1.Clinical study on spinal muscular atrophies.
Soo Ahn CHAE ; Yong Seung HWANG
Journal of the Korean Pediatric Society 1992;35(12):1728-1736
No abstract available.
Muscular Atrophy*
2.A Case of Secondary Telangiectasia Associated with an Operation.
Nam Soo KIM ; Seung Hun LEE ; Sung Ku AHN
Korean Journal of Dermatology 1994;32(6):1103-1106
Telangiectasia is characterized by permanently dilated small vessels usually arising from the suprapapillary plexus of venule capillaries, or arterioles. It may be etvlogically divided into the primary and secondary types. Rosacea, varicose vein, prolonged sun xvsure, radiation, and physical trauma may be the causes of secondary telangiectasia. We report herein a case of secondary telangiectasia associated which operation for a femur fracture.
Arterioles
;
Capillaries
;
Femur
;
Rosacea
;
Solar System
;
Telangiectasis*
;
Varicose Veins
;
Venules
3.Comparison in Expression of CD 1 , HLA - DR and ICAM - 1 of Follicular Keratinocytes from a Lesion and a Non - Lesional Scalp of Alopecia Areata.
Won Soo LEE ; Sung Ku AHN ; Seung Hun LEE
Korean Journal of Dermatology 1995;33(5):873-879
BACKGROUND: Primary targit injured from the immunologic mechanism of alopecia areata is not definitely confirmed although alopecia areata is regarded as a disease occuring from certain im munologic process. Recently, par ticular interest has been focused on the follicular keratinocytes which show morphologic and anigenic alterations in active lesions. Another important point is the subclinical state hypothesi. It is based upon the observation that the patterns of T lymphocytes infiltration and ultrastructural changes of dermal papilla cells are nearly identical in active lesions and in non-lesional areas of alopecia areata. OBJECTIVE: The purpose of this study is to determine and to compare the aberrant expression of HLA-DR, CD1 and ICAM-1 on the follicular keratinocytes from the active alopecia areata lesion, stationary lesion and non-lesional scalp. METHODS: We performed a n immunohistochemical study, using the streptavidin system to compare the patterns of HLA-DR, CD1 and ICAM-1 immunoreactivity in the follicular keratinocytes in five active alopecia lesions two stationary lesions and non-lesional scalp specimens among four active and two stationary patients, and two normal control scalp specimens. RESULTS: In the active aloecia lesions, the HLA-DR and ICAM-1 immunoreactivity was observed in some patients while CD1 immunoreactivity was observed in all the patients. In the sta tionary alopecia lesions, none of the HLA-DR or CD1 or ICAM-1 immunoreactivity was observed as was the case in the norrial control scalp specimens. In the non-lesional normal scalp specimens, the HLA-DR, CD1 and ICAM-1 immunoreactivity showed nearly the same patterns as those in the acute alopecia leions. CONCLUSION: The aberrant antigenic alterations, especially CD1 expression of follicular keratinocytes are likely to be asociated with the active progress of alopecia areata lesions. These antigenic alterations were also observed in non-lesional scalp as well as alopecia areata lesions in the very similar patterns.
Alopecia Areata*
;
Alopecia*
;
HLA-DR Antigens
;
Humans
;
Intercellular Adhesion Molecule-1
;
Keratinocytes*
;
Scalp*
;
Streptavidin
;
T-Lymphocytes
4.Subtrochanteric Fracture Treated with Bent Self
In Ju LEE ; Myung Sang MOON ; Seung Soo AHN
The Journal of the Korean Orthopaedic Association 1984;19(2):351-356
Subtrochanteric fracture is well known for its difficulty in management, though various devices of rigid fixation have been developed. Each internal fixation device requires a lot of surgical instruments and the surgeon must be skillful in using them. Osteo self-compression plate which was preoperatively bent to fit the contour of the lateral surface of the subtrochanteric region was proved to be technically easy to fix these fractures without causing major complication. Present authors recommend to use this prebent Osteo self-compression device to treat this fracture when the surgical instruments are not fully equipped, and suitable fixation devices are not available, and/or the surgeon has no experience in handling the newly developed surgical instruments for the subtrochanteric fracture.
Internal Fixators
;
Surgical Instruments
5.Vitilligo Induced by Diphencyprone in a Patient with Alopecia Areata.
