1.A Case of Fluoxetine-induced Mania & Suicidal Ideation in Obsessive-Compulsive Disorder.
Journal of the Korean Society of Biological Psychiatry 1999;6(2):253-258
The fluoxetine is one of the most frequently prescribed drugs for the treatment of depression and obsessive-compulsive disorder(OCD). This has been know as one of the most safest medication. But since the advent of this drug, there have been several reports of side effects-the mania and suicidal ideation-encountered during coadministration of fluoxetine with or without other psychotropic drugs. We experienced a case of 20 years old male OCD patient who developed into abrupt manic state and also was preoccupied with intense suicidal ideation following fluoxetine use. He was a only child in his family and his father had a history of alcoholism about 15 years ago. Our patient's obsessive-compulsive symptoms have been occured since puberty. His OCD symptoms and anxiety were aggravated since joining the army. Beside these facts, we could not find any other psychiatric history such as depressive disoder and bipolar disorder. We used the fluoxetine starting dosage of 20mg and increased to 40mg at second week. About 3 weeks after the treatment, he developed sudden manic symptom and more aggravated suicidal ideation without any OCD symptoms. He felt vitalized and energetic without having enough sleep and food. These symptoms were ceased over two weeks by stopping medication. Up to this point, the reason why fluoxetine induces mania and suicidal preoccupation is unclear. But somehow the fluoxetine has effects on serotonin receptor and serotonin-dopamine regulations, thus we could make an assumption that fluoxetine can induce mania, extrapyramidal symptoms(EPS) and suicidal ideation in some part of the serotonin unbalanced patients. We think this would be the first report to remark on fluoxetine's suicidal and manic side effects in Korea. So here we present the case with the summary of reviewed articles.
Adolescent
;
Alcoholism
;
Anxiety
;
Bipolar Disorder*
;
Depression
;
Fathers
;
Fluoxetine
;
Humans
;
Korea
;
Male
;
Obsessive-Compulsive Disorder*
;
Only Child
;
Psychotropic Drugs
;
Puberty
;
Serotonin
;
Social Control, Formal
;
Suicidal Ideation*
;
Suicide
;
Young Adult
2.Localized Idiopathic Lipoatrophy Showing Involutional Histopathology.
Seung Min LEE ; Sung Ku AHN ; Seung Hun LEE
Annals of Dermatology 1994;6(2):200-203
We present cases of localized idiopathic lipoatrophy occurring in two women. A 19-year-old girl had symmetrically distributed annular telangiectatic atrophy on both buttocks and a 44-year-old female had annular telangiectatic atrophy on the right buttock. The histopathologic findings of these lesions revealed numerous capillaries, various sized lobules with small round or spindle shaped cells on a background of hyaline material in subcutaneous layer. Two cases of lipoatrophy which shows the involutional phase are reported.
Adult
;
Atrophy
;
Buttocks
;
Capillaries
;
Female
;
Humans
;
Hyalin
;
Young Adult
3.A Case of Connective Tissue Nevi: Elastocollagenoma compared with Elastofibroma.
Seung Min LEE ; Won Hyung KANG ; Seung Hun LEE
Annals of Dermatology 1994;6(2):230-235
No abstract available.
Connective Tissue*
;
Nevus*
4.Spitz Nevus with Atypical Clinical Features in a Baby.
Korean Journal of Dermatology 2017;55(3):210-211
No abstract available.
Nevus, Epithelioid and Spindle Cell*
5.Conservative surgery and radiation therapy in the treatment of stage I and II breast cancer.
Journal of the Korean Cancer Association 1992;24(1):125-129
No abstract available.
Breast Neoplasms*
;
Breast*
6.The Significance of Interleukin-6 in Henoch-Schonlein Purpura Nephritis in Children.
