Cavernous malformation(CM) is one of the most common intracranial vascular anomaly. CM have dynamic lesion behavior and various clinical spectrum. Hemorrhagic risk and neurological disability seem to be related to multiple factors, including lesion location, age, gender, state of the reproductive cycle, and previous hemorrhage. Selecting the best treatment modality, each clinical scenario requires the proposal of a distinct management approach aimed at weighing the treatment risk against the best estimate of the cumulative natural risk. Management strategies include expectant follow-up in patients with asymptomatic or inaccessible lesions and microsurgical excision of symptomatic and accessible lesions. Radiosurgery could be applied for the progressively symptomatic lesions in inoperable locations, but the mortality and morbidity due to recurrent hemorrhage during latency period and radiation injury should be concerned.
Follow-Up Studies ; Hemorrhage ; Humans ; Latency Period (Psychology) ; Mortality ; Natural History ; Radiation Injuries ; Radiosurgery ; Risk Management

The authors performed prospectively the transcranial Doppler monitoring of bilateral anterior and middle cerebral arteries in 15 patients with ruptured cerebral aneurysm. The entry criteria for the study were confined to the patients who were admitted within 3 days after bleeding and had clinical grades of I, II, or III. The mean frequency shifts of bilateral anterior and middle cerebral arteries were increased immediately after ictus and showed continous further elevation between the 3rd and 8th rupture days. After that, they normalized slowly. The increase of frequency shift preceded clinical ischemic symptoms and an early steep increase of frequency shift was correlated to a high chance for suffering delayed ischemic deficits. The thick clots in subarachnoid cisterns shown on CT scans taken within the third rupture day were correlated well to the severe increase of frequency shifts. The aggressive treatment was done on asymptomatic patients who showed relatively rapid increase of frequency shifts, and they had shown no or trasient mild ischemic symptoms.
Hemorrhage ; Humans ; Intracranial Aneurysm* ; Middle Cerebral Artery ; Prospective Studies ; Rupture ; Tomography, X-Ray Computed

The effect of the calcium antagonist nimodipine on the feline cerebral cortical blood flow in experimentally induced subarachnoid hemorrhage(SAH) was studied. Cerebral cortical blood flow was measured in the middle cerebral territory at specified intervals by the hydrogen clearance method. SAH was induced in 25 cats by a slow injection of fresh autogenous arterial blood into the cisterna magna. Twenty-five cats were divided into 5 groups of 5 cats each according to the timing of the cerebral cortical blood flow measurements after SAH ; immediate(Group la, lb), 24 hours(Group 2), 48 hours(Group 3) and 7 days (Group 4). Cerebral cortical blood flow dereased by 55.5%, 39.2%, 41.4%, and 38.3% from pre-SAH levels in each group respectively. During nimodipine infusion(1 microgram/kg/min) cerebral cortical flow increased by 89.0%, 51.8%, 87.5% and 24.5% from pre-nimodipine infusion levels in each group respectively. Mean arterial blood pressure(MABP) after cisternal blood injection increased by 6.5% from pre-SAH levles, and MABP during nimodipine infusion decreased by 15.4% from pre-Nimodipine infusion levels. The calcium antagonist nimodipine increased cerebral cortical blood flow significantly in experimentally induced SAH without considerable changes of MABP. Results are considered promising for trials in the treatment and prevention of cerebral by vasospasm following SAH.
Animals ; Calcium* ; Cats ; Cisterna Magna ; Hydrogen ; Nimodipine* ; Subarachnoid Hemorrhage*

The microsurgical anatomy of the middle cerebral artery(MCA) was reviewed. Embryology, segments, major branches, perforating branches, anomalies of the MCA and the anatomy of the Sylvian fissure were summarized.
Embryology ; Middle Cerebral Artery*

A 27-year-old woman with a clavicular fracture and post-traumatic hydrocephalus developed a subclavicular pseudomeningocele which was successfully treated by lumboperitoneal shunt. A brief review of the neurosurgical literature on the management of pseudomeningocele is presented.
Adult ; Female ; Humans ; Hydrocephalus

