There are many factors which cause postoperative hepatic dysfunction or necrosis: chronic liver disease, viral infection, septicemia, severe burn, nutritional deficiency, previous or concommitant drug therapy, hypoxia, hypercarbia, hypotension and surgical procedures. Anesthetic agents are not the most common cause of postoperative hepatic dysfunction. But too frequently halothane is blamed for postoperative hepatic dysfunction, while other more likely causes are ignord. So, in order to in vestigate the effects of halothane, enflurane and thalamonal anesthesia on hepatic function, we compared with serum GOT, GPT level at preoperatively and postoperatively in 60 patients who had no liver disease previously and had no experience of general anesthesia. We divided them randomly in 3 groups: halothane administered group, enflurane administered group and thalamonal administered group. And serum GOT, GPT were checked preoperatively, postop, 24 hrs, and on postop, 6th day. Blood transfusion were not performed during this study. The result of this study reveals that there is no statistically significant difference in changes of SGOT, SGPT between halothane, enflurane and thalamonal group during postoperative period(p>0.05). This result show that the effect of halothane on hepatic function was not significantly different from those of enflurane and thalamonal.
Alanine Transaminase* ; Anesthesia* ; Anesthesia, General ; Anesthetics ; Anoxia ; Aspartate Aminotransferases* ; Blood Transfusion ; Burns ; Drug Therapy ; Enflurane* ; Halothane* ; Humans ; Hypotension ; Liver Diseases ; Malnutrition ; Necrosis ; Sepsis