2.A clinical investigation of new diuretics, azosemide(SK-110).
Young Tai SHIN ; Sunn Kgoo RHEE ; Min Soo JEONG ; Seung Hun SHIN ; Gang Wook YI
Korean Journal of Nephrology 1992;11(1):33-39
No abstract available.
Diuretics*
3.A study of complications related to subclavian catheters for hemodialysis.
Yung Tai SHIN ; Seung Hun SHIN ; Min Soo JEONG ; Sunn Kgoo RHEE ; Jeong Ho LEE ; Gang Wook YI
Korean Journal of Nephrology 1991;10(3):372-378
No abstract available.
Catheters*
;
Renal Dialysis*
4.Treatment Options for Lower Ureteral Calculi: Expectancy or Endourologic manipulations.
Korean Journal of Urology 1995;36(8):874-880
To determine the optimal therapeutic approach for lower ureteral calculi at the hospitals which have not possessed ESWL, we reviewed 85 cases initially treated with expectancy for more than 7 days. Of 85 cases, 37 were treated with expectancy only and the remaining 48 cases received the endourologic manipulations such as stone basket and ureteroscopic removal. A total cumulative spontaneous passage rate at 3 weeks was about 52.9% and the possibility of spontaneous passage of remained stones at 3 weeks was not significant. The spontaneous passage rate was higher in the cases with the stones of small size (less than 6mm), smooth-round shape and without urinary tract obstruction than the other cases. 26 cases were treated with the stone basket and stone extraction rate was only 42.3%. The stone extraction rate was higher in the cases with the stones of smaller size (less than 4mm), irregular-speculated shape and with short duration of previous expectancy than the other cases. A total of 32 cases received the ureteroscopic manipulation and the success rate was 87.5%. Thus, we recommend initial expectancy for up to 3 weeks in the lower ureteral calculi smaller than 10 mm. And after this period, the positive and selective endourological manipulation considering the stone size, shape and expectant duration may be desirable in respect of treatment efficacy.
Treatment Outcome
;
Ureter*
;
Ureteral Calculi*
;
Urinary Tract
5.Utility of Acetazolamide - Enhanced Brain Perfusion SPECT in Predicting Outcome of the Patients with Aneurysmal Subarachnoid Hemorrhage.
Yun Young CHOI ; Jae Min KIM ; Kwang Myung KIM ; Il Seung CHOE ; Suk Shin CHO
Korean Journal of Nuclear Medicine 2001;35(4):241-250
No abstract available.
Acetazolamide*
;
Aneurysm*
;
Brain*
;
Humans
;
Perfusion*
;
Subarachnoid Hemorrhage*
;
Tomography, Emission-Computed, Single-Photon*
6.The Effect of Systemic PUVA on the Proliferation of Melanocytes and the Titer of Anti - Pigment Cell Autoantibodies in Vitiligo Patients.