Min Joong KWON ; Jae Seung LEE
Journal of the Korean Society of Pediatric Nephrology 1997;1(2):130-135
Carcinsarcoma is an uncommon pulmonary malignancy characterized by carcinmatous parenchyma and sarcomatous stroma. The cytologic, immunohistochemical and ultrastructural features of a case of pulmonary carcinosarcoma suspected by fine needle aspiration cytology is presented. Only bizarre spindle cells arranged in loose groups, in microtissue fragments and in a dissociate fashion were present in the aspiration smears. They were markedly positive for vimentin. The epithelial component was not found, which was probably due to marked paucity of carcinomatous component that was proved by histologic examination of the resected tumor. The diagnosis of pulmonary carcinosarcoma should be conidered whenever poorly differentiated epithelial cell groups with a malignant mesenchymal component set in a myxoid background are seen in a pulmonary cytology specimen.
Biopsy, Fine-Needle
;
Carcinosarcoma
;
Child*
;
Diagnosis
;
Epithelial Cells
;
Humans
;
Interleukin-6*
;
Nephritis*
;
Purpura, Schoenlein-Henoch*
;
Vimentin
7.Allelic Association of the Dopamine D4 Receptor Gene in Korean Alcoholism.
Journal of the Korean Society of Biological Psychiatry 2001;8(2):246-250
The dopamine D4 receptor gene has a hypervariable segment in the coding region charcterized by a varying number of 48bp repeats in exon III of the gene. Varying the numbers of repeated segments may change the length, structure, and function of the receptor, which makes this gene a possible candidate for variations in dopamine-related behaviors. such as alcoholism and drug abuse. We evaluated the dopamine D4 receptor genotype in male alcoholics and normal controls. All alcoholics and controls were unrelated and from the Korean population. Genotype and allele frequencies in 67 alcoholics were compared to 67 controls who were free of alcohol abuse. substance abuse. and major mental illness. No association was found between the dopamin D4 recepto allele and alcoholism. This result indicate that there is no association of the dopamine D4 receptor with alcoholism in Korean. Further systemized investigation to determine the role of dopamine D4 receptor gene in alcoholism with a larger sample size will be required.
Alcoholics
;
Alcoholism*
;
Alleles
;
Clinical Coding
;
Dopamine*
;
Exons
;
Gene Frequency
;
Genotype
;
Humans
;
Male
;
Receptors, Dopamine D4*
;
Sample Size
;
Substance-Related Disorders
8.The Association Between Lung Function and Type 2 Diabetes in Koreans
Osong Public Health and Research Perspectives 2020;11(1):27-33
This study was performed to test the association between lung function and type 2 diabetes mellitus (T2DM) in Korean patients. Data from the 6th Korea National Health and Nutrition Examination Survey (2013 to 2015) was used in this study. There were 3,466 individuals aged between 40 and 80 years, with T2DM, who had a smoking and alcohol status listed, and blood analysis (including blood pressure), were included in this study. Lung function, measured by spirometer ventilatory dysfunction was categorized into 3 patterns: normal, restrictive ventilatory dysfunction, and obstructive ventilatory dysfunction (OVD). Based on multivariate logistic regression analysis, individuals with restrictive ventilatory dysfunction had an increased odds ratio (OR 1.615, 95% CI 1.137–2.294) for T2DM compared with individuals with normal ventilatory function, whereas OVD had no increase in the odds ratio (OR 1.169, 95 % CI 0.857–1.594). Model 1, which adjusted for age and gender, showed that the probability of having restrictive disorder was 1.559 times (95% CI 1.617–2.082) higher for prediabetes patients, and 2.320 times (95% CI 1.611–3.343) higher for T2DM patients, compared to normal individuals. For Model 4, which was fully adjusted for variables, the probability of having a restrictive disorder was 1.837 times higher for T2DM patients (95% CI 1.260–2.679). Restrictive ventilatory dysfunction, but not OVD, was associated independently with T2DM.
9.The Study on the Effects of Psoralen Derivatives on Epidermal Melanocytes in C57 BL Mice after Topical Photochemotherapy.
