No abstract available.
Drug Therapy* ; Ovarian Neoplasms*

Treatment of pelvic malignancy persistent or recurrent after surgery, radiation therapy or chemot-herapy presents a difficult therayeutie challenge. Those patients with central recurrence can be considered as candidate for radical resection. However we must consider many factors for the choice of treatment modality for advanced or recurrent pelvic rnalignancy as follows; the size and location of the recurrent cancer, dose of radiation therapy given, general conditions of the patient and the experience of the surgeon. Pelvie exenteration, when appropriate, is suecessful treatment for recurrent or persistent pelvic malignancy; 5-year survivai has been reported to be as high as 50%. We experienced seven cases of pelvic exepteration for pelvic malignancy between Mar. 1990 and Feb. 1993, Accordingly we present the cases with a brief review of the literatures. Seung Kew Baik, et al..: PeIlvic Exenteration in Treatment of Pelvic Malignancy: 3 Years Experience
Humans ; Pelvic Exenteration* ; Recurrence

BACKGROUND: The reasons for the viral persistence and disease progression of hepatitis B virus (HBV) infection are unknown, but are probably related to host immune factors. Cytokines such as tumor necrosis factor-alpha (TNF-alpha) play significant roles in inflammatory and immune defense. This study was undertaken to investigate the association between HBV infection and polymorphisms of TNF-alpha gene promoter polymorphism. METHODS: We studied 412 Korean patients with chronic HBV infection (72 inactive carriers, 261 chronic hepatitis, 79 liver cirrhosis) and 204 healthy individuals who recovered from HBV infection. We assessed two biallelic polymorphisms in TNF-alpha gene promoter (at position -308, -238) by single base primer extension assay (SNP ITTM). RESULTS: Genotype frequencies of TNF-alpha gene promoter at position -308 and -238 were not different between the clearance and the persistence group in univariate analysis. In multivariate analysis after adjusting age and sex, TNF 308 G/G genotype was associated with HBV persistence (ORs;1.71, p=0.039). Moreover, concerning the haplotype analysis, -308G/ -238G homozygotes showed much higher correlation with HBV persistence (ORs;1.88, p=0.005). Genotype distributions of both gene promoters in inactive carriers were similar to those in patients with chronic progressive liver disease (chronic hepatitis and liver cirrhosis). CONCLUSION: The carriers of -308 G/G genotype and -308G / -238G haplotype homozygotes in the TNF-alpha promoter region have higher risk of persistent HBV infection.
Cytokines ; Disease Progression ; Genotype ; Haplotypes ; Hepatitis ; Hepatitis B virus ; Hepatitis B, Chronic* ; Hepatitis, Chronic* ; Homozygote ; Humans ; Immunologic Factors ; Liver ; Liver Diseases ; Multivariate Analysis ; Promoter Regions, Genetic ; Tumor Necrosis Factor-alpha*

Mannose-binding lectin (MBL) plays an important role in immune defense. This study was undertaken to investigate the association between hepatitis B virus infection and polymorphisms of MBL gene. We assessed the single nucleotide polymorphism at codon 54 in exon 1 of MBL in patients with hepatitis B virus infection and HBsAg negative controls in Korean population. A total of 498 enrolled subjects was classified into four groups. Group 1; Clearance, Group 2; Inactive healthy carrier, Group 3; Chronic hepatitis, Group 4; Liver cirrhosis. MBL gene polymorphisms at codon 54 led to three genotypes (G/G, G/A, A/A). When we divided subjects into clearance group (group 1) and persistence group (group 2-4), G/G genotype and A-allele carrier were observed in 55.6% and 44.4% in clearance group, 64.8% and 35.2% in persistence group (p=0.081), respectively. When hepatitis B virus persistent cases were divided into inactive healthy carrier (group 2) and disease progression group (group 3 and 4), MBL gene polymorphisms at codon 54 were not related to disease progression (p=0.166). MBL gene polymorphism at codon 54 was not associated with the clearance of hepatitis B virus infection nor progression of disease in chronic hepatitis B virus infection.
Adult ; Alleles ; Codon ; Disease Progression ; Female ; Fibrosis ; Genotype ; Hepatitis ; Hepatitis B/*genetics/*metabolism ; Hepatitis B virus/*metabolism ; Heterozygote ; Humans ; Korea ; *Lectins ; Male ; Mannose-Binding Lectin/*chemistry/*genetics ; Middle Aged ; *Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Research Support, Non-U.S. Gov't