Soo Jung KIM ; Won Soo LEE ; Seung Hun LEE ; Sung Ku AHN
Korean Journal of Dermatology 1994;32(5):934-938
Common adverse effects due to topical therapy with DPCP(Diphenyprone) are severe contact dermatitis, dermographism, urticaria, generalized pruritus, lymphadenoiathy, and dermatitis on the remote areas. Rarely, DPCP can induce vitiligo or dyschromia in confetias side effects on the pigmentary system. It is not clear yet whither DPCP induced the vitiligcbatoxic effect of phenol ring in DPCP or by koebner phenomenon clue to repeated contact dermatitis in cases where vitiligo was in latent subclinical condition. We describe a patient with alopecia areatairho developed vitiligo due to topical therapy with DPCP. A 20-year-old woman developed alopecia areata with a loss of eye shows and eyelashes. After sensitization, DPCP was topically applieid to the scalp every week. Vitiligo, confirmed by electron microscopic study, appeared 4 month. after the beginning of treatment and was localized only to the areas of topical application. Both alogecia aieata and vitiligo are improving now under systemic and topical corticosteroid therapy.
Alopecia Areata*
;
Alopecia*
;
Dermatitis
;
Dermatitis, Contact
;
Eyelashes
;
Female
;
Humans
;
Phenol
;
Pruritus
;
Scalp
;
Urticaria
;
Vitiligo
;
Young Adult
6.Experimental Study of Calcinosis Cutis after Extravasation of Calcium Gluconate.
Kyun Tae KIM ; Soo Jung KIM ; Seung Hun LEE ; Sung Ku AHN ; Won Soo LEE
Korean Journal of Dermatology 1994;32(4):574-582
BACKGROUND: Neonatal hypocalcemia is not an infrequent condition, especially in the premature neonate. It is effectively treated by intravenous administration of calcium gluconate. Complications of extravasation during intraveous infusion included calcification and, occasionally necrosis. But the exact mechanism of calcinosis cutis following extravasation of calcium gluconate remains unknown and there is no specific mode of treatment except cold packs and skin graft. OBJECTIVE: Our purpose was to evaluate the clinical and histological features in rabbits after subcutaneous injection of 10% calcium gluconate and a mixed solution of gluconate and triamcinolone acetonide. METHODS: Two rabbits were divided into 3 groups and were subcutaneously injected with the following materials on the back; 10% calcium gluconate, a mixed solution of calcium gluconate and triamcinolone acetonide, and 25% normal saline as controls respectively. The injection site including the skin and subcutaneous fat was excised and fixed with natural buffered formalin. The biopsied specimens were stained with Hematolxylin and Eosin. RESULTS: 1) In the 10% calcium gluconate injected group, there was some erthema and induration after three days. By the fifth to the seventh days there was more erythema and firm induration. At 15 days, nodules and large ulcreated lesions developed. Multiple, linear shaped, ulcreative surfaced and indurated masses were noted at 37days.l from 45days to 2months there was progressive healing with decrease in ulceration, and gradual disapppearance of the mass. Histologically, at the 8th day calcium was seen in the walls of the arteries and veins, after 15days, the reaction was at its peak and epidermal necrosis was seen on the injected site. From 30 to 3days, calcium deposition and granuloma formation were seen in the dermis. In addition discharge of calcium deposits began to place by means of transepidermal elimination. After 45days, although the response was subsiding, the calcium and mucin deposition was observed focally in the dermis. 2. In the 10% calcium gluconate and triamcinolone acetonide adjuvant injected group, there was development of some erythema at 8days. After 15days, some erythema and induration were seen of the injected site ad this gradually disappeared. By 37days, the injection site was normal in appearance. Histologically, at 15days calcium deposition was seen on the upper dermis and the injection site was histologically normal after one month. 3. In 25% normal saline injected group, the injection site was clinically normal. Histologically there was no reaction except for focal perivascular eosinophilia after 24horus. CONCLUSION: We conclude that the important mechanism of calcinosis cutis appears to be elevated concentration as well as the tissue damage at the site of the extravasation of calcium gluconate. The final common pathway of calcification is the formation of crystalline and insoluble calcium phosphate mineral, in the form of hydroxyapatite. The intralesional injection of triamcinolone for the treatment of calcinosis cutis in our study was effective due to its antiinflammatory effect and the reabsorption of calcium in the tissues.
Administration, Intravenous
;
Arteries
;
Bowen's Disease
;
Calcinosis*
;
Calcium Gluconate*
;
Calcium*
;
Carcinoma, Squamous Cell
;
Crystallins
;
Dermis
;
Durapatite
;
Eosine Yellowish-(YS)
;
Eosinophilia
;
Erythema
;
Formaldehyde
;
Granuloma
;
Humans
;
Hypocalcemia
;
Infant, Newborn
;
Injections, Intralesional
;
Injections, Subcutaneous
;
Keratoacanthoma
;
Keratosis, Actinic
;
Mucins
;
Necrosis
;
Proliferating Cell Nuclear Antigen
;
Rabbits
;
Skin
;
Subcutaneous Fat
;
Transplants
;
Triamcinolone
;
Triamcinolone Acetonide
;
Ulcer
;
Veins
7.Experimental Study of Calcinosis Cutis after Extravasation of Calcium Gluconate.