Seung Min LEE ; Seung Kyung HANN ; Yoon Kee PARK
Annals of Dermatology 1994;6(1):1-8
BACKGROUND: Monofunctional psoralens plus UVA radiation are not severely phototoxic and have less mutagenic activity than bifunctional psoralens plus UVA radiation. OBJECTIVE: The purpose of this study was to evaluate pigment producing effect using various concentrations(0.02%, 0.1%, 0.5%) of monofunctional psoralens such as angelicin, khellin and comparing it's effect with TMP in topical photochemotherapy. METHOD: Ninty three C57BL mice were painted with either angelicin, khellin or TMP solution in concentrations of 0.02%, 0.1% and 0.5% each and were UVA irradiated. Skin biopsies were performed at 1,3,5 weeks after UVA irradiation. The pigment producing effects were measured by the number, area and perimeter of the melanocytes after topical PUVA. RESULTS: The comparison of melanocyte numbers between different psoralens after five weeks of photochemotherapy showed a significant difference in decreasing order of TMP, khellin and angelicin. The area and perimeter of melanocytes were larger in the TMP group after five weeks photochemotherapy than the other group. However in the khellin and angelicin group, the area and perimeter of melanocytes were not increased by increasing the frequency of the UVA irradiation. CONCLUSION: The number, area and perimeter of melanocytes after topical PUVA increased in the TMP group compared to angelicin or khellin group. We expect the clinical application of angelicin and khellin in vitiligo is possible considering the result of the study of pigment producing effect with a higher concentration and higher dose of UVA.
Animals
;
Biopsy
;
Ficusin*
;
Furocoumarins
;
Khellin
;
Melanocytes*
;
Methods
;
Mice*
;
Mice, Inbred C57BL
;
Paint
;
Photochemotherapy*
;
Skin
;
Thymidine Monophosphate
;
Vitiligo
10.Clinical Features and Histopathological Characteristics of Nevus Depigmentosus.
Han Seung LEE ; Soo Min KIM ; Seung Kyung HANN
Korean Journal of Dermatology 1998;36(1):86-94
BACKGROUND: Nevus depigmentosus was first reported in 1884 by Lesser. It is defined as a congenital non-progressive hypopigmented macule or patch that is stable in its relative size and distribution throughout the life of the individual. The etiopathogenesis and histopathological characteristics of nevus depigmentosus are not fully established. OBJECT: The purpose of this study is to investigate the clinical and histopathological characteristics and pathogenesis of nevus depigmentosus. METHODS: Clinieal survey was carried out on forty-nine patients with nevus depigmentosus and two skin biopsies were taken from eighteen patients; from the central part of the depigmented lesion and the border of the lesion including the perilesional normal skin. The sections were stained with hematoxylin-eosin, Fontana-Masson and S-100 protein. The ultrastructural evaluation were also done to detect alternation of melanocytes. RESULTS: The results are as follows ; 1. The lesions were mostly (91.8%) present before the age of three, but some lesions appeared in childhood (8.2%). 2. The lesions were most frequently found on the trunk (42.9%), followed by the face and scalp (20.4%). 3. There were 33 patients (67.3%) with the isolated type, 15 patients (30.6%) with the dermatomal type and one patient with the whorled type. 4. Histopathological studies have shown that the stainability of Fontana-Masson in the lesions of nevus depigmentosus was decreased compared with perilesional nomal skin, but there were no changes in the number of melanocytes. 5. There was a great reduction in the number of melanosomes in melanocytes and keratinocytes of nevus depigmentosus. In keratinocytes, there was some aggregations of melanosomes and some of them showed membrane bound architecture. CONCLUSION: The results of this study support the fact that nevus depigmentosus is caused by functional defects of melanocytes and morphological abnonnalities of melanosomes.
Biopsy
;
Humans
;
Keratinocytes
;
Melanocytes
;
Melanosomes
;
Membranes
;
Nevus*
;
S100 Proteins
;
Scalp
;
Skin