Microsurgical clipping is a standard treatment modality of cerebral aneurysms. Despite the far advances in surgical technique and craft, aneurysm surgery is still challenge to neurosurgeons. It carries considerable risk of mortality and morbidity to the patient unless the surgeon keeps the basic principles and tactics for accurate placement of aneurysm clip. To attain the goal of complete isolation of aneurysm from the cerebral circulation with concurrent saving parent artery and critical perforators, safe exposure of aneurysm, proper clip selection and accurate placement of the clip should be necessary. From exposure of target aneurysm to the final clip application, the authors will describe notable considerations for the successful clipping of aneurysm based on their own experience and review of literature.
Aneurysm ; Arteries ; Humans ; Intracranial Aneurysm* ; Mortality ; Parents

Only about 15% of intracranial aneurysms involve the posterior circulation and about 80% of distal basilar aneurysms have their origin at the level of or above the posterior clinoid process. Therefore, they are potentially approachable via the pterional or trans-sylvian route. This imply that most neurosurgeons will relatively rarely be required to perform this procedure. Especially basilar bifurcation aneurysms arising substantially below the level of the posterior clinoid process or projecting posteriorly could be successfully repaired via subtemporal approach. There are number of unique surgical problems that can be best attacked through a subtemporal approach, and for this reason it is important to have facility with its performance and a detailed understanding of its advantages and limitations. Surgical tactics and pitfalls of subtemporal approach will be described with a basis of experiences in Yonsei University and review of literatures.
Aneurysm ; Intracranial Aneurysm*

The authors measured flow velocity of intracranial arteries to venrify the patency of the parent arteries and branches after clip placement during aneurysm surgery. Before the clinical study, experimental sonographic recording was done with a feline aorta. The patency was evaluated by recording the flow velocity and pulse waveform using intraoperative microvascular Doppler sonography. The results of the clinical study were summarized as follows: (1) The patency of the parent artery can be proved. (2) The complete clipping of aneurysmal sac can be confirmed. (3) Vasospasm or narrowing of the arterial caliber can be detected. (4) Severe arteriosclerosis may mimic decreased flow velocity. It is suggested that the use of intraoperative microvascular Doppler sonography is an atraumatic and reliable method of testing the optimal clipping of the aneurysm and patency of the parent artery.
Aneurysm ; Aorta ; Arteries ; Arteriosclerosis ; Humans ; Intracranial Aneurysm* ; Parents ; Ultrasonography

A case of pituitary tuberculoma in a 53-year-old male is reported. His clinical complaints included headache and right ptosis. Endocrinological studies showed hypopituitarism. Radiologic studies showed enlargement of the sellar turcica. Removal of the tumor resulted in resolution of his neurological symptoms and signs.
Headache ; Humans ; Hypopituitarism ; Male ; Middle Aged ; Tuberculoma*

The author analyzed 169 cases of spontaneous intracerebral hemorrhages at the basal ganglia and thalamus, who had been admitted to Jeonju Presbyterian Medical Center from 1975 to 1979. Intracerebral hematoma was confirmed by angiography and the amount of hematoma was divided as small, medium or large according to the angiographic evidence. Among the 169 cases, 145 cases underwent appropriate medical or surgical treatment. 63 cases were treated conservatively and 82 cases were operated ; 22 cases of frontal approach, 51 cases of temporal approach, and 9 cases of extraventricula diainage of clot. Results obtained are as follows : 1. The common pridiection age group was from the fifth to the seventh decades, which was 90.5% of all cases. The ratio of male to female was about 2 to 1. 2. putaminal hemorrhage was 65.1%, and thalamic hemorrhage was 16.6%. 3. Angiographic evidence of arteriosclerosis was seen in 86.4%. 4. The worse prognostic factors were related to age(over 65), site and size of hematoma, and mental state on admission. 5. With conservative management 49.2% were improved, 6.3% not improved, 44.4% moribund or dead. 6. With surgical treatment 58.5% were improved, 3.7% not improved, 37.8% moribund or dead. 7. Microsurgical temporal approach proved to have the following advantages over frontal approach. (1) Better outcome was found in this approach(64.7% vs 54.4%). (2) The distance to the hematoma was closer in temporal approach, and so total removal of hematoma and complete control of bleeding sources with less surrounding structural damages were possible. 8. Early operation seems to be more effective than delayed operation in the cases of large hematoma with deteriorating neurological signs.
Angiography ; Arteriosclerosis ; Basal Ganglia* ; Cerebral Hemorrhage* ; Female ; Hematoma ; Hemorrhage ; Humans ; Jeollabuk-do ; Male ; Protestantism ; Putamen ; Putaminal Hemorrhage ; Thalamus*