Kyun Tae KIM ; Soo Jung KIM ; Seung Hun LEE ; Sung Ku AHN ; Won Soo LEE
Korean Journal of Dermatology 1994;32(4):574-582
BACKGROUND: Neonatal hypocalcemia is not an infrequent condition, especially in the premature neonate. It is effectively treated by intravenous administration of calcium gluconate. Complications of extravasation during intraveous infusion included calcification and, occasionally necrosis. But the exact mechanism of calcinosis cutis following extravasation of calcium gluconate remains unknown and there is no specific mode of treatment except cold packs and skin graft. OBJECTIVE: Our purpose was to evaluate the clinical and histological features in rabbits after subcutaneous injection of 10% calcium gluconate and a mixed solution of gluconate and triamcinolone acetonide. METHODS: Two rabbits were divided into 3 groups and were subcutaneously injected with the following materials on the back; 10% calcium gluconate, a mixed solution of calcium gluconate and triamcinolone acetonide, and 25% normal saline as controls respectively. The injection site including the skin and subcutaneous fat was excised and fixed with natural buffered formalin. The biopsied specimens were stained with Hematolxylin and Eosin. RESULTS: 1) In the 10% calcium gluconate injected group, there was some erthema and induration after three days. By the fifth to the seventh days there was more erythema and firm induration. At 15 days, nodules and large ulcreated lesions developed. Multiple, linear shaped, ulcreative surfaced and indurated masses were noted at 37days.l from 45days to 2months there was progressive healing with decrease in ulceration, and gradual disapppearance of the mass. Histologically, at the 8th day calcium was seen in the walls of the arteries and veins, after 15days, the reaction was at its peak and epidermal necrosis was seen on the injected site. From 30 to 3days, calcium deposition and granuloma formation were seen in the dermis. In addition discharge of calcium deposits began to place by means of transepidermal elimination. After 45days, although the response was subsiding, the calcium and mucin deposition was observed focally in the dermis. 2. In the 10% calcium gluconate and triamcinolone acetonide adjuvant injected group, there was development of some erythema at 8days. After 15days, some erythema and induration were seen of the injected site ad this gradually disappeared. By 37days, the injection site was normal in appearance. Histologically, at 15days calcium deposition was seen on the upper dermis and the injection site was histologically normal after one month. 3. In 25% normal saline injected group, the injection site was clinically normal. Histologically there was no reaction except for focal perivascular eosinophilia after 24horus. CONCLUSION: We conclude that the important mechanism of calcinosis cutis appears to be elevated concentration as well as the tissue damage at the site of the extravasation of calcium gluconate. The final common pathway of calcification is the formation of crystalline and insoluble calcium phosphate mineral, in the form of hydroxyapatite. The intralesional injection of triamcinolone for the treatment of calcinosis cutis in our study was effective due to its antiinflammatory effect and the reabsorption of calcium in the tissues.
Administration, Intravenous
;
Arteries
;
Bowen's Disease
;
Calcinosis*
;
Calcium Gluconate*
;
Calcium*
;
Carcinoma, Squamous Cell
;
Crystallins
;
Dermis
;
Durapatite
;
Eosine Yellowish-(YS)
;
Eosinophilia
;
Erythema
;
Formaldehyde
;
Granuloma
;
Humans
;
Hypocalcemia
;
Infant, Newborn
;
Injections, Intralesional
;
Injections, Subcutaneous
;
Keratoacanthoma
;
Keratosis, Actinic
;
Mucins
;
Necrosis
;
Proliferating Cell Nuclear Antigen
;
Rabbits
;
Skin
;
Subcutaneous Fat
;
Transplants
;
Triamcinolone
;
Triamcinolone Acetonide
;
Ulcer
;
Veins
8.Clinicopathologic Study of Pustular Drug Eruption.
