is 2 : 1. In my case, a 65-years-old male presented progressively growing tumor on the left frontal scalp. The tumor began as an ill-defined bluish macule, which was initially mistaken for an old bruise. The rapidly growing lesion extended to form violaceousm compressible and hemorrhagic plaques. The mass was 6 x 4.5 cm in size. Distinguishing features are the frequent occurrence of a peripheral erythematous ring, satellite nodules, the presence of intratumoral hemorrhage, and the tendency to bleed spontaneously, or after minimal trauma. Histologically the tumor comprised anaplastic pleomorphic endothelial cells with new vascular channels and irregular vascular spaces lined by plump endothelial cell's stroma among them. The lesion was diagnosed as angiosarcoma. No metastasis to other organs were found as evaluated by chest CT, bone and liver scan. We performed wide excision, skin graft, bilateral transposition flap, chemotherapy and radiation. The tumor was recurred at 4 months after surgical excision and with metastasis to the lung. The progress was characterized by an extremely rapid growth accompanied by distant metastasis. Surgery, irradiation and chemotherapy having no effect on the final outcome, the patient died 7 months after diagnosis.
Aged ; Contusions ; Diagnosis ; Drug Therapy ; Endothelial Cells ; Female ; Hemangiosarcoma* ; Hemorrhage ; Humans ; Liver ; Lung ; Male ; Neoplasm Metastasis ; Scalp* ; Skin ; Tomography, X-Ray Computed ; Transplants

Angiosarcoma is a rare malignant vascular tumor featuring endothelial cells. Angiosarcoma have four clinical manifestations that are angiosarcoma in the scalp and face, angiosarcoma in chronic lymphedematous areas, angiosarcoma in previously irradiated sites and malignant angioendothelioma. The most common lesions are those that occur in the scalp and in the face of elderly people. The male to female ratio is 2 : 1. In my case, a 65-years-old male presented progressively growing tumor on the left frontal scalp. The tumor began as an ill-defined bluish macule, which was initially mistaken for an old bruise. The rapidly growing lesion extended to form violaceousm compressible and hemorrhagic plaques. The mass was 6 x 4.5 cm in size. Distinguishing features are the frequent occurrence of a peripheral erythematous ring, satellite nodules, the presence of intratumoral hemorrhage, and the tendency to bleed spontaneously, or after minimal trauma. Histologically the tumor comprised anaplastic pleomorphic endothelial cells with new vascular channels and irregular vascular spaces lined by plump endothelial cell's stroma among them. The lesion was diagnosed as angiosarcoma. No metastasis to other organs were found as evaluated by chest CT, bone and liver scan. We performed wide excision, skin graft, bilateral transposition flap, chemotherapy and radiation. The tumor was recurred at 4 months after surgical excision and with metastasis to the lung. The progress was characterized by an extremely rapid growth accompanied by distant metastasis. Surgery, irradiation and chemotherapy having no effect on the final outcome, the patient died 7 months after diagnosis.
Aged ; Contusions ; Diagnosis ; Drug Therapy ; Endothelial Cells ; Female ; Hemangiosarcoma* ; Hemorrhage ; Humans ; Liver ; Lung ; Male ; Neoplasm Metastasis ; Scalp* ; Skin ; Tomography, X-Ray Computed ; Transplants

Paroxysmal itching is a rare symptom in multiple sclerosis and it was first reported in 1975 by Osterman and Westerberg. It has been suggested that paroxysmal itching may be due to the activation of axons in CNS via abnormal synapses between demyelinated axons. Carbamazepine, phenytoin, and ibuprofen are known to be effective in the treatment of paroxysmal itching. We report a case of paroxysmal itching of 4 months' duration in a 41-year-old female with multiple sclerosis who suffered from severe paroxysmal itching on the left side of her neck and chest. The itching did not respond to carbamazepine, but it was partially controlled with ibuprofen.
Adult ; Axons ; Carbamazepine ; Female ; Humans ; Ibuprofen ; Multiple Sclerosis* ; Neck ; Phenytoin ; Pruritus* ; Synapses ; Thorax

The role of forensic anthropology is to reconstruct the process of individual death by predicting the cause and manner of death as well as to find out biological profiles of unknown skeletal remains based on the data of physical anthropology. The purpose of this study is to suggest the data of decision-making process for cranial fractures and its related weapons of skeletal remains from the forensic fields. A hammer (31.7%) and baseball bat (16.7%) represented almost half of the blunt type of weapon used in the cranial fracture. The linear fracture was caused by most of weapons, the spider's web and depressed fracture by the hammer, and the comminuted fracture by the heavy tools such as maul, wrench, etc as well as the hammer. By the chi-square test, there were significant differences between fracture patterns and types of weapon that it was helpful to estimate the weapon of cranial fracture for forensic anthropological decisions. Conclusively, we could prepare the priority order of estimating cause and manner of death in the case of cranial fracture for the forensic context and suggest research design of physical anthropology about osteological biomechanics and taphonomy relating cranial fractures.
Anthropology, Physical ; Baseball ; Biomechanics ; Forensic Anthropology ; Fractures, Comminuted ; Research Design ; Skull ; Weapons