Seung Kyung HANN ; Hang Kye SHIN ; Min Seok SONG ; Yoon Kee PARK
Korean Journal of Dermatology 1997;35(1):57-70
BACKGROUND: PUVA has been used effectively in the treat,ment of vitiligo, but the mechanism by which PUVA stimulat.es melanocyte proliferation in vitiligo is not known. Several mechanisms have been suggested to be involved in the process of repigmentation of vitiligo. First, UV light, with or without psoralen, directly stimulates the proliferation of melanocytes. Secondly, PUVA may act. on epidermal keratinocytes or dermal components to stimulate t,hem to release certain melanocyte growth st,inulation factors that enhance the proliferation of melanocytes in depigmented lesions. Thirdly, PUVA irnmunologically leads to the impairment of epidermal Langerhans cell function and alteration of circulating T and B cell function, which results in the suppression of the stimuli is for rnelanocyte destruction during the therapy. OBJECTIVE: To test, th hypothesis that PUVA induced repigmentation in vitiligo results from the stimulation of growth factors that induce melanocyte proliferation, and that PUVA may suppress the immune reacticin to melanocytes, especially in autoantibody synt,hesis, we examined the effects of sera on the growth of epidermal melanocytes and control cells, and t,he incidence of antibodies to melanocyte and melanoma cells(SK-Mel 2~3) in the sera of patients with vitiligo. We also had normal control individuals and studied the changes of the antibody titer in the sera of patients with vitiligo. METHODS: The rate of H thymidine uptake was estimat,ed in cultured melanocytes and fibroblasts t,reated by patients sera before and after PUVA treatment. SDS-PAGE and immunoblotting analysis were used to idcntify anti pigment cell autoantibodies and were compared to the titers of autoantibodies after PUVA. RESULTS: 1. Melanocyte and fibrablast proliferation was increased by PUVA treated sera. Their proliferation was in proportion to the duration of the PUVA treatment. Melanocytes proliferated more than fibroblasts. 2. Significant differences between vitiligo patients and normal controls were found in the inci dence of anti-pigment cell antibodies. The antibodies were predominantly directed to melanocyte antigens of 110 kD, 65 kD, 45 kD and melanoma cell antigens of 110 kD, 103 kD, 88kD, 70 kD, 56 kD, 41 kD. 3. The titer of anti piment cell antibodies showed a tendency to decrease after PUVA treat- ment in most patients regardless of clinical improvement. Conclusion ; PUVA treated sera induced proliferation of melanocytes and fibroblasts and the production of aut,oantibodies was suppressed against pigment cell antigens through irnmunosuppression, which might help in the repigmentation of vitiligo.
Antibodies
;
Autoantibodies*
;
Electrophoresis, Polyacrylamide Gel
;
Fibroblasts
;
Ficusin
;
Humans
;
Immunoblotting
;
Incidence
;
Intercellular Signaling Peptides and Proteins
;
Keratinocytes
;
Melanocytes*
;
Melanoma
;
Thymidine
;
Ultraviolet Rays
;
Vitiligo*
7.The Effect of Systemic PUVA on the Proliferation of Melanocytes and the Titer of Anti - Pigment Cell Autoantibodies in Vitiligo Patients.
Seung Kyung HANN ; Hang Kye SHIN ; Min Seok SONG ; Yoon Kee PARK
Korean Journal of Dermatology 1997;35(1):57-70
BACKGROUND: PUVA has been used effectively in the treat,ment of vitiligo, but the mechanism by which PUVA stimulat.es melanocyte proliferation in vitiligo is not known. Several mechanisms have been suggested to be involved in the process of repigmentation of vitiligo. First, UV light, with or without psoralen, directly stimulates the proliferation of melanocytes. Secondly, PUVA may act. on epidermal keratinocytes or dermal components to stimulate t,hem to release certain melanocyte growth st,inulation factors that enhance the proliferation of melanocytes in depigmented lesions. Thirdly, PUVA irnmunologically leads to the impairment of epidermal Langerhans cell function and alteration of circulating T and B cell function, which results in the suppression of the stimuli is for rnelanocyte destruction during the therapy. OBJECTIVE: To test, th hypothesis that PUVA induced repigmentation in vitiligo results from the stimulation of growth factors that induce melanocyte proliferation, and that PUVA may suppress the immune reacticin to melanocytes, especially in autoantibody synt,hesis, we examined the effects of sera on the growth of epidermal melanocytes and control cells, and t,he incidence of antibodies to melanocyte and melanoma cells(SK-Mel 2~3) in the sera of patients with vitiligo. We also had normal control individuals and studied the changes of the antibody titer in the sera of patients with vitiligo. METHODS: The rate of H thymidine uptake was estimat,ed in cultured melanocytes and fibroblasts t,reated by patients sera before and after PUVA treatment. SDS-PAGE and immunoblotting analysis were used to idcntify anti pigment cell autoantibodies and were compared to the titers of autoantibodies after PUVA. RESULTS: 1. Melanocyte and fibrablast proliferation was increased by PUVA treated sera. Their proliferation was in proportion to the duration of the PUVA treatment. Melanocytes proliferated more than fibroblasts. 2. Significant differences between vitiligo patients and normal controls were found in the inci dence of anti-pigment cell antibodies. The antibodies were predominantly directed to melanocyte antigens of 110 kD, 65 kD, 45 kD and melanoma cell antigens of 110 kD, 103 kD, 88kD, 70 kD, 56 kD, 41 kD. 3. The titer of anti piment cell antibodies showed a tendency to decrease after PUVA treat- ment in most patients regardless of clinical improvement. Conclusion ; PUVA treated sera induced proliferation of melanocytes and fibroblasts and the production of aut,oantibodies was suppressed against pigment cell antigens through irnmunosuppression, which might help in the repigmentation of vitiligo.
Antibodies
;
Autoantibodies*
;
Electrophoresis, Polyacrylamide Gel
;
Fibroblasts
;
Ficusin
;
Humans
;
Immunoblotting
;
Incidence
;
Intercellular Signaling Peptides and Proteins
;
Keratinocytes
;
Melanocytes*
;
Melanoma
;
Thymidine
;
Ultraviolet Rays
;
Vitiligo*
8.Detection of Genital Human Papilloma Viruses Using PCR.
Kyoung Chan PARK ; Seung Yong JUNG ; Young Min CHOI ; Seon Hoon KIM ; Yoo Shin LEE
Annals of Dermatology 1991;3(1):37-39
Fifteen cases of genital warts were examined for the presence of human papillomavirus (HPV) using polymerise chain reaction (PCR). HPV6/11 DNA were found in all cases of genital warts. The PCR based methods described here provide a sensitive, accurate means of detecting genital HPVs.
Condylomata Acuminata
;
DNA
;
Humans*
;
Papillomaviridae*
;
Polymerase Chain Reaction*
9.A clinical study of congenital anomalies in births associated with hydramnios.
Eun Sil SHIN ; Min Jeong KIM ; Ock Seung JEONG ; Song Sang SEO
Journal of the Korean Pediatric Society 1993;36(9):1227-1235
A study was made in the congenital anomalies in 137 babies born to 120 mothers with hydramnios, delivered at Ilsin Christian Hospital between Jan. 1st 1981 and Dec. 31th 1990. The results were as follows; 1) The incidence of hydramnios was 1.6/1000 deliveries, 120 cases in total 73, 129 deliveries. 137 infants was born and of these 71 (51.8%) had congenital anomalies. 2) Hydramnios was assiciated with a high incidence of prematurity and low birth weight infant. 3) The incience of multiple anomalies was 54.9% (39 out of 71 infants). The most common system involved with the congenital anomalies was the musculoskeletal system, 28.9% (39 cases out of 135) and the most frequent anomaly was anencephaly, 15 cases. 4) The perinatal mortality rate was 759/1000 total (104 cases) and of these 45 cases, 43.3% were associated with congenital anomalies. 53 of the live birth had congenital anomalies and of these 27 cases (50.9%) died in the neonatal period.
Anencephaly
;
Humans
;
Incidence
;
Infant
;
Infant, Low Birth Weight
;
Infant, Newborn
;
Live Birth
;
Mothers
;
Musculoskeletal System
;
Parturition*
;
Perinatal Mortality
;
Polyhydramnios*
10.Epidural Granulocytic Sarcoma Causing Cord Compression at Thoracic Region in Acute Myelogenous Leukemia: A Case Report.
Woo Min PARK ; Jee Soo JANG ; Chang Hun RHEE ; Ho Shin GWAK ; Seung Hoon LEE
Journal of Korean Neurosurgical Society 2000;29(11):1533-1537
No abstract available.
Leukemia, Myeloid, Acute*
;
Sarcoma, Myeloid*