Soo Jung KIM ; Seung Hun LEE ; Sung Ku AHN ; Won Soo LEE ; Beom Joo LEE
Korean Journal of Dermatology 1994;32(4):554-561
BACKGROUND: Pustular eruptions due to drugs are uncommonly reported. We studied the characteristics of clinical and histopathologic findings of pustular drug eruption. OBJECTIVE: We observed th.e causative agents, clinical featurs and histopathologic findings of pustular drug eruption and identified differential points of generlized pustular eruption. METHODS: We evaluated t,he clinical and histopathologic findings of 8 patients with pustular drug eruption and reviewed the literatures reported cases of pustular drug eruption. RESULTS: All patients diagnosed pustular drug eruption suffered from generalized pustular eruption associated with systemic symptoms such as fever, headachened myagia one to three days after treatment with causative agents. The causative agents of putular drug eruption are antibiotics such as ceftriaxone, analgesics and antipyretics. The pustule resolved after a few days of treatment with systemic corticosteroids and antihistamines. Laboratory findings revealed leukocytosis, neutrophilia, and analevated erythrocyte sedimentation rate, On histopatologic findings, we observed subcorneal pustuls containing neutrophils, eosinophils and some lymphocytes and spongiosis, exocytosis of acute iiflammatory cells. Perivascular infiltration of lymphocyte ancl edema of papillary dermis was also bserved in the dermis. CONCLUSION: Pustular drug eruption is characterized by generalized pustular eruption associated with systemic symptoms and histopathologic findings of that are sterile subcorneal pustules. Therefore differential diagnosis of other generalized pustular erupticns are relatively easy by careful history of medication, clinical and histopathologic findings.
Adrenal Cortex Hormones
;
Analgesics
;
Anti-Bacterial Agents
;
Antipyretics
;
Blood Sedimentation
;
Ceftriaxone
;
Dermis
;
Diagnosis, Differential
;
Drug Eruptions*
;
Edema
;
Eosinophils
;
Exocytosis
;
Fever
;
Histamine Antagonists
;
Humans
;
Leprosy
;
Leukocytosis
;
Lymphocytes
;
Neutrophils
9.Clinicopathologic Study of Pustular Drug Eruption.
Soo Jung KIM ; Seung Hun LEE ; Sung Ku AHN ; Won Soo LEE ; Beom Joo LEE
Korean Journal of Dermatology 1994;32(4):554-561
BACKGROUND: Pustular eruptions due to drugs are uncommonly reported. We studied the characteristics of clinical and histopathologic findings of pustular drug eruption. OBJECTIVE: We observed th.e causative agents, clinical featurs and histopathologic findings of pustular drug eruption and identified differential points of generlized pustular eruption. METHODS: We evaluated t,he clinical and histopathologic findings of 8 patients with pustular drug eruption and reviewed the literatures reported cases of pustular drug eruption. RESULTS: All patients diagnosed pustular drug eruption suffered from generalized pustular eruption associated with systemic symptoms such as fever, headachened myagia one to three days after treatment with causative agents. The causative agents of putular drug eruption are antibiotics such as ceftriaxone, analgesics and antipyretics. The pustule resolved after a few days of treatment with systemic corticosteroids and antihistamines. Laboratory findings revealed leukocytosis, neutrophilia, and analevated erythrocyte sedimentation rate, On histopatologic findings, we observed subcorneal pustuls containing neutrophils, eosinophils and some lymphocytes and spongiosis, exocytosis of acute iiflammatory cells. Perivascular infiltration of lymphocyte ancl edema of papillary dermis was also bserved in the dermis. CONCLUSION: Pustular drug eruption is characterized by generalized pustular eruption associated with systemic symptoms and histopathologic findings of that are sterile subcorneal pustules. Therefore differential diagnosis of other generalized pustular erupticns are relatively easy by careful history of medication, clinical and histopathologic findings.
Adrenal Cortex Hormones
;
Analgesics
;
Anti-Bacterial Agents
;
Antipyretics
;
Blood Sedimentation
;
Ceftriaxone
;
Dermis
;
Diagnosis, Differential
;
Drug Eruptions*
;
Edema
;
Eosinophils
;
Exocytosis
;
Fever
;
Histamine Antagonists
;
Humans
;
Leprosy
;
Leukocytosis
;
Lymphocytes
;
Neutrophils
10.Longitudinal Melanonychia due to Candida Species.
In Wook LEE ; Eung Ho CHOI ; Won Soo LEE ; Seung Hun LEE ; Sung Ku AHN
Annals of Dermatology 1998;10(4):281-284
A 55-year-old Korean female patient who presented with longitudinal black pigmentation affecting the right thumbnail is described. Direct microscopic examination of nail tissue in 15% potassium hydroxide and cultures on Sabourauds glucose agar revealed Candida species. Cardida species as a cause of longitudinal melanonychia has, to our knowledge, been described only once in the literature. Our case may be the second one.
Agar
;
Candida*
;
Female
;
Glucose
;
Humans
;
Middle Aged
;
Pigmentation
;